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Q5N2B2 (HEMH_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:syc1368_c
OrganismSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]
Taxonomic identifier269084 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Ferrochelatase HAMAP MF_00323
PRO_0000175216

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5N2B2 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: DBE58C11AE0DE78B

FASTA38744,294
        10         20         30         40         50         60 
MGRVGVLLLN LGGPERLEDV GPFLYNLFAD PEIIRLPFPW LQKPLAWLIS SLRTRKSQEN 

        70         80         90        100        110        120 
YKQIGGGSPL RRITEEQATA LRQSLSDRGQ AAQVYIGMRY WHPFTEEAIA QIKADGIDRL 

       130        140        150        160        170        180 
VILPLYPQFS ISTSGSSFRL LQRLRDRDPE FQKIDCSVVP SWYERSGYLQ AMAELIAQEL 

       190        200        210        220        230        240 
DKLEQPEQGH VFFSAHGVPV SYVEEAGDPY QREIEDCTRK IMETLGRSNP WTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLQPYTE DALEELAERG VKDLVVVPIS FVSEHIETLE EIDIEYREIA EEAGIERFLR 

       310        320        330        340        350        360 
VPALNTHPLF IQDLSDLVEQ TLEQPRFRLE DVTLLPKKVK LYPQERWEWG ITLNAEVWNG 

       370        380 
RIAMLGFLAL LVELLTGRGP LHALGLL

« Hide

References

[1]"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
Photosyn. Res. 93:55-67(2007) [PubMed: 17211581] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008231 Genomic DNA. Translation: BAD79558.1.
RefSeqYP_172078.1. NC_006576.1.

3D structure databases

ProteinModelPortalQ5N2B2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5N2B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3199419.
GenomeReviewsGene locus syc1368_c in contig AP008231_GR.
KEGGsyc:syc1368_c.
PATRIC32488649. VBISynElo117686_1580.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBQ5N2B2.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycSELO269084:SYC1368_C-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
Gene3DG3DSA:1.10.3460.10. G3DSA:1.10.3460.10. 1 hit.
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
SUPFAMSSF103511. SSF103511. 1 hit.
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SYNP6
AccessionPrimary (citable) accession number: Q5N2B2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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