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Q5MNZ9

- WIPI1_HUMAN

UniProt

Q5MNZ9 - WIPI1_HUMAN

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Protein

WD repeat domain phosphoinositide-interacting protein 1

Gene

WIPI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.8 Publications

GO - Molecular functioni

  1. androgen receptor binding Source: UniProtKB
  2. estrogen receptor binding Source: UniProtKB
  3. phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
  4. phosphatidylinositol-3-phosphate binding Source: UniProtKB
  5. receptor binding Source: MGI

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. autophagy Source: UniProtKB
  3. cellular protein metabolic process Source: Reactome
  4. endoplasmic reticulum unfolded protein response Source: Reactome
  5. vesicle targeting, trans-Golgi to endosome Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.
SignaLinkiQ5MNZ9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain phosphoinositide-interacting protein 1
Short name:
WIPI-1
Alternative name(s):
Atg18 protein homolog
WD40 repeat protein interacting with phosphoinositides of 49 kDa
Short name:
WIPI 49 kDa
Gene namesi
Name:WIPI1
Synonyms:WIPI49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25471. WIPI1.

Subcellular locationi

Golgi apparatustrans-Golgi network. Endosome. Cytoplasmic vesicleclathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasmcytoskeleton
Note: Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.

GO - Cellular componenti

  1. autophagic vacuole membrane Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic vesicle Source: UniProtKB-KW
  4. cytoskeleton Source: UniProtKB-KW
  5. endosome membrane Source: UniProtKB
  6. Golgi membrane Source: Reactome
  7. pre-autophagosomal structure Source: MGI
  8. pre-autophagosomal structure membrane Source: UniProtKB
  9. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi203 – 2031S → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi205 – 2051S → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi208 – 2081G → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi209 – 2091T → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi212 – 2121R → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi226 – 2272RR → AA: Loss of binding to phosphoinositides, does not disrupt the MPR pathway. 1 Publication
Mutagenesisi226 – 2261R → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi227 – 2271R → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi228 – 2281G → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi251 – 2511S → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi255 – 2551T → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication
Mutagenesisi257 – 2571H → A: Loss of binding to phosphoinositides and abolishes puncta formation. 1 Publication

Organism-specific databases

PharmGKBiPA142670575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446WD repeat domain phosphoinositide-interacting protein 1PRO_0000051437Add
BLAST

Proteomic databases

MaxQBiQ5MNZ9.
PaxDbiQ5MNZ9.
PRIDEiQ5MNZ9.

PTM databases

PhosphoSiteiQ5MNZ9.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues.1 Publication

Gene expression databases

BgeeiQ5MNZ9.
CleanExiHS_WIPI1.
ExpressionAtlasiQ5MNZ9. baseline and differential.
GenevestigatoriQ5MNZ9.

Organism-specific databases

HPAiCAB037230.
HPA007493.

Interactioni

Subunit structurei

Interacts with androgen receptor (AR) and the estrogen receptors ESR1 and ESR2. Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes.1 Publication

Protein-protein interaction databases

BioGridi120380. 12 interactions.
IntActiQ5MNZ9. 7 interactions.
MINTiMINT-1392030.
STRINGi9606.ENSP00000262139.

Structurei

3D structure databases

ProteinModelPortaliQ5MNZ9.
SMRiQ5MNZ9. Positions 20-261, 322-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati184 – 22441WD 1Add
BLAST
Repeati230 – 26940WD 2Add
BLAST
Repeati312 – 35140WD 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1366Nuclear receptor interaction

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P).1 Publication

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 3 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317564.
GeneTreeiENSGT00730000110845.
HOGENOMiHOG000217544.
HOVERGENiHBG056639.
InParanoidiQ5MNZ9.
KOiK17908.
OMAiILCRGSQ.
PhylomeDBiQ5MNZ9.
TreeFamiTF314879.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5MNZ9-1) [UniParc]FASTAAdd to Basket

