Q5N075 (MSCL_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	syc2105_d

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000238045
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	73 – 93	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5N075 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 81CBBE48E06394DB	FASTA	133	14,398
	10 20 30 40 50 60 MTSRRGRAVG FIRDFQAFIL KGNVVELAVA VIIGGAFNKI VSSFVGDLVM PLVNPLIPGG 70 80 90 100 110 120 DWRTAVIGPG LKIGSFAGSV IDFLIIAFVL YLAIRAIERF KRKEEAVVAA AEPDVQQQML 130 ATLERIADNL EAR

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed: 17211581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD80295.1.
RefSeq	YP_172815.1. NC_006576.1.
3D structure databases
ProteinModelPortal	Q5N075.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5N075.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3199224.
GenomeReviews	Gene locus syc2105_d in contig AP008231_GR.
KEGG	syc:syc2105_d.
PATRIC	32490331. VBISynElo117686_2397.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
HOGENOM	HBG727604.
OMA	ANVKNIA.
PhylomeDB	Q5N075.
ProtClustDB	CLSK743920.
Enzyme and pathway databases
BioCyc	SELO269084:SYC2105_D-MONOMER.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_SYNP6

Accession

Primary (citable) accession number: Q5N075

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program