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Q5MZY3

- LEUC_SYNP6

UniProt

Q5MZY3 - LEUC_SYNP6

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Protein

3-isopropylmalate dehydratase large subunit

Gene
leuC, syc2197_d
Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity.UniRule annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi347 – 3471Iron-sulfur (4Fe-4S) By similarity
Metal bindingi407 – 4071Iron-sulfur (4Fe-4S) By similarity
Metal bindingi410 – 4101Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 3-isopropylmalate dehydratase activity Source: UniProtKB-HAMAP
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-2253-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase large subunit (EC:4.2.1.33)
Alternative name(s):
Alpha-IPM isomerase
Short name:
IPMI
Isopropylmalate isomerase
Gene namesi
Name:leuC
Ordered Locus Names:syc2197_d
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001175: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684683-isopropylmalate dehydratase large subunitUniRule annotationPRO_0000076829Add
BLAST

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi269084.syc2197_d.

Structurei

3D structure databases

ProteinModelPortaliQ5MZY3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0065.
HOGENOMiHOG000226972.
KOiK01703.
OMAiQARAKTM.
OrthoDBiEOG600DP5.

Family and domain databases

Gene3Di3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
HAMAPiMF_01026. LeuC_type1.
InterProiIPR004430. 3-IsopropMal_deHydase_lsu.
IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR00170. leuC. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5MZY3-1 [UniParc]FASTAAdd to Basket

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MSRGTLFDKV WDLHTVATLP SGQTQLFIGL HLIHEVTSPQ AFSMLRDRGL    50
TVKFPGRTVA TVDHIVPTEN QARPFADSLA EEMIVTLERN CRENGIRFYN 100
IGSGSQGIVH VIAPEQGLTQ PGMTIACGDS HTSTHGAFGA IAFGIGTSQV 150
RDVLASQTLA LSKLKVRKIE VNGELQPGVY AKDVILHIIR KLGVKGGVGY 200
AYEFAGSTFA AMSMEERMTV CNMAIEGGAR CGYVNPDQIT YDYLQGREFA 250
PQGEAWDRAI AWWESLRSEA DAEYDDVVVF DAAEIAPTVT WGITPGQGIG 300
ITETIPTPDS LLDEDRAVAA EAYSYMDLEP GAPLQGTKVD VCFIGSCTNG 350
RLSDLREAAK VAQGRKVAAG IKAFVVPGSE RVKQQAEAEG LDQIFTAAGF 400
EWRQAGCSMC LAMNPDKLEG RQISASSSNR NFKGRQGSAS GRTLLMSPAM 450
VAAAAIAGEV TDVRNWLN 468
Length:468
Mass (Da):50,343
Last modified:February 1, 2005 - v1
Checksum:i9D19B242070323BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80387.1.
RefSeqiYP_172907.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80387; BAD80387; syc2197_d.
GeneIDi3199884.
KEGGisyc:syc2197_d.
PATRICi32490540. VBISynElo117686_2500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80387.1 .
RefSeqi YP_172907.1. NC_006576.1.

3D structure databases

ProteinModelPortali Q5MZY3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269084.syc2197_d.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD80387 ; BAD80387 ; syc2197_d .
GeneIDi 3199884.
KEGGi syc:syc2197_d.
PATRICi 32490540. VBISynElo117686_2500.

Phylogenomic databases

eggNOGi COG0065.
HOGENOMi HOG000226972.
KOi K01703.
OMAi QARAKTM.
OrthoDBi EOG600DP5.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00071 .
BioCyci SELO269084:GCDQ-2253-MONOMER.

Family and domain databases

Gene3Di 3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
HAMAPi MF_01026. LeuC_type1.
InterProi IPR004430. 3-IsopropMal_deHydase_lsu.
IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00330. Aconitase. 1 hit.
[Graphical view ]
PRINTSi PR00415. ACONITASE.
SUPFAMi SSF53732. SSF53732. 1 hit.
TIGRFAMsi TIGR00170. leuC. 1 hit.
PROSITEi PS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
    Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
    Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Entry informationi

Entry nameiLEUC_SYNP6
AccessioniPrimary (citable) accession number: Q5MZY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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