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Q5N530

- PANCY_SYNP6

UniProt

Q5N530 - PANCY_SYNP6

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
    ATP + (d)CMP = ADP + (d)CDP.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi290 – 2989ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSELO269084:GCDQ-406-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinase
    Including the following 2 domains:
    Pantoate--beta-alanine ligase (EC:6.3.2.1)
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
    Cytidylate kinase (EC:2.7.4.14)
    Short name:
    CK
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name:
    CMP kinase
    Gene namesi
    Name:panC/cmk
    Ordered Locus Names:syc0399_d
    OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
    Taxonomic identifieri269084 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001175: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Bifunctional pantoate ligase/cytidylate kinasePRO_0000239797Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269084.syc0399_d.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5N530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 277277Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni278 – 527250Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.Curated
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5N530-1 [UniParc]FASTAAdd to Basket

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    MRQLISPEAL RAFRQSVQGS VGFVPTMGAL HAGHRSLIER SRQQDDVVIV    50
    SIFVNPRQFG PQEDLSRYPQ TLDADLALCE AAGVDAVFCP TAEALYPRPS 100
    DRSTGVQPPA ELIQSLCGRQ RPGHFQGVAT VVLKLLQLVQ PQRAYFGEKD 150
    AQQLRVIQRL VEDFNLPIAI VPCPTVREPD GLALSSRNRY LTFEERSQAS 200
    GLYRALRAAA ECFQAGSRDS QELVAAATAV LATTPAVQLE YCDCVDADSL 250
    QPLTQIPDRA LLAIAARVGT ARLIDNLTLQ GRRPIIAIDG PAGAGKSTVT 300
    KRLAQQLGLL YLDTGAMYRA VTWLVQQQGI DPQDPIVLAE LLAQADLQLR 350
    SQPAADGSEQ LQVLIQGNDV TAAIRTPTVT AQVSAIAALP LVRQFLVEQQ 400
    RQLGQRGGLV AEGRDIGTHV FPDAELKIFL TATNAERARR RALDLEAQGL 450
    TVDLAQLEAE IRDRDRQDSE RAIAPLCKAE DAVEVLTDGL SIEAVTDQII 500
    RLYRDRGLGD SSPQATPGQT PSPLSLG 527
    Length:527
    Mass (Da):57,098
    Last modified:February 1, 2005 - v1
    Checksum:i1D7DAFE30F0944E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD78589.1.
    RefSeqiWP_011242711.1. NC_006576.1.
    YP_171109.1. NC_006576.1.

    Genome annotation databases

    EnsemblBacteriaiBAD78589; BAD78589; syc0399_d.
    GeneIDi3199935.
    KEGGisyc:syc0399_d.
    PATRICi32486368. VBISynElo117686_0460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD78589.1 .
    RefSeqi WP_011242711.1. NC_006576.1.
    YP_171109.1. NC_006576.1.

    3D structure databases

    ProteinModelPortali Q5N530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269084.syc0399_d.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD78589 ; BAD78589 ; syc0399_d .
    GeneIDi 3199935.
    KEGGi syc:syc0399_d.
    PATRICi 32486368. VBISynElo117686_0460.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci SELO269084:GCDQ-406-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
      Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
      Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

    Entry informationi

    Entry nameiPANCY_SYNP6
    AccessioniPrimary (citable) accession number: Q5N530
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3