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Protein

NAD kinase 1

Gene

nadK1

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78Proton acceptorUniRule annotation1
Binding sitei182NADUniRule annotation1
Binding sitei251NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 79NADUniRule annotation2
Nucleotide bindingi152 – 153NADUniRule annotation2
Nucleotide bindingi193 – 198NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSELO269084:G1G2F-1940-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 1UniRule annotation
Gene namesi
Name:nadK1UniRule annotation
Ordered Locus Names:syc1797_c
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001175 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297011 – 305NAD kinase 1Add BLAST305

Proteomic databases

PRIDEiQ5N133

Interactioni

Protein-protein interaction databases

STRINGi269084.syc1797_c

Structurei

3D structure databases

ProteinModelPortaliQ5N133
SMRiQ5N133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q5N133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVGIIYND SKPRACTIAE ELQQQLQDRG WGVRLATSQS GLLGYSNPDT
60 70 80 90 100
VICHTPVESL VPRGFDASLR WAIVLGGDGT VLAAARQLAP IGVPMLTVNT
110 120 130 140 150
GHLGFLAEAY LDSLPAAIEQ LCKGEYSIEE RTMMEVKVLR RELIRWEALS
160 170 180 190 200
LNEMALHREP LTSMCHFEVA IGKHVPVDIA ADGVIVSTPT GSTAYSLSSG
210 220 230 240 250
GPVVTPDVPV FQLVPICPHS LASRALVFAN REPMTIFPAT PERLMMVVDG
260 270 280 290 300
NAGCYVWPED RVLIQRSRYP AQFIRLQPNE FFRVLREKLG WGLPHVAKPS

APDQS
Length:305
Mass (Da):33,422
Last modified:February 1, 2005 - v1
Checksum:i2CA654EED5412A6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008231 Genomic DNA Translation: BAD79987.1
RefSeqiWP_011244107.1, NC_006576.1

Genome annotation databases

EnsemblBacteriaiBAD79987; BAD79987; syc1797_c
KEGGisyc:syc1797_c

Similar proteinsi

Entry informationi

Entry nameiNADK1_SYNP6
AccessioniPrimary (citable) accession number: Q5N133
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health