Q5MXJ1 (Q5MXJ1_MACMU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Toll-like receptor 2 EMBL AAS17868.1

Gene names

Name:

TLR2 EMBL AAS17868.1

Organism

Macaca mulatta (Rhesus macaque) EMBL AAS17868.1

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	145 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 TIR domain. SAAS SAAS000157

Ontologies

Keywords
Molecular function	Receptor EMBL AAS17868.1
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: InterPro innate immune response Inferred from electronic annotation. Source: InterPro positive regulation of inflammatory response Inferred from electronic annotation. Source: InterPro regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro response to molecule of bacterial origin Inferred from electronic annotation. Source: InterPro toll-like receptor 2 signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAS17868.1
	Non-terminal residue	145	1	EMBL AAS17868.1

Sequences

	Sequence		Length	Mass (Da)
	Q5MXJ1 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 5FC89A6B28019A9B	FASTA	145	17,358
	10 20 30 40 50 60 CYDAFVSYSE RDAYWVENLM VQELENFNPP FKLCLHKRDF IPGKWIIDNI IDSIEKSHKT 70 80 90 100 110 120 VFVLSENFVK SEWCKYELDF SHFRLFDENN DAAILVLLEP IEKKAIPRRS CKLRKIMNTK 130 140 TYLEWPMDEA RQEGFWVNLR AAIKS

References

[1]

"Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences." Sanghavi S.K., Shankarappa R., Reinhart T.A. Immunogenetics 56:667-674(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY525612 mRNA. Translation: AAS17868.1.
UniGene	Mmu.3812.
3D structure databases
ProteinModelPortal	Q5MXJ1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG072893.
InParanoid	Q5MXJ1.
Family and domain databases
InterPro	IPR000157. TIR_dom. IPR027185. TLR2. [Graphical view]
PANTHER	PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
SMART	SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5MXJ1_MACMU

Accession

Primary (citable) accession number: Q5MXJ1

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)