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Q5MZA4

- SYC_SYNP6

UniProt

Q5MZA4 - SYC_SYNP6

Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi29 – 291ZincUniRule annotation
    Metal bindingi213 – 2131ZincUniRule annotation
    Metal bindingi238 – 2381ZincUniRule annotation
    Metal bindingi242 – 2421ZincUniRule annotation
    Binding sitei273 – 2731ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSELO269084:GCDQ-2482-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
    Alternative name(s):
    Cysteinyl-tRNA synthetaseUniRule annotation
    Short name:
    CysRSUniRule annotation
    Gene namesi
    Name:cysSUniRule annotation
    Ordered Locus Names:syc2426_d
    OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
    Taxonomic identifieri269084 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001175: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Cysteine--tRNA ligasePRO_0000159503Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi269084.syc2426_d.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5MZA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi31 – 4111"HIGH" regionAdd
    BLAST
    Motifi270 – 2745"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0215.
    HOGENOMiHOG000245250.
    KOiK01883.
    OMAiMHADFDA.
    OrthoDBiEOG6RVFXC.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00041. Cys_tRNA_synth.
    InterProiIPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR10890. PTHR10890. 1 hit.
    PfamiPF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view]
    PRINTSiPR00983. TRNASYNTHCYS.
    SMARTiSM00840. DALR_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00435. cysS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5MZA4-1 [UniParc]FASTAAdd to Basket

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    MTLSLYNTLT RQKQRFEPLQ AGSVSLYCCG VTVYDYCHLG HARSYIVWDT    50
    LRRYLLWLGY RVRYVQNFTD IDDKILRRSR QEGTTMQAIA DRYTQAYFED 100
    MARLNILEAD DYPRATHTLD GIQRLIAELE DKGFAYAADG DVYFSVRRFQ 150
    DYGKLSGRKL EDLKAGASGR VESAEESLKH DPFDFALWKA AKPEEPAWDS 200
    PWGPGRPGWH IECSAMVRDR LGDSIDIHVG GADLVFPHHE NEIAQSEAVT 250
    GHPLARYWLH NGMVNVGGEK MSKSLGNFTT IRQLLDEGGI SPMVLRLFVL 300
    QANYRKPIDF TDEALQACQN GWETLQEGLH FGEHWGDRLG WTESVTVDPD 350
    LSDRFRMAMD DDLNTPAALA VLFELAKELR RQQNLLIHEG HLDGDAQQLH 400
    QHWVTLVQLA GVLGLEAEPE LAETNELDEA AIEDWIAKRH AARQAKDFAE 450
    ADRIRHYLAD LGITLIDQAG GITRWSRT 478
    Length:478
    Mass (Da):54,360
    Last modified:February 1, 2005 - v1
    Checksum:i76228D430A61E0EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD80616.1.
    RefSeqiWP_011244736.1. NC_006576.1.
    YP_173136.1. NC_006576.1.

    Genome annotation databases

    EnsemblBacteriaiBAD80616; BAD80616; syc2426_d.
    GeneIDi3199160.
    KEGGisyc:syc2426_d.
    PATRICi32491058. VBISynElo117686_2759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD80616.1 .
    RefSeqi WP_011244736.1. NC_006576.1.
    YP_173136.1. NC_006576.1.

    3D structure databases

    ProteinModelPortali Q5MZA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269084.syc2426_d.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD80616 ; BAD80616 ; syc2426_d .
    GeneIDi 3199160.
    KEGGi syc:syc2426_d.
    PATRICi 32491058. VBISynElo117686_2759.

    Phylogenomic databases

    eggNOGi COG0215.
    HOGENOMi HOG000245250.
    KOi K01883.
    OMAi MHADFDA.
    OrthoDBi EOG6RVFXC.

    Enzyme and pathway databases

    BioCyci SELO269084:GCDQ-2482-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00041. Cys_tRNA_synth.
    InterProi IPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR10890. PTHR10890. 1 hit.
    Pfami PF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view ]
    PRINTSi PR00983. TRNASYNTHCYS.
    SMARTi SM00840. DALR_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00435. cysS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
      Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
      Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

    Entry informationi

    Entry nameiSYC_SYNP6
    AccessioniPrimary (citable) accession number: Q5MZA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3