Q5N2J9 (AROA_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	syc1281_d

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325383

Sequences

	Sequence		Length	Mass (Da)
	Q5N2J9 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: F45D7771FF42EAAE	FASTA	448	47,454
	10 20 30 40 50 60 MAQPFVLLPT EDSHQTLRIQ PPSTGIGLRG RIRVPGDKSI SHRALMLGAI ASGETTIEGL 70 80 90 100 110 120 LLGEDPLSTA ACFRAMGAEI SELNSELVRV KGIGLQNLQE PLDVLNAGNS GTTIRLMMGL 130 140 150 160 170 180 LAGQRDRFFC VTGDESLRSR PMARVIQPLS QMGAEIRGRQ GNTRAPLAIS GRSLQPIRYV 190 200 210 220 230 240 SPIASAQVKS SILLAGLTCE GQTTVVEPAL SRDHSERMFR AFGAKLTVNP EEISVTVEGP 250 260 270 280 290 300 AELTGQPVVV PGDISSAAFW LVAAAIVPDS DLLIENVGVN PTRTGILEAL QQMEAQITLE 310 320 330 340 350 360 NERIVAGEPV ADLRVRSSNL QAIEIGGSLI PRLIDEVPIL AVAAAFAKGT TIIRDAEELR 370 380 390 400 410 420 VKESDRIAVM ASELGRMGAT ISERPDGLEI TGGAALTGAT VDSYTDHRIA MSLAIAALQA 430 440 KGQTQIQQAE AAAVSYPDFV PTLQQLLG

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed: 17211581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD79471.1.
RefSeq	YP_171991.1. NC_006576.1.
3D structure databases
HSSP	HSSP built from PDB template 1RF6 based on UniProtKB Q9S400.
ProteinModelPortal	Q5N2J9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5N2J9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3197810.
GenomeReviews	Gene locus syc1281_d in contig AP008231_GR.
KEGG	syc:syc1281_d.
PATRIC	32488437. VBISynElo117686_1476.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GEDPRST.
PhylomeDB	Q5N2J9.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	SELO269084:SYC1281_D-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_SYNP6

Accession

Primary (citable) accession number: Q5N2J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program