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Q5MZA4 (SYC_SYNP6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine--tRNA ligase

EC=6.1.1.16
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name=CysRS
Gene names
Name:cysS
Ordered Locus Names:syc2426_d
OrganismSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]
Taxonomic identifier269084 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP-Rule MF_00041

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00041

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00041

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00041.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcysteinyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cysteine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Cysteine--tRNA ligase HAMAP-Rule MF_00041
PRO_0000159503

Regions

Motif31 – 4111"HIGH" region HAMAP-Rule MF_00041
Motif270 – 2745"KMSKS" region HAMAP-Rule MF_00041

Sites

Metal binding291Zinc By similarity
Metal binding2131Zinc By similarity
Metal binding2381Zinc By similarity
Metal binding2421Zinc By similarity
Binding site2731ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5MZA4 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 76228D430A61E0EB

FASTA47854,360
        10         20         30         40         50         60 
MTLSLYNTLT RQKQRFEPLQ AGSVSLYCCG VTVYDYCHLG HARSYIVWDT LRRYLLWLGY 

        70         80         90        100        110        120 
RVRYVQNFTD IDDKILRRSR QEGTTMQAIA DRYTQAYFED MARLNILEAD DYPRATHTLD 

       130        140        150        160        170        180 
GIQRLIAELE DKGFAYAADG DVYFSVRRFQ DYGKLSGRKL EDLKAGASGR VESAEESLKH 

       190        200        210        220        230        240 
DPFDFALWKA AKPEEPAWDS PWGPGRPGWH IECSAMVRDR LGDSIDIHVG GADLVFPHHE 

       250        260        270        280        290        300 
NEIAQSEAVT GHPLARYWLH NGMVNVGGEK MSKSLGNFTT IRQLLDEGGI SPMVLRLFVL 

       310        320        330        340        350        360 
QANYRKPIDF TDEALQACQN GWETLQEGLH FGEHWGDRLG WTESVTVDPD LSDRFRMAMD 

       370        380        390        400        410        420 
DDLNTPAALA VLFELAKELR RQQNLLIHEG HLDGDAQQLH QHWVTLVQLA GVLGLEAEPE 

       430        440        450        460        470 
LAETNELDEA AIEDWIAKRH AARQAKDFAE ADRIRHYLAD LGITLIDQAG GITRWSRT 

« Hide

References

[1]"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008231 Genomic DNA. Translation: BAD80616.1.
RefSeqYP_173136.1. NC_006576.1.

3D structure databases

ProteinModelPortalQ5MZA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING269084.syc2426_d.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD80616; BAD80616; syc2426_d.
GeneID3199160.
KEGGsyc:syc2426_d.
PATRIC32491058. VBISynElo117686_2759.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0215.
HOGENOMHOG000245250.
KOK01883.
OMAMHADFDA.
OrthoDBEOG6RVFXC.

Enzyme and pathway databases

BioCycSELO269084:GCDQ-2482-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00041. Cys_tRNA_synth.
InterProIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR10890. PTHR10890. 1 hit.
PfamPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
SMARTSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00435. cysS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYC_SYNP6
AccessionPrimary (citable) accession number: Q5MZA4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries