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Protein

Laccase-4

Gene

LAC4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Copper 1By similarity1
Metal bindingi88Copper 2By similarity1
Metal bindingi131Copper 2By similarity1
Metal bindingi133Copper 3By similarity1
Metal bindingi480Copper 4By similarity1
Metal bindingi483Copper 1By similarity1
Metal bindingi485Copper 3By similarity1
Metal bindingi542Copper 3By similarity1
Metal bindingi543Copper 4By similarity1
Metal bindingi544Copper 2By similarity1
Metal bindingi548Copper 4By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-4 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 4
Diphenol oxidase 4
Urishiol oxidase 4
Gene namesi
Name:LAC4
Ordered Locus Names:Os01g0842400, LOC_Os01g62480
ORF Names:OsJ_003940, P0406G08.11
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000029188929 – 579Laccase-4Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5N9X2
PRIDEiQ5N9X2

Expressioni

Gene expression databases

ExpressionAtlasiQ5N9X2 differential
GenevisibleiQ5N9X2 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g62480.1

Structurei

3D structure databases

ProteinModelPortaliQ5N9X2
SMRiQ5N9X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 152Plastocyanin-like 1Add BLAST117
Domaini162 – 316Plastocyanin-like 2Add BLAST155
Domaini429 – 563Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ5N9X2
KOiK05909
OMAiFINAASH
OrthoDBiEOG093606WG

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5N9X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMAISSALP SPLLLAASLL LLIVQAQGIT RHYEFNVQMA NATRLCNTKS
60 70 80 90 100
MVTVNGQCPG PELVAREGDR VVIRVTNNVA HNISLHWHGV RQVRTGWADG
110 120 130 140 150
PAYITQCPIQ TGQSYVYNFT VAGQRGTLWW HAHISWLRAT VYGALVILPK
160 170 180 190 200
LGVPYPFPAP HKEVPVIFGE WWNADTEEVV NQAVQTGGGP NVSDAFTING
210 220 230 240 250
LPGPLYNCSA QDTFKLKVKP GKTYMLRLIN AALNEELFFA VANHTLTVVE
260 270 280 290 300
VDAVYVKPFT VDTLVISPGQ TTNVLLTAKP YYPGANFYMS AAPYSTARPG
310 320 330 340 350
TFGNTTVAGI LEYENPAMSP SAASFVKGLP LFKPTLPQLN DTDFVTNFTD
360 370 380 390 400
KLRSLATPEY PAAVPQSVDK RFFFTVGLGT LPCPANMTCQ GPNNTQMAAS
410 420 430 440 450
MNNVSFVLPA RALLQSHFTG LSSGVYAPDF PVAPLSPFNY TGTPPNNTNV
460 470 480 490 500
KTGTKLLVLR YNTSVELVMQ DTSILGIESH PLHLHGFNFF VIGQGFGNYD
510 520 530 540 550
AVNDPAKFNL VDPVERNTVG VPAGGWVAIR FLADNPGVWF MHCHLEAHTT
560 570
WGLRMAWLVL DGSHPNQKLL PPPSDLPKC
Length:579
Mass (Da):63,052
Last modified:February 1, 2005 - v1
Checksum:i2480C6A730DC02F3
GO

Sequence cautioni

The sequence EAZ14115 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003240 Genomic DNA Translation: BAD81734.1
AP008207 Genomic DNA Translation: BAF06686.1
AP014957 Genomic DNA Translation: BAS75167.1
CM000138 Genomic DNA Translation: EAZ14115.1 Different initiation.
AK068901 mRNA Translation: BAG91149.1
AF047697 mRNA Translation: AAC04576.1
PIRiT02752
RefSeqiXP_015632622.1, XM_015777136.1
UniGeneiOs.12346
Os.81174

Genome annotation databases

EnsemblPlantsiOs01t0842400-01; Os01t0842400-01; Os01g0842400
GeneIDi4327500
GrameneiOs01t0842400-01; Os01t0842400-01; Os01g0842400
KEGGiosa:4327500

Similar proteinsi

Entry informationi

Entry nameiLAC4_ORYSJ
AccessioniPrimary (citable) accession number: Q5N9X2
Secondary accession number(s): A2ZZG8, B7EFK2, O49232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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