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Q5N9X2

- LAC4_ORYSJ

UniProt

Q5N9X2 - LAC4_ORYSJ

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Protein

Laccase-4

Gene

LAC4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Copper 1By similarity
Metal bindingi88 – 881Copper 2By similarity
Metal bindingi131 – 1311Copper 2By similarity
Metal bindingi133 – 1331Copper 3By similarity
Metal bindingi480 – 4801Copper 4By similarity
Metal bindingi483 – 4831Copper 1By similarity
Metal bindingi485 – 4851Copper 3By similarity
Metal bindingi542 – 5421Copper 3By similarity
Metal bindingi543 – 5431Copper 4By similarity
Metal bindingi544 – 5441Copper 2By similarity
Metal bindingi548 – 5481Copper 4By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-4 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 4
Diphenol oxidase 4
Urishiol oxidase 4
Gene namesi
Name:LAC4
Ordered Locus Names:Os01g0842400, LOC_Os01g62480
ORF Names:OsJ_003940, P0406G08.11
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ5N9X2.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 579551Laccase-4PRO_0000291889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

ExpressionAtlasiQ5N9X2. baseline.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g62480.1.

Structurei

3D structure databases

ProteinModelPortaliQ5N9X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 152117Plastocyanin-like 1Add
BLAST
Domaini162 – 316155Plastocyanin-like 2Add
BLAST
Domaini429 – 563135Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ5N9X2.
OMAiCASKSIV.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5N9X2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMAISSALP SPLLLAASLL LLIVQAQGIT RHYEFNVQMA NATRLCNTKS
60 70 80 90 100
MVTVNGQCPG PELVAREGDR VVIRVTNNVA HNISLHWHGV RQVRTGWADG
110 120 130 140 150
PAYITQCPIQ TGQSYVYNFT VAGQRGTLWW HAHISWLRAT VYGALVILPK
160 170 180 190 200
LGVPYPFPAP HKEVPVIFGE WWNADTEEVV NQAVQTGGGP NVSDAFTING
210 220 230 240 250
LPGPLYNCSA QDTFKLKVKP GKTYMLRLIN AALNEELFFA VANHTLTVVE
260 270 280 290 300
VDAVYVKPFT VDTLVISPGQ TTNVLLTAKP YYPGANFYMS AAPYSTARPG
310 320 330 340 350
TFGNTTVAGI LEYENPAMSP SAASFVKGLP LFKPTLPQLN DTDFVTNFTD
360 370 380 390 400
KLRSLATPEY PAAVPQSVDK RFFFTVGLGT LPCPANMTCQ GPNNTQMAAS
410 420 430 440 450
MNNVSFVLPA RALLQSHFTG LSSGVYAPDF PVAPLSPFNY TGTPPNNTNV
460 470 480 490 500
KTGTKLLVLR YNTSVELVMQ DTSILGIESH PLHLHGFNFF VIGQGFGNYD
510 520 530 540 550
AVNDPAKFNL VDPVERNTVG VPAGGWVAIR FLADNPGVWF MHCHLEAHTT
560 570
WGLRMAWLVL DGSHPNQKLL PPPSDLPKC
Length:579
Mass (Da):63,052
Last modified:February 1, 2005 - v1
Checksum:i2480C6A730DC02F3
GO

Sequence cautioni

The sequence EAZ14115.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003240 Genomic DNA. Translation: BAD81734.1.
AP008207 Genomic DNA. Translation: BAF06686.1.
CM000138 Genomic DNA. Translation: EAZ14115.1. Different initiation.
AK068901 mRNA. No translation available.
AF047697 mRNA. Translation: AAC04576.1.
PIRiT02752.
RefSeqiNP_001044772.1. NM_001051307.1.
UniGeneiOs.12346.

Genome annotation databases

EnsemblPlantsiOS01T0842400-01; OS01T0842400-01; OS01G0842400.
GeneIDi4327500.
KEGGiosa:4327500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003240 Genomic DNA. Translation: BAD81734.1 .
AP008207 Genomic DNA. Translation: BAF06686.1 .
CM000138 Genomic DNA. Translation: EAZ14115.1 . Different initiation.
AK068901 mRNA. No translation available.
AF047697 mRNA. Translation: AAC04576.1 .
PIRi T02752.
RefSeqi NP_001044772.1. NM_001051307.1.
UniGenei Os.12346.

3D structure databases

ProteinModelPortali Q5N9X2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os01g62480.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0842400-01 ; OS01T0842400-01 ; OS01G0842400 .
GeneIDi 4327500.
KEGGi osa:4327500.

Organism-specific databases

Gramenei Q5N9X2.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q5N9X2.
OMAi CASKSIV.

Gene expression databases

ExpressionAtlasi Q5N9X2. baseline.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  6. "Characterization and heterologous expression of laccase cDNAs from xylem tissues of yellow-poplar (Liriodendron tulipifera)."
    LaFayette P.R., Eriksson K.E., Dean J.F.
    Plant Mol. Biol. 40:23-35(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-579.
    Strain: cv. Nipponbare.
    Tissue: Shoot.

Entry informationi

Entry nameiLAC4_ORYSJ
AccessioniPrimary (citable) accession number: Q5N9X2
Secondary accession number(s): A2ZZG8, O49232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3