Q5N5V5 (ARGC_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	syc0123_c

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112464
Sites
	Active site	155	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5N5V5 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: A5003433C7EE9545	FASTA	352	38,119
	10 20 30 40 50 60 MHESSRLPVG IIGASGYGGV QLVRLLQDHP QLEVAYLGGD RSAGKEFAEL YPHLGPHLNL 70 80 90 100 110 120 TIEAIDVDRI AERCAAVFLS LPNGLAYDLA PALLERGCKV LDLSADYRFH DLKTYALWYG 130 140 150 160 170 180 GDRQDAAVAH TAIYGLPELY RNRIANAQLI GCPGCYPTAS LLALAPALKQ GLIDPDTIVI 190 200 210 220 230 240 DAKSGTSGAG RQAKTNALLA EAGNSVGAYG VARHRHTPEI EQICSDLSGH EVLLQFTPHL 250 260 270 280 290 300 MPMVRGIHAT IYAKLRDPNL TTEDCLTVYQ AFYRNAPMVK VLTHGTYPQT KWAAGTNLCY 310 320 330 340 350 LGLEVDARTG RIVLLSAIDN LIKGQAGQAI QCLNLMQGWE EGLGLPTLCY YP

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed: 17211581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD78313.1.
RefSeq	YP_170833.1. NC_006576.1.
3D structure databases
ProteinModelPortal	Q5N5V5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5N5V5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3198401.
GenomeReviews	Gene locus syc0123_c in contig AP008231_GR.
KEGG	syc:syc0123_c.
PATRIC	32485739. VBISynElo117686_0148.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	Q5N5V5.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	SELO269084:SYC0123_C-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_SYNP6

Accession

Primary (citable) accession number: Q5N5V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program