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Q5MZF8

- Q5MZF8_SYNP6

UniProt

Q5MZF8 - Q5MZF8_SYNP6

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-2428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:syc2372_dImported
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)Imported
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001175: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi269084.syc2372_d.

Structurei

3D structure databases

ProteinModelPortaliQ5MZF8.
SMRiQ5MZF8. Positions 4-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5MZF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYEKIQPPSE GSKIRFEAGK PIVPDNPIIP FIRGDGAGVD IWPATERVLD
60 70 80 90 100
AAVAKAYGGQ RKITWFKVYA GDEACDLYGT YQYLPEDTLT AIREYGVAIK
110 120 130 140 150
GPLTTPIGGG IRSLNVALRQ IFDLYACVRP CRYYTGTPSP HRTPEQLDVV
160 170 180 190 200
VYRENTEDIY LGIEWKQGDP TGDRLIKLLN EDFIPNSPSL GKKQIRLDSG
210 220 230 240 250
IGIKPISKTG SQRLIRRAIE HALRLEGRKR HVTLVHKGNI MKFTEGAFRD
260 270 280 290 300
WGYELATTEF RTDCVTERES WILANQESKP DLSLEDNARL IEPGYDAMTP
310 320 330 340 350
EKQAAVVAEV KAVLDSIGAT HGNGQWKSKV LVDDRIADSI FQQIQTRPGE
360 370 380 390 400
YSVLATMNLN GDYISDAAAA VVGGLGMAPG ANIGDEAAIF EATHGAAPKH
410 420 430 440 450
AGLDRINPGS VILSGVMMLE YLGWQEAADL ITKGISQAIA NREVTYDLAR
460 470
LMEPAVDQPL KCSEFAEAIV KHFDD
Length:475
Mass (Da):52,233
Last modified:February 1, 2005 - v1
Checksum:i28B338A22905C8FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80562.1.
RefSeqiYP_173082.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80562; BAD80562; syc2372_d.
GeneIDi3198034.
KEGGisyc:syc2372_d.
PATRICi32490936. VBISynElo117686_2698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80562.1 .
RefSeqi YP_173082.1. NC_006576.1.

3D structure databases

ProteinModelPortali Q5MZF8.
SMRi Q5MZF8. Positions 4-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269084.syc2372_d.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD80562 ; BAD80562 ; syc2372_d .
GeneIDi 3198034.
KEGGi syc:syc2372_d.
PATRICi 32490936. VBISynElo117686_2698.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci SELO269084:GCDQ-2428-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 2 hits.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
    Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
    Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1Imported.

Entry informationi

Entry nameiQ5MZF8_SYNP6
AccessioniPrimary (citable) accession number: Q5MZF8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3