Q5N2M1 (Q5N2M1_SYNP6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL BAD79449.1
Ordered Locus Names:	syc1259_c

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	856 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5N2M1 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 717F46A2D0E00697	FASTA	856	95,270
	10 20 30 40 50 60 MSAQERIIQT DLRNEMSRSY LEYAMSVIVG RALPDARDGL KPVHRRILYA MYELGLTPDR 70 80 90 100 110 120 PFRKCARVVG EVLGKYHPHG DTAVYDALVR MAQDFSMRSP LIDGHGNFGS IDNDPPAAMR 130 140 150 160 170 180 YTESRLKPLT TDGLLQDIEA ETVDFSDNFD GSQQEPTVLP ARLPQLLLNG SSGIAVGMAT 190 200 210 220 230 240 NIPPHNPTEL IAGVIALIHN PEISDRELMR HIPGPDFPTG GQVLGSAGIR DAYLTGKGSI 250 260 270 280 290 300 TMRGVATIDT IEAPGRPVRD AIIITELPYQ TNKAALIERI AEMVNEKRLE GISDIRDESD 310 320 330 340 350 360 RDGMRIVIEL KRDAYPQVVL NNLYKQTPLQ SNFSANMLAL VDGEPVLLTL KRSLEVFLDF 370 380 390 400 410 420 RIETIERRTR YELRKAEERD HLLQGLLIAL GNLDAIIELI RRSADAPRAK QELIDVYGLS 430 440 450 460 470 480 EVQSDAILQM QLRRLTALEA EKIEQEHQDL QRRIEDYRDI LARRERVLEI IETELEQLQQ 490 500 510 520 530 540 RFQEPRRTTL LEADGELETI DLIANEKSIL LLTQQGYIKR MPVNEFTAQS RGTRGKAGAK 550 560 570 580 590 600 TKDDDSVEHF LTCCDHDNIL FFSDRGVVYN LPAYRIPAAS RNARGVPIVQ LLPIPREERI 610 620 630 640 650 660 TSIVPVSAFS DDEYLVMLTQ GGYIKKTALS AFANIRSNGL IAIALSEGDQ LRWVRLAKPE 670 680 690 700 710 720 DSILIGSRKG MTIHFRASHD DLRPLGRATR GVRAMSLRSG DTLISMDVLP ASLTANMTET 730 740 750 760 770 780 GDEDEADDAV EVVASPGPWV LVVTAQGLGK RVPVHQFRLQ KRAGLGLRAI KFRSKQDELV 790 800 810 820 830 840 SLRIVESGDE LVMISQRSVI IRQASDAIPQ QSRAATGVRV QRLDADDVLA AVALVPPGEE 850 ELDETSEDAI ASDEPN

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed: 17211581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD79449.1.
RefSeq	YP_171969.1. NC_006576.1.
3D structure databases
ProteinModelPortal	Q5N2M1.
SMR	Q5N2M1. Positions 29-490.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5N2M1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3200150.
GenomeReviews	Gene locus syc1259_c in contig AP008231_GR.
KEGG	syc:syc1259_c.
PATRIC	32488393. VBISynElo117686_1454.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TSIPPHR.
PhylomeDB	Q5N2M1.
ProtClustDB	PRK05560.
Enzyme and pathway databases
BioCyc	SELO269084:SYC1259_C-MONOMER.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5N2M1_SYNP6

Accession

Primary (citable) accession number: Q5N2M1

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)