SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5N006

- SYL_SYNP6

UniProt

Q5N006 - SYL_SYNP6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene
leuS, syc2174_d
Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-2230-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:syc2174_d
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001175: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Leucine--tRNA ligaseUniRule annotationPRO_0000152103Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269084.syc2174_d.

Structurei

3D structure databases

ProteinModelPortaliQ5N006.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 6811"HIGH" regionUniRule annotationAdd
BLAST
Motifi629 – 6335"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5N006-1 [UniParc]FASTAAdd to Basket

« Hide

MQNGANSRSQ EYQGVSVDSR YDPQAIETKW QQSWAAAQLD RTPEADDRPK    50
FYALSMFPYP SGNLHMGHVR NYTITDAIAR VKRRQGFRVL HAMGWDAFGL 100
PAENAAIDRG VQPADWTYQN VAQMREQLKQ LGLSYDWDRE VTTCSPDYYR 150
WTQWLFLQFF EAGLAYQKEA TVNWDPIDQT VLANEQVDSE GRSWRSGAKV 200
ERRQLKQWFL KITDYAEELL QDLDQLTGWP ERVRLMQANW IGKSTGAYLE 250
FPIVNSSDRV KVFTTRPDTV YGVSYVVLAP EHPLVTQVTT PEQQTAVAAF 300
AAEVSQTSEL ERTAEDRPKR GVPTGGFVTN PFTGQAVPIW IADYVLVEYG 350
TGAVMGVPAH DSRDFAFAQR YGLPVQPVIQ PTEGAIAEPW PAPFTEAGVM 400
VNSGQFDGLS STEAKAKIIA FAEEQGWGQA HVQYRLRDWL ISRQRYWGCP 450
IPIVHCPDCG PVAAADLPVQ LPDSVQFSGR GPSPLAQLED WVTTTCPSCG 500
KPARRETDTM DTFMCSSWYY LRYSDASNPE IAFTKDKVND WLPVDQYVGG 550
IEHAILHLLY SRFFTKVLRD RGLLSFDEPF KRLLTQGMVQ GLTYKNPKTG 600
KYVPSDRISD PSQPVDPDTG DRLEVFFEKM SKSKYNGVDP ARVLDRYGAD 650
TARMFILFKA PPEKDLEWDD ADVEGQFRFL NRVWRLVQTA SQVEATTAAD 700
DKAEKDLRRA VHTAIQAFTE DLEEDYQLNT AIAELMKLTN ALNDAPMPGS 750
PAYLKGVQTL VLLLAPFAPH IAEELWQQLG GERSVHLEGW PVLDESALIV 800
DEIPLVIQIM GKTRGTITVP ASADRDQLQQ LAKNSEIAQR WLDGQTIRKV 850
IVVPGKLVNF VIASP 865
Length:865
Mass (Da):97,356
Last modified:February 1, 2005 - v1
Checksum:i707E35820B4B5539
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80364.1.
RefSeqiYP_172884.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80364; BAD80364; syc2174_d.
GeneIDi3199910.
KEGGisyc:syc2174_d.
PATRICi32490494. VBISynElo117686_2477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80364.1 .
RefSeqi YP_172884.1. NC_006576.1.

3D structure databases

ProteinModelPortali Q5N006.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269084.syc2174_d.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD80364 ; BAD80364 ; syc2174_d .
GeneIDi 3199910.
KEGGi syc:syc2174_d.
PATRICi 32490494. VBISynElo117686_2477.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SELO269084:GCDQ-2230-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
    Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
    Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Entry informationi

Entry nameiSYL_SYNP6
AccessioniPrimary (citable) accession number: Q5N006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi