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Q5MZA4

- SYC_SYNP6

UniProt

Q5MZA4 - SYC_SYNP6

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Protein
Cysteine--tRNA ligase
Gene
cysS, syc2426_d
Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Zinc By similarity
Metal bindingi213 – 2131Zinc By similarity
Metal bindingi238 – 2381Zinc By similarity
Metal bindingi242 – 2421Zinc By similarity
Binding sitei273 – 2731ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-2482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:syc2426_d
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001175: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Cysteine--tRNA ligaseUniRule annotation
PRO_0000159503Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi269084.syc2426_d.

Structurei

3D structure databases

ProteinModelPortaliQ5MZA4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi31 – 4111"HIGH" regionUniRule annotation
Add
BLAST
Motifi270 – 2745"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0215.
HOGENOMiHOG000245250.
KOiK01883.
OMAiMHADFDA.
OrthoDBiEOG6RVFXC.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5MZA4-1 [UniParc]FASTAAdd to Basket

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MTLSLYNTLT RQKQRFEPLQ AGSVSLYCCG VTVYDYCHLG HARSYIVWDT    50
LRRYLLWLGY RVRYVQNFTD IDDKILRRSR QEGTTMQAIA DRYTQAYFED 100
MARLNILEAD DYPRATHTLD GIQRLIAELE DKGFAYAADG DVYFSVRRFQ 150
DYGKLSGRKL EDLKAGASGR VESAEESLKH DPFDFALWKA AKPEEPAWDS 200
PWGPGRPGWH IECSAMVRDR LGDSIDIHVG GADLVFPHHE NEIAQSEAVT 250
GHPLARYWLH NGMVNVGGEK MSKSLGNFTT IRQLLDEGGI SPMVLRLFVL 300
QANYRKPIDF TDEALQACQN GWETLQEGLH FGEHWGDRLG WTESVTVDPD 350
LSDRFRMAMD DDLNTPAALA VLFELAKELR RQQNLLIHEG HLDGDAQQLH 400
QHWVTLVQLA GVLGLEAEPE LAETNELDEA AIEDWIAKRH AARQAKDFAE 450
ADRIRHYLAD LGITLIDQAG GITRWSRT 478
Length:478
Mass (Da):54,360
Last modified:February 1, 2005 - v1
Checksum:i76228D430A61E0EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80616.1.
RefSeqiWP_011244736.1. NC_006576.1.
YP_173136.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80616; BAD80616; syc2426_d.
GeneIDi3199160.
KEGGisyc:syc2426_d.
PATRICi32491058. VBISynElo117686_2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008231 Genomic DNA. Translation: BAD80616.1 .
RefSeqi WP_011244736.1. NC_006576.1.
YP_173136.1. NC_006576.1.

3D structure databases

ProteinModelPortali Q5MZA4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269084.syc2426_d.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD80616 ; BAD80616 ; syc2426_d .
GeneIDi 3199160.
KEGGi syc:syc2426_d.
PATRICi 32491058. VBISynElo117686_2759.

Phylogenomic databases

eggNOGi COG0215.
HOGENOMi HOG000245250.
KOi K01883.
OMAi MHADFDA.
OrthoDBi EOG6RVFXC.

Enzyme and pathway databases

BioCyci SELO269084:GCDQ-2482-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00041. Cys_tRNA_synth.
InterProi IPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR10890. PTHR10890. 1 hit.
Pfami PF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00983. TRNASYNTHCYS.
SMARTi SM00840. DALR_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00435. cysS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
    Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
    Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Entry informationi

Entry nameiSYC_SYNP6
AccessioniPrimary (citable) accession number: Q5MZA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 1, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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