Q5N643 (SYR_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	syc0034_c

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	584 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 584	584	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000242108
Regions
	Motif	126 – 136	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q5N643 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: A8591A4497FC4999	FASTA	584	65,082
	10 20 30 40 50 60 MAAPLAQLRD RFQAALAASF GPEWAATDPL LVPATNPKFG DYQSNVAMSL AKQLGQPPRA 70 80 90 100 110 120 IAETLVQNLN LADLCEPPAI AGPGFINFTL QPSYLVAQLQ QLQTDERLGI QPVSPPQRVI 130 140 150 160 170 180 VDFSSPNIAK EMHVGHLRST IIGDSIARVL EFQGHEVLRL NHVGDWGTQF GMLIAFLQEQ 190 200 210 220 230 240 YPQALSQPDA LDISDLVAFY KQAKARFDED PSFQETARQR VVDLQSGEAT ARQAWQLLCD 250 260 270 280 290 300 QSRREFQKIY DRLDIQLEER GESFYNPYLP AIVEDLRRLG LLVEDQGAQC VFLEGFQNKE 310 320 330 340 350 360 GQPLPLIVQK SDGGYNYATT DLAALRYRLG QDQAQRIIYV TDSGQANHFA QVFQVAQRAG 370 380 390 400 410 420 WLPAAAQIEH VPFGLVQGED GKKLKTRAGD TVRLRDLLDE AVDRARTDLT TRIAAEERSE 430 440 450 460 470 480 TPEFIEAVAQ AVGLGAVKYA DLSQNRNSNY IFSFDKMLAL QGNTAPYLLY AYVRIQGIAR 490 500 510 520 530 540 KGGIDFAQLD PVAAELTEPT ERSLAKQVLQ LGEVLDEVAR DLLPNRLCSY LFELSQTFNQ 550 560 570 580 FYDRCPILNA EEPQRTSRLL LCDLTARTLK LGLSLLGISV LERM

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD78224.1.
RefSeq	YP_170744.1. NC_006576.1.
3D structure databases
ProteinModelPortal	Q5N643.
ModBase	Search...
Protein-protein interaction databases
STRING	269084.syc0034_c.
Proteomic databases
PRIDE	Q5N643.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD78224; BAD78224; syc0034_c.
GeneID	3198294.
KEGG	syc:syc0034_c.
PATRIC	32485532. VBISynElo117686_0046.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247212.
KO	K01887.
OMA	QGAKCVF.
ProtClustDB	PRK01611.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_SYNP6

Accession

Primary (citable) accession number: Q5N643

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program