Also known as: WIPI-1 alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAEAADAPP GGVESALSCF SFNQDCTSLA TGTKAGYKLF SLSSVEQLDQ
60 70 80 90 100
VHGSNEIPDV YIVERLFSSS LVVVVSHTKP RQMNVYHFKK GTEICNYSYS
110 120 130 140 150
SNILSIRLNR QRLLVCLEES IYIHNIKDMK LLKTLLDIPA NPTGLCALSI
160 170 180 190 200
NHSNSYLAYP GSLTSGEIVL YDGNSLKTVC TIAAHEGTLA AITFNASGSK
210 220 230 240 250
LASASEKGTV IRVFSVPDGQ KLYEFRRGMK RYVTISSLVF SMDSQFLCAS
260 270 280 290 300
SNTETVHIFK LEQVTNSRPE EPSTWSGYMG KMFMAATNYL PTQVSDMMHQ
310 320 330 340 350
DRAFATARLN FSGQRNICTL STIQKLPRLL VASSSGHLYM YNLDPQDGGE
360 370 380 390 400
CVLIKTHSLL GSGTTEENKE NDLRPSLPQS YAATVARPSA SSASTVPGYS
410 420 430 440
EDGGALRGEV IPEHEFATGP VCLDDENEFP PIILCRGNQK GKTKQS
Length:446
Mass (Da):48,673
Last modified:May 1, 2007 - v3
Checksum:i35B5650990B62E31
GO
Isoform 2 (identifier: Q5MNZ9-2) [UniParc]FASTAAdd to Basket

Also known as: WIPI-1 beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MEAEAA → M

Show »
Length:441
Mass (Da):48,202
Checksum:i969C220C162DC7F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631V → A in AAV80760. (PubMed:15602573)Curated
Sequence conflicti249 – 2491A → AA in AAV80760. (PubMed:15602573)Curated
Sequence conflicti358 – 3581S → R in BAA91423. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311T → I.2 Publications
Corresponds to variant rs883541 [ dbSNP | Ensembl ].
VAR_024848
Natural varianti308 – 3081R → H.
Corresponds to variant rs36084378 [ dbSNP | Ensembl ].
VAR_053439

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MEAEAA → M in isoform 2. 1 PublicationVSP_016966

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691424 mRNA. Translation: AAV80760.1.
AK000917 mRNA. Translation: BAA91423.1.
AC007780 Genomic DNA. No translation available.
BC039867 mRNA. Translation: AAH39867.1.
CCDSiCCDS11677.1. [Q5MNZ9-1]
RefSeqiNP_060453.3. NM_017983.5. [Q5MNZ9-1]
UniGeneiHs.463964.

Genome annotation databases

EnsembliENST00000262139; ENSP00000262139; ENSG00000070540. [Q5MNZ9-1]
GeneIDi55062.
KEGGihsa:55062.
UCSCiuc010dey.3. human. [Q5MNZ9-1]

Polymorphism databases

DMDMi146291100.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691424 mRNA. Translation: AAV80760.1 .
AK000917 mRNA. Translation: BAA91423.1 .
AC007780 Genomic DNA. No translation available.
BC039867 mRNA. Translation: AAH39867.1 .
CCDSi CCDS11677.1. [Q5MNZ9-1 ]
RefSeqi NP_060453.3. NM_017983.5. [Q5MNZ9-1 ]
UniGenei Hs.463964.

3D structure databases

ProteinModelPortali Q5MNZ9.
SMRi Q5MNZ9. Positions 20-261, 322-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120380. 12 interactions.
IntActi Q5MNZ9. 7 interactions.
MINTi MINT-1392030.
STRINGi 9606.ENSP00000262139.

PTM databases

PhosphoSitei Q5MNZ9.

Polymorphism databases

DMDMi 146291100.

Proteomic databases

MaxQBi Q5MNZ9.
PaxDbi Q5MNZ9.
PRIDEi Q5MNZ9.

Protocols and materials databases

DNASUi 55062.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262139 ; ENSP00000262139 ; ENSG00000070540 . [Q5MNZ9-1 ]
GeneIDi 55062.
KEGGi hsa:55062.
UCSCi uc010dey.3. human. [Q5MNZ9-1 ]

Organism-specific databases

CTDi 55062.
GeneCardsi GC17M066417.
H-InvDB HIX0014115.
HGNCi HGNC:25471. WIPI1.
HPAi CAB037230.
HPA007493.
MIMi 609224. gene.
neXtProti NX_Q5MNZ9.
PharmGKBi PA142670575.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317564.
GeneTreei ENSGT00730000110845.
HOGENOMi HOG000217544.
HOVERGENi HBG056639.
InParanoidi Q5MNZ9.
KOi K17908.
OMAi ILCRGSQ.
PhylomeDBi Q5MNZ9.
TreeFami TF314879.

