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Q5N006

- SYL_SYNP6

UniProt

Q5N006 - SYL_SYNP6

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei632 – 6321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSELO269084:GCDQ-2230-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:syc2174_d
    OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
    Taxonomic identifieri269084 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001175: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 865865Leucine--tRNA ligasePRO_0000152103Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269084.syc2174_d.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5N006.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi58 – 6811"HIGH" regionAdd
    BLAST
    Motifi629 – 6335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5N006-1 [UniParc]FASTAAdd to Basket

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    MQNGANSRSQ EYQGVSVDSR YDPQAIETKW QQSWAAAQLD RTPEADDRPK    50
    FYALSMFPYP SGNLHMGHVR NYTITDAIAR VKRRQGFRVL HAMGWDAFGL 100
    PAENAAIDRG VQPADWTYQN VAQMREQLKQ LGLSYDWDRE VTTCSPDYYR 150
    WTQWLFLQFF EAGLAYQKEA TVNWDPIDQT VLANEQVDSE GRSWRSGAKV 200
    ERRQLKQWFL KITDYAEELL QDLDQLTGWP ERVRLMQANW IGKSTGAYLE 250
    FPIVNSSDRV KVFTTRPDTV YGVSYVVLAP EHPLVTQVTT PEQQTAVAAF 300
    AAEVSQTSEL ERTAEDRPKR GVPTGGFVTN PFTGQAVPIW IADYVLVEYG 350
    TGAVMGVPAH DSRDFAFAQR YGLPVQPVIQ PTEGAIAEPW PAPFTEAGVM 400
    VNSGQFDGLS STEAKAKIIA FAEEQGWGQA HVQYRLRDWL ISRQRYWGCP 450
    IPIVHCPDCG PVAAADLPVQ LPDSVQFSGR GPSPLAQLED WVTTTCPSCG 500
    KPARRETDTM DTFMCSSWYY LRYSDASNPE IAFTKDKVND WLPVDQYVGG 550
    IEHAILHLLY SRFFTKVLRD RGLLSFDEPF KRLLTQGMVQ GLTYKNPKTG 600
    KYVPSDRISD PSQPVDPDTG DRLEVFFEKM SKSKYNGVDP ARVLDRYGAD 650
    TARMFILFKA PPEKDLEWDD ADVEGQFRFL NRVWRLVQTA SQVEATTAAD 700
    DKAEKDLRRA VHTAIQAFTE DLEEDYQLNT AIAELMKLTN ALNDAPMPGS 750
    PAYLKGVQTL VLLLAPFAPH IAEELWQQLG GERSVHLEGW PVLDESALIV 800
    DEIPLVIQIM GKTRGTITVP ASADRDQLQQ LAKNSEIAQR WLDGQTIRKV 850
    IVVPGKLVNF VIASP 865
    Length:865
    Mass (Da):97,356
    Last modified:February 1, 2005 - v1
    Checksum:i707E35820B4B5539
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD80364.1.
    RefSeqiYP_172884.1. NC_006576.1.

    Genome annotation databases

    EnsemblBacteriaiBAD80364; BAD80364; syc2174_d.
    GeneIDi3199910.
    KEGGisyc:syc2174_d.
    PATRICi32490494. VBISynElo117686_2477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD80364.1 .
    RefSeqi YP_172884.1. NC_006576.1.

    3D structure databases

    ProteinModelPortali Q5N006.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269084.syc2174_d.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD80364 ; BAD80364 ; syc2174_d .
    GeneIDi 3199910.
    KEGGi syc:syc2174_d.
    PATRICi 32490494. VBISynElo117686_2477.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SELO269084:GCDQ-2230-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
      Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
      Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

    Entry informationi

    Entry nameiSYL_SYNP6
    AccessioniPrimary (citable) accession number: Q5N006
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3