Q5N052 (UPPP_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	cacA
Ordered Locus Names:	syc2128_c

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151224
Regions
	Transmembrane	58 – 78	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Transmembrane	208 – 228	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential
	Transmembrane	274 – 294	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5N052 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 8AF962E46C642EF6	FASTA	297	31,811
	10 20 30 40 50 60 MTNGQEPIAM LIAVSSADRL DLWQAIVLGF VQGATEFLPI SSTAHLKVVP VVLGWGDPGV 70 80 90 100 110 120 AFTAVIQLGS IVAVLSYFRQ DLTYVLRGLV SAVRRQDFRS EPAQMGLGIL FGTIPILIGG 130 140 150 160 170 180 LLIKRFIPDY DNSPLRSLAA IAIVSIVMGL LLGIAEQLSK HQRDLSQLRL ADGLWMGFAQ 190 200 210 220 230 240 ALALIPGVSR SGSTLTAGLF QGLKRDTAAR FSFLLGIPAI TIAGLVELKD LLEAGIDGSS 250 260 270 280 290 LGVLAIGTLS SLIFSWLAIA WLLRFLRTHN TWSFVVYRII FGGVILTAIA TGTLQNI

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD80318.1.
RefSeq	YP_172838.1. NC_006576.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	269084.syc2128_c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD80318; BAD80318; syc2128_c.
GeneID	3199301.
KEGG	syc:syc2128_c.
PATRIC	32490389. VBISynElo117686_2426.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	WFIIVAT.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_SYNP6

Accession

Primary (citable) accession number: Q5N052

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program