Q5MZM9 (Q5MZM9_SYNP6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL BAD80491.1
Ordered Locus Names:	syc2301_c

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	198	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	251	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	119	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	121	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	129	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	236	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	208	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	220	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	277	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	316	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q5MZM9 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 0C4F44658CEB37BF	FASTA	326	35,574
	10 20 30 40 50 60 MFPTHRPRRL RSSETLRRMV RETTLTSADF IYPLFAVPGE GVAKEVTSMP GVYQLSIDKI 70 80 90 100 110 120 VEEAKEVYDL GIPSIILFGI PTDKDNDATG AWHDCGIVQK AATAVKEAVP ELIVAADTCL 130 140 150 160 170 180 CEYTPHGHCG YLEVGDLSGR VLNDPTLELL RKTAVSQAKA GADIIAPSGM MDGFVATIRD 190 200 210 220 230 240 ALDEAGFSDT PIMAYSAKYA SAYYGPFRDA AESTPQFGDR RTYQMDPGNS REALKEVELD 250 260 270 280 290 300 VAEGADIVMV KPALSYMDII CRIKETTDLP VAAYNVSGEY SMVKAAALNG WIDEERVVLE 310 320 TLTSFKRAGA DLILTYHAKD AARWLA

References

[1]

"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed: 17211581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008231 Genomic DNA. Translation: BAD80491.1.
RefSeq	YP_173011.1. NC_006576.1.
3D structure databases
ProteinModelPortal	Q5MZM9.
SMR	Q5MZM9. Positions 5-326.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5MZM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3198406.
GenomeReviews	Gene locus syc2301_c in contig AP008231_GR.
KEGG	syc:syc2301_c.
PATRIC	32490770. VBISynElo117686_2615.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0113.
HOGENOM	HBG285270.
OMA	ACGSESM.
PhylomeDB	Q5MZM9.
ProtClustDB	PRK09283.
Enzyme and pathway databases
BioCyc	SELO269084:SYC2301_C-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5MZM9_SYNP6

Accession

Primary (citable) accession number: Q5MZM9

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)