Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Laccase-4

Gene

LAC4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Copper 1By similarity1
Metal bindingi88Copper 2By similarity1
Metal bindingi131Copper 2By similarity1
Metal bindingi133Copper 3By similarity1
Metal bindingi480Copper 4By similarity1
Metal bindingi483Copper 1By similarity1
Metal bindingi485Copper 3By similarity1
Metal bindingi542Copper 3By similarity1
Metal bindingi543Copper 4By similarity1
Metal bindingi544Copper 2By similarity1
Metal bindingi548Copper 4By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-4 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 4
Diphenol oxidase 4
Urishiol oxidase 4
Gene namesi
Name:LAC4
Ordered Locus Names:Os01g0842400, LOC_Os01g62480
ORF Names:OsJ_003940, P0406G08.11
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000029188929 – 579Laccase-4Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Glycosylationi403N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi446N-linked (GlcNAc...)Sequence analysis1
Glycosylationi462N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5N9X2.

Expressioni

Gene expression databases

ExpressionAtlasiQ5N9X2. baseline and differential.
GenevisibleiQ5N9X2. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g62480.1.

Structurei

3D structure databases

ProteinModelPortaliQ5N9X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 152Plastocyanin-like 1Add BLAST117
Domaini162 – 316Plastocyanin-like 2Add BLAST155
Domaini429 – 563Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ5N9X2.
KOiK05909.
OMAiAHNITLH.
OrthoDBiEOG093606WG.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5N9X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMAISSALP SPLLLAASLL LLIVQAQGIT RHYEFNVQMA NATRLCNTKS
60 70 80 90 100
MVTVNGQCPG PELVAREGDR VVIRVTNNVA HNISLHWHGV RQVRTGWADG
110 120 130 140 150
PAYITQCPIQ TGQSYVYNFT VAGQRGTLWW HAHISWLRAT VYGALVILPK
160 170 180 190 200
LGVPYPFPAP HKEVPVIFGE WWNADTEEVV NQAVQTGGGP NVSDAFTING
210 220 230 240 250
LPGPLYNCSA QDTFKLKVKP GKTYMLRLIN AALNEELFFA VANHTLTVVE
260 270 280 290 300
VDAVYVKPFT VDTLVISPGQ TTNVLLTAKP YYPGANFYMS AAPYSTARPG
310 320 330 340 350
TFGNTTVAGI LEYENPAMSP SAASFVKGLP LFKPTLPQLN DTDFVTNFTD
360 370 380 390 400
KLRSLATPEY PAAVPQSVDK RFFFTVGLGT LPCPANMTCQ GPNNTQMAAS
410 420 430 440 450
MNNVSFVLPA RALLQSHFTG LSSGVYAPDF PVAPLSPFNY TGTPPNNTNV
460 470 480 490 500
KTGTKLLVLR YNTSVELVMQ DTSILGIESH PLHLHGFNFF VIGQGFGNYD
510 520 530 540 550
AVNDPAKFNL VDPVERNTVG VPAGGWVAIR FLADNPGVWF MHCHLEAHTT
560 570
WGLRMAWLVL DGSHPNQKLL PPPSDLPKC
Length:579
Mass (Da):63,052
Last modified:February 1, 2005 - v1
Checksum:i2480C6A730DC02F3
GO

Sequence cautioni

The sequence EAZ14115 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003240 Genomic DNA. Translation: BAD81734.1.
AP008207 Genomic DNA. Translation: BAF06686.1.
AP014957 Genomic DNA. Translation: BAS75167.1.
CM000138 Genomic DNA. Translation: EAZ14115.1. Different initiation.
AK068901 mRNA. Translation: BAG91149.1.
AF047697 mRNA. Translation: AAC04576.1.
PIRiT02752.
RefSeqiXP_015632622.1. XM_015777136.1.
UniGeneiOs.12346.
Os.81174.

Genome annotation databases

EnsemblPlantsiOS01T0842400-01; OS01T0842400-01; OS01G0842400.
GeneIDi4327500.
GrameneiOS01T0842400-01; OS01T0842400-01; OS01G0842400.
KEGGiosa:4327500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003240 Genomic DNA. Translation: BAD81734.1.
AP008207 Genomic DNA. Translation: BAF06686.1.
AP014957 Genomic DNA. Translation: BAS75167.1.
CM000138 Genomic DNA. Translation: EAZ14115.1. Different initiation.
AK068901 mRNA. Translation: BAG91149.1.
AF047697 mRNA. Translation: AAC04576.1.
PIRiT02752.
RefSeqiXP_015632622.1. XM_015777136.1.
UniGeneiOs.12346.
Os.81174.

3D structure databases

ProteinModelPortaliQ5N9X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os01g62480.1.

Proteomic databases

PaxDbiQ5N9X2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS01T0842400-01; OS01T0842400-01; OS01G0842400.
GeneIDi4327500.
GrameneiOS01T0842400-01; OS01T0842400-01; OS01G0842400.
KEGGiosa:4327500.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ5N9X2.
KOiK05909.
OMAiAHNITLH.
OrthoDBiEOG093606WG.

Gene expression databases

ExpressionAtlasiQ5N9X2. baseline and differential.
GenevisibleiQ5N9X2. OS.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC4_ORYSJ
AccessioniPrimary (citable) accession number: Q5N9X2
Secondary accession number(s): A2ZZG8, B7EFK2, O49232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 1, 2005
Last modified: October 5, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.