Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5MNZ9

- WIPI1_HUMAN

UniProt

Q5MNZ9 - WIPI1_HUMAN

Protein

WD repeat domain phosphoinositide-interacting protein 1

Gene

WIPI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (01 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.8 Publications

    GO - Molecular functioni

    1. androgen receptor binding Source: UniProtKB
    2. estrogen receptor binding Source: UniProtKB
    3. phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
    4. phosphatidylinositol-3-phosphate binding Source: UniProtKB
    5. receptor binding Source: MGI

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. autophagy Source: UniProtKB
    3. cellular protein metabolic process Source: Reactome
    4. endoplasmic reticulum unfolded protein response Source: Reactome
    5. vesicle targeting, trans-Golgi to endosome Source: UniProtKB

    Keywords - Biological processi

    Autophagy

    Enzyme and pathway databases

    ReactomeiREACT_18273. XBP1(S) activates chaperone genes.
    SignaLinkiQ5MNZ9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 1
    Short name:
    WIPI-1
    Alternative name(s):
    Atg18 protein homolog
    WD40 repeat protein interacting with phosphoinositides of 49 kDa
    Short name:
    WIPI 49 kDa
    Gene namesi
    Name:WIPI1
    Synonyms:WIPI49
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25471. WIPI1.

    Subcellular locationi

    Golgi apparatustrans-Golgi network. Endosome. Cytoplasmic vesicleclathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasmcytoskeleton
    Note: Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.

    GO - Cellular componenti

    1. autophagic vacuole membrane Source: UniProtKB
    2. clathrin-coated vesicle Source: UniProtKB-SubCell
    3. cytoplasm Source: UniProtKB
    4. cytoskeleton Source: UniProtKB-SubCell
    5. endosome membrane Source: UniProtKB
    6. Golgi membrane Source: Reactome
    7. pre-autophagosomal structure Source: MGI
    8. pre-autophagosomal structure membrane Source: UniProtKB
    9. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi203 – 2031S → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi205 – 2051S → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi208 – 2081G → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi209 – 2091T → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi212 – 2121R → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi226 – 2272RR → AA: Loss of binding to phosphoinositides, does not disrupt the MPR pathway. 2 Publications
    Mutagenesisi226 – 2261R → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi227 – 2271R → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi228 – 2281G → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi251 – 2511S → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi255 – 2551T → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications
    Mutagenesisi257 – 2571H → A: Loss of binding to phosphoinositides and abolishes puncta formation. 2 Publications

    Organism-specific databases

    PharmGKBiPA142670575.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446WD repeat domain phosphoinositide-interacting protein 1PRO_0000051437Add
    BLAST

    Proteomic databases

    MaxQBiQ5MNZ9.
    PaxDbiQ5MNZ9.
    PRIDEiQ5MNZ9.

    PTM databases

    PhosphoSiteiQ5MNZ9.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ5MNZ9.
    BgeeiQ5MNZ9.
    CleanExiHS_WIPI1.
    GenevestigatoriQ5MNZ9.

    Organism-specific databases

    HPAiCAB037230.
    HPA007493.

    Interactioni

    Subunit structurei

    Interacts with androgen receptor (AR) and the estrogen receptors ESR1 and ESR2. Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes.1 Publication

    Protein-protein interaction databases

    BioGridi120380. 5 interactions.
    IntActiQ5MNZ9. 7 interactions.
    MINTiMINT-1392030.
    STRINGi9606.ENSP00000262139.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5MNZ9.
    SMRiQ5MNZ9. Positions 20-261, 316-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati184 – 22441WD 1Add
    BLAST
    Repeati230 – 26940WD 2Add
    BLAST
    Repeati312 – 35140WD 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi131 – 1366Nuclear receptor interaction

    Domaini

    The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P).1 Publication

    Sequence similaritiesi

    Belongs to the WD repeat SVP1 family.Curated
    Contains 3 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG317564.
    HOGENOMiHOG000217544.
    HOVERGENiHBG056639.
    InParanoidiQ5MNZ9.
    KOiK17908.
    OMAiILCRGSQ.
    PhylomeDBiQ5MNZ9.
    TreeFamiTF314879.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5MNZ9-1) [UniParc]FASTAAdd to Basket

    Also known as: WIPI-1 alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAEAADAPP GGVESALSCF SFNQDCTSLA TGTKAGYKLF SLSSVEQLDQ    50
    VHGSNEIPDV YIVERLFSSS LVVVVSHTKP RQMNVYHFKK GTEICNYSYS 100
    SNILSIRLNR QRLLVCLEES IYIHNIKDMK LLKTLLDIPA NPTGLCALSI 150
    NHSNSYLAYP GSLTSGEIVL YDGNSLKTVC TIAAHEGTLA AITFNASGSK 200
    LASASEKGTV IRVFSVPDGQ KLYEFRRGMK RYVTISSLVF SMDSQFLCAS 250
    SNTETVHIFK LEQVTNSRPE EPSTWSGYMG KMFMAATNYL PTQVSDMMHQ 300
    DRAFATARLN FSGQRNICTL STIQKLPRLL VASSSGHLYM YNLDPQDGGE 350
    CVLIKTHSLL GSGTTEENKE NDLRPSLPQS YAATVARPSA SSASTVPGYS 400
    EDGGALRGEV IPEHEFATGP VCLDDENEFP PIILCRGNQK