Enzyme and pathway databases

Reactomei REACT_18273. XBP1(S) activates chaperone genes.
SignaLinki Q5MNZ9.

Miscellaneous databases

ChiTaRSi WIPI1. human.
GeneWikii WIPI1.
GenomeRNAii 55062.
NextBioi 58557.
PROi Q5MNZ9.
SOURCEi Search...

Gene expression databases

Bgeei Q5MNZ9.
CleanExi HS_WIPI1.
ExpressionAtlasi Q5MNZ9. baseline and differential.
Genevestigatori Q5MNZ9.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 2 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."
    Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A.
    Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AR; ESR1 AND ESR2, SUBCELLULAR LOCATION, VARIANT ILE-31.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-31.
    Tissue: Skin.
  5. "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49."
    Jeffries T.R., Dove S.K., Michell R.H., Parker P.J.
    Mol. Biol. Cell 15:2652-2663(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, BINDING TO PHOSPHOINOSITIDES, MUTAGENESIS OF 226-ARG-ARG-227.
  6. "Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy."
    Proikas-Cezanne T., Ruckerbauer S., Stierhof Y.D., Berg C., Nordheim A.
    FEBS Lett. 581:3396-3404(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy."
    Vergne I., Roberts E., Elmaoued R.A., Tosch V., Delgado M.A., Proikas-Cezanne T., Laporte J., Deretic V.
    EMBO J. 28:2244-2258(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins."
    Itakura E., Mizushima N.
    Autophagy 6:764-776(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. "Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation."
    Geeraert C., Ratier A., Pfisterer S.G., Perdiz D., Cantaloube I., Rouault A., Pattingre S., Proikas-Cezanne T., Codogno P., Pous C.
    J. Biol. Chem. 285:24184-24194(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MICROTUBULE-BINDING.
  11. "The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells."
    Gao P., Bauvy C., Souquere S., Tonelli G., Liu L., Zhu Y., Qiao Z., Bakula D., Proikas-Cezanne T., Pierron G., Codogno P., Chen Q., Mehrpour M.
    J. Biol. Chem. 285:25570-25581(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy."
    Taguchi-Atarashi N., Hamasaki M., Matsunaga K., Omori H., Ktistakis N.T., Yoshimori T., Noda T.
    Traffic 11:468-478(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition."
    Ho H., Kapadia R., Al-Tahan S., Ahmad S., Ganesan A.K.
    J. Biol. Chem. 286:12509-12523(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes."
    Proikas-Cezanne T., Robenek H.
    J. Cell. Mol. Med. 15:2007-2010(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  15. "Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy."
    Pfisterer S.G., Mauthe M., Codogno P., Proikas-Cezanne T.
    Mol. Pharmacol. 80:1066-1075(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION BY CALCIUM-SIGNALING, SUBCELLULAR LOCATION.
  16. "WIPI-1 positive autophagosome-like vesicles entrap pathogenic Staphylococcus aureus for lysosomal degradation."
    Mauthe M., Yu W., Krut O., Kronke M., Gotz F., Robenek H., Proikas-Cezanne T.
    Int. J. Cell Biol. 2012:179207-179207(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 beta-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition."
    Gaugel A., Bakula D., Hoffmann A., Proikas-Cezanne T.
    J. Mol. Signal. 7:16-16(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN, PIP2-BINDING, MUTAGENESIS OF SER-203; SER-205; GLY-208; THR-209; ARG-212; ARG-226; ARG-227; GLY-228; SER-251; THR-255 AND HIS-257.

Entry informationi

Entry nameiWIPI1_HUMAN
AccessioniPrimary (citable) accession number: Q5MNZ9
Secondary accession number(s): Q8IXM5, Q9NWF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: May 1, 2007
Last modified: November 26, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3