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Q5MZ26

- HISX_SYNP6

UniProt

Q5MZ26 - HISX_SYNP6

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301NADUniRule annotation
    Binding sitei192 – 1921NADUniRule annotation
    Binding sitei215 – 2151NADUniRule annotation
    Binding sitei238 – 2381SubstrateUniRule annotation
    Metal bindingi260 – 2601ZincUniRule annotation
    Binding sitei260 – 2601SubstrateUniRule annotation
    Metal bindingi263 – 2631ZincUniRule annotation
    Binding sitei263 – 2631SubstrateUniRule annotation
    Active sitei328 – 3281Proton acceptorUniRule annotation
    Active sitei329 – 3291Proton acceptorUniRule annotation
    Binding sitei329 – 3291SubstrateUniRule annotation
    Metal bindingi362 – 3621ZincUniRule annotation
    Binding sitei362 – 3621SubstrateUniRule annotation
    Binding sitei416 – 4161SubstrateUniRule annotation
    Metal bindingi421 – 4211ZincUniRule annotation
    Binding sitei421 – 4211SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSELO269084:GCDQ-2562-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:syc2504_c
    OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
    Taxonomic identifieri269084 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001175: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Histidinol dehydrogenasePRO_0000135863Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269084.syc2504_c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5MZ26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5MZ26-1 [UniParc]FASTAAdd to Basket

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    MLRIVSHLAE AQAELERICD RTHDDAVVHR EASVREIVQA VQRRGDAALI    50
    EFTQEFDGFA LQAENLRVSG AELDAAYQQI PKELLDAIRL AHHQIEAFHR 100
    QRVPKSWVQF GADGEVLGKR YTPVDRAGLY VPGGRAAYPS TVLMNAVPAK 150
    VAGVERVVIT TPPGPDGSLN PAVLVAAQEA GIEEIYRVGG AQAIAALAYG 200
    TATIPKVDVI SGPGNIYVTL AKKLVYGTVG IDSLAGPSEV LIIADRSANP 250
    RWVAADLLAQ AEHDPLAAAI LITPDLELAT QVGFEVERQL QDHPRRLVTE 300
    KAIAHYGLAI VVDSLETAVK LSNQFAPEHL ELEVEDPWAL VEQVRHAGAI 350
    FLGSLTPEAI GDYVAGPNHT LPTSGAARYA SALSVETFLK SSSLIEYTAA 400
    SLQRVARAVD VLATAEGLES HAESVRLRQQ SLDR 434
    Length:434
    Mass (Da):46,652
    Last modified:February 1, 2005 - v1
    Checksum:iF9880888CAC2B8B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD80694.1.
    RefSeqiYP_173214.1. NC_006576.1.

    Genome annotation databases

    EnsemblBacteriaiBAD80694; BAD80694; syc2504_c.
    GeneIDi3199002.
    KEGGisyc:syc2504_c.
    PATRICi32491234. VBISynElo117686_2846.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008231 Genomic DNA. Translation: BAD80694.1 .
    RefSeqi YP_173214.1. NC_006576.1.

    3D structure databases

    ProteinModelPortali Q5MZ26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269084.syc2504_c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD80694 ; BAD80694 ; syc2504_c .
    GeneIDi 3199002.
    KEGGi syc:syc2504_c.
    PATRICi 32491234. VBISynElo117686_2846.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SELO269084:GCDQ-2562-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
      Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
      Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

    Entry informationi

    Entry nameiHISX_SYNP6
    AccessioniPrimary (citable) accession number: Q5MZ26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3