Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-2428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:syc2372_dImported
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)Imported
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001175: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi269084.syc2372_d.

Structurei

3D structure databases

ProteinModelPortaliQ5MZF8.
SMRiQ5MZF8. Positions 4-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5MZF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEKIQPPSE GSKIRFEAGK PIVPDNPIIP FIRGDGAGVD IWPATERVLD
60 70 80 90 100
AAVAKAYGGQ RKITWFKVYA GDEACDLYGT YQYLPEDTLT AIREYGVAIK
110 120 130 140 150
GPLTTPIGGG IRSLNVALRQ IFDLYACVRP CRYYTGTPSP HRTPEQLDVV
160 170 180 190 200
VYRENTEDIY LGIEWKQGDP TGDRLIKLLN EDFIPNSPSL GKKQIRLDSG
210 220 230 240 250
IGIKPISKTG SQRLIRRAIE HALRLEGRKR HVTLVHKGNI MKFTEGAFRD
260 270 280 290 300
WGYELATTEF RTDCVTERES WILANQESKP DLSLEDNARL IEPGYDAMTP
310 320 330 340 350
EKQAAVVAEV KAVLDSIGAT HGNGQWKSKV LVDDRIADSI FQQIQTRPGE
360 370 380 390 400
YSVLATMNLN GDYISDAAAA VVGGLGMAPG ANIGDEAAIF EATHGAAPKH
410 420 430 440 450
AGLDRINPGS VILSGVMMLE YLGWQEAADL ITKGISQAIA NREVTYDLAR
460 470
LMEPAVDQPL KCSEFAEAIV KHFDD
Length:475
Mass (Da):52,233
Last modified:February 1, 2005 - v1
Checksum:i28B338A22905C8FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008231 Genomic DNA. Translation: BAD80562.1.
RefSeqiYP_173082.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80562; BAD80562; syc2372_d.
GeneIDi3198034.
KEGGisyc:syc2372_d.
PATRICi32490936. VBISynElo117686_2698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008231 Genomic DNA. Translation: BAD80562.1.
RefSeqiYP_173082.1. NC_006576.1.

3D structure databases

ProteinModelPortaliQ5MZF8.
SMRiQ5MZF8. Positions 4-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269084.syc2372_d.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD80562; BAD80562; syc2372_d.
GeneIDi3198034.
KEGGisyc:syc2372_d.
PATRICi32490936. VBISynElo117686_2698.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-2428-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
    Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
    Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1Imported.

Entry informationi

Entry nameiQ5MZF8_SYNP6
AccessioniPrimary (citable) accession number: Q5MZF8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: March 4, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.