Q5N4Z6 (PGK_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	syc0433_c

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Phosphoglycerate kinase HAMAP-Rule MF_00145		PRO_1000058077
Regions
	Nucleotide binding	357 – 360	4	ATP By similarity
	Region	24 – 26	3	Substrate binding By similarity
	Region	63 – 66	4	Substrate binding By similarity
Sites
	Binding site	40	1	Substrate By similarity
	Binding site	122	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	206	1	ATP By similarity
	Binding site	297	1	ATP; via carbonyl oxygen By similarity
	Binding site	328	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5N4Z6 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 704A8D7B83E45CF6	FASTA	402	41,961
	10 20 30 40 50 60 MSKRTLASLT AADLEGKRVL VRVDFNVPLD GNGKITDDTR IRAALPTIRY LSESGAKVIL 70 80 90 100 110 120 VSHFGRPKGK PVESMRLTPV AERLSELLGR PVVKTTDAVG AGAEAQVAAT SNGQVVLLEN 130 140 150 160 170 180 VRFHAEEEAN DAEFAKALAS LADIYVNDAF GAAHRAHAPT AGVTEYLSPC VAGYLLEKEL 190 200 210 220 230 240 QYLQAAIDNP QRPLAAIVGG SKVSSKIGVI ETLLDKCDKL LIGGGMIFTF YKAQGLSVGG 250 260 270 280 290 300 SLVEEDKLDL ARSLMAKAQE KGVQLLLPVD VVVADKFAPD ANAKTVAIDA IPDGWMGLDI 310 320 330 340 350 360 GPESVKQFEG ALADCRSVIW NGPMGVFEFD QFAVGTEAIA RSLAGLTRKG ATTIIGGGDS 370 380 390 400 VAAVEKVGVA SEMSHISTGG GASLELLEGK VLPGVAALDD AA

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD78623.1.
RefSeq	YP_171143.1. NC_006576.1.
3D structure databases
HSSP	HSSP built from PDB template 1PHP based on UniProtKB P18912.
ProteinModelPortal	Q5N4Z6.
SMR	Q5N4Z6. Positions 1-400.
ModBase	Search...
Protein-protein interaction databases
STRING	269084.syc0433_c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD78623; BAD78623; syc0433_c.
GeneID	3200035.
KEGG	syc:syc0433_c.
PATRIC	32486446. VBISynElo117686_0497.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227107.
KO	K00927.
OMA	KFGLADK.
ProtClustDB	PRK00073.
Enzyme and pathway databases
UniPathway	UPA00109; UER00185.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
HAMAP	MF_00145. Phosphoglyc_kinase.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_SYNP6

Accession

Primary (citable) accession number: Q5N4Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program