Q5N530 (PANCY_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

1. Pantoate--beta-alanine ligase
   EC=6.3.2.1
   Alternative name(s):
   Pantoate-activating enzyme
   Pantothenate synthetase
2. Cytidylate kinase
   Short name=CK
   EC=2.7.4.14
   Alternative name(s):
   Cytidine monophosphate kinase
   Short name=CMP kinase

Gene names

Name:	panC/cmk
Ordered Locus Names:	syc0399_d

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_01349 ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_01349
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_01349
Subcellular location	Cytoplasm By similarity.
Sequence similarities	In the N-terminal section; belongs to the pantothenate synthetase family. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Ligase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: EC pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 527	527	Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_01349		PRO_0000239797
Regions
	Nucleotide binding	290 – 298	9	ATP By similarity
	Region	1 – 277	277	Pantoate--beta-alanine ligase HAMAP-Rule MF_01349
	Region	278 – 527	250	Cytidylate kinase HAMAP-Rule MF_01349

Sequences

	Sequence		Length	Mass (Da)
	Q5N530 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 1D7DAFE30F0944E0	FASTA	527	57,098
	10 20 30 40 50 60 MRQLISPEAL RAFRQSVQGS VGFVPTMGAL HAGHRSLIER SRQQDDVVIV SIFVNPRQFG 70 80 90 100 110 120 PQEDLSRYPQ TLDADLALCE AAGVDAVFCP TAEALYPRPS DRSTGVQPPA ELIQSLCGRQ 130 140 150 160 170 180 RPGHFQGVAT VVLKLLQLVQ PQRAYFGEKD AQQLRVIQRL VEDFNLPIAI VPCPTVREPD 190 200 210 220 230 240 GLALSSRNRY LTFEERSQAS GLYRALRAAA ECFQAGSRDS QELVAAATAV LATTPAVQLE 250 260 270 280 290 300 YCDCVDADSL QPLTQIPDRA LLAIAARVGT ARLIDNLTLQ GRRPIIAIDG PAGAGKSTVT 310 320 330 340 350 360 KRLAQQLGLL YLDTGAMYRA VTWLVQQQGI DPQDPIVLAE LLAQADLQLR SQPAADGSEQ 370 380 390 400 410 420 LQVLIQGNDV TAAIRTPTVT AQVSAIAALP LVRQFLVEQQ RQLGQRGGLV AEGRDIGTHV 430 440 450 460 470 480 FPDAELKIFL TATNAERARR RALDLEAQGL TVDLAQLEAE IRDRDRQDSE RAIAPLCKAE 490 500 510 520 DAVEVLTDGL SIEAVTDQII RLYRDRGLGD SSPQATPGQT PSPLSLG

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD78589.1.
RefSeq	YP_171109.1. NC_006576.1.
3D structure databases
ProteinModelPortal	Q5N530.
ModBase	Search...
Protein-protein interaction databases
STRING	269084.syc0399_d.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD78589; BAD78589; syc0399_d.
GeneID	3199935.
KEGG	syc:syc0399_d.
PATRIC	32486368. VBISynElo117686_0460.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
HOGENOM	HOG000233355.
KO	K13799.
OMA	LGEKDWQ.
ProtClustDB	PRK13477.
Enzyme and pathway databases
UniPathway	UPA00028; UER00005.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_01349. PanCY.
InterPro	IPR004821. Cyt_trans-like. IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. IPR003721. Pantoate_ligase. IPR024894. Pantoate_ligase/cytidylate_kin. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit. TIGR00125. cyt_tran_rel. 1 hit. TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANCY_SYNP6

Accession

Primary (citable) accession number: Q5N530

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program