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Q5MZ26

- HISX_SYNP6

UniProt

Q5MZ26 - HISX_SYNP6

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADUniRule annotation
Binding sitei192 – 1921NADUniRule annotation
Binding sitei215 – 2151NADUniRule annotation
Binding sitei238 – 2381SubstrateUniRule annotation
Metal bindingi260 – 2601ZincUniRule annotation
Binding sitei260 – 2601SubstrateUniRule annotation
Metal bindingi263 – 2631ZincUniRule annotation
Binding sitei263 – 2631SubstrateUniRule annotation
Active sitei328 – 3281Proton acceptorUniRule annotation
Active sitei329 – 3291Proton acceptorUniRule annotation
Binding sitei329 – 3291SubstrateUniRule annotation
Metal bindingi362 – 3621ZincUniRule annotation
Binding sitei362 – 3621SubstrateUniRule annotation
Binding sitei416 – 4161SubstrateUniRule annotation
Metal bindingi421 – 4211ZincUniRule annotation
Binding sitei421 – 4211SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-2562-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:syc2504_c
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001175: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenasePRO_0000135863Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269084.syc2504_c.

Structurei

3D structure databases

ProteinModelPortaliQ5MZ26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5MZ26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRIVSHLAE AQAELERICD RTHDDAVVHR EASVREIVQA VQRRGDAALI
60 70 80 90 100
EFTQEFDGFA LQAENLRVSG AELDAAYQQI PKELLDAIRL AHHQIEAFHR
110 120 130 140 150
QRVPKSWVQF GADGEVLGKR YTPVDRAGLY VPGGRAAYPS TVLMNAVPAK
160 170 180 190 200
VAGVERVVIT TPPGPDGSLN PAVLVAAQEA GIEEIYRVGG AQAIAALAYG
210 220 230 240 250
TATIPKVDVI SGPGNIYVTL AKKLVYGTVG IDSLAGPSEV LIIADRSANP
260 270 280 290 300
RWVAADLLAQ AEHDPLAAAI LITPDLELAT QVGFEVERQL QDHPRRLVTE
310 320 330 340 350
KAIAHYGLAI VVDSLETAVK LSNQFAPEHL ELEVEDPWAL VEQVRHAGAI
360 370 380 390 400
FLGSLTPEAI GDYVAGPNHT LPTSGAARYA SALSVETFLK SSSLIEYTAA
410 420 430
SLQRVARAVD VLATAEGLES HAESVRLRQQ SLDR
Length:434
Mass (Da):46,652
Last modified:February 1, 2005 - v1
Checksum:iF9880888CAC2B8B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008231 Genomic DNA. Translation: BAD80694.1.
RefSeqiWP_011244814.1. NC_006576.1.
YP_173214.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80694; BAD80694; syc2504_c.
GeneIDi3199002.
KEGGisyc:syc2504_c.
PATRICi32491234. VBISynElo117686_2846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008231 Genomic DNA. Translation: BAD80694.1 .
RefSeqi WP_011244814.1. NC_006576.1.
YP_173214.1. NC_006576.1.

3D structure databases

ProteinModelPortali Q5MZ26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269084.syc2504_c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD80694 ; BAD80694 ; syc2504_c .
GeneIDi 3199002.
KEGGi syc:syc2504_c.
PATRICi 32491234. VBISynElo117686_2846.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SELO269084:GCDQ-2562-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
    Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
    Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Entry informationi

Entry nameiHISX_SYNP6
AccessioniPrimary (citable) accession number: Q5MZ26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3