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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei322Proton donorUniRule annotation1
Active sitei351UniRule annotation1
Active sitei455UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:syc2066_c
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001175 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807531 – 528Glucose-6-phosphate isomeraseAdd BLAST528

Interactioni

Protein-protein interaction databases

STRINGi269084.syc2066_c.

Structurei

3D structure databases

ProteinModelPortaliQ5N0B4.
SMRiQ5N0B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166. LUCA.
HOGENOMiHOG000131425.
KOiK01810.
OMAiTNSQHAF.
OrthoDBiPOG091H04C3.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 2 hits.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5N0B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQQLWQRY LDWLYYDPSL EFYLDISRMG FDDAFVTSMQ PKFQHAFAAM
60 70 80 90 100
AELEAGAIAN PDEQRMVGHY WLRDPELAPT PELQTQIRDT LAAIQDFALK
110 120 130 140 150
VHSGVLRPPT GSRFTDILSI GIGGSALGPQ FVSEALRPQA ALLQIHFFDN
160 170 180 190 200
TDPAGFDRVL ADLGDRLAST LVIVISKSGG TPETRNGMLE VQSAFAQRGI
210 220 230 240 250
AFAPQAVAVT GVGSHLDHVA ITERWLARFP MEDWVGGRTS ELSAVGLLSA
260 270 280 290 300
ALLGIDITAM LAGARQMDAL TRHSDLRQNP AALLALSWYW AGNGQGKKDM
310 320 330 340 350
VILPYKDSLL LFSRYLQQLI MESLGKERDL LGKVVHQGIA VYGNKGSTDQ
360 370 380 390 400
HAYVQQLREG IPNFFATFIE VLEDRQGPSP VVEPGITSGD YLSGLLQGTR
410 420 430 440 450
AALYENGRES ITITVPRVDA QQVGALIALY ERAVGLYASL VGINAYHQPG
460 470 480 490 500
VEAGKKAAAG VLEIQRQIVE LLQQGQPLSI AAIADDLGQS EQIETIYKIL
510 520
RHLEANQRGV QLTGDRHNPL SLIASWQR
Length:528
Mass (Da):57,795
Last modified:February 1, 2005 - v1
Checksum:iDDBA0B6484B358FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008231 Genomic DNA. Translation: BAD80256.1.
RefSeqiWP_011244376.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80256; BAD80256; syc2066_c.
KEGGisyc:syc2066_c.

Similar proteinsi

Entry informationi

Entry nameiG6PI_SYNP6
AccessioniPrimary (citable) accession number: Q5N0B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 1, 2005
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families