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Q5MZV1 (NADK2_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase 2

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase 2
Gene names
Name:nadK2
Ordered Locus Names:syc2229_c
OrganismSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]
Taxonomic identifier269084 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306NAD kinase 2 HAMAP-Rule MF_00361
PRO_0000229702

Regions

Nucleotide binding67 – 682NAD By similarity
Nucleotide binding149 – 1502NAD By similarity

Sites

Active site671Proton acceptor By similarity
Binding site1601NAD By similarity
Binding site1811NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5MZV1 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 53F4F8174C5EFB2D

FASTA30633,423
        10         20         30         40         50         60 
MQLRQVIIAY KAGDPTSKAA ADDCAHCLES QGIHVMLGPS GARDNPFPVF LASATEPIDL 

        70         80         90        100        110        120 
AIVLGGDGTV LAAARHLSDA GIPLLTFNVG GHLGFLTQPR DFFQPEAELW DRLRNDQYAV 

       130        140        150        160        170        180 
EQRMMLAASL HEGGRENREP ISETYYALND MCVKPAAPDR MSVCILEMEV DGEIIDQYQG 

       190        200        210        220        230        240 
DGLIVSTPTG STCYTAAAHG PIVHPGVDAL AVTPICAMSL SSRPIVIPPR SVVSVWPLGT 

       250        260        270        280        290        300 
QDPTIKLWMD GVLATSIWPG QRVDIRMAEK PAQFLVLDSD RSFYRILREK LQWAGAVIHY 


NNNFRN 

« Hide

References

[1]"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008231 Genomic DNA. Translation: BAD80419.1.
RefSeqYP_172939.1. NC_006576.1.

3D structure databases

ProteinModelPortalQ5MZV1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING269084.syc2229_c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD80419; BAD80419; syc2229_c.
GeneID3198700.
KEGGsyc:syc2229_c.
PATRIC32490610. VBISynElo117686_2535.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMAKLHWAGS.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycSELO269084:GCDQ-2285-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK2_SYNP6
AccessionPrimary (citable) accession number: Q5MZV1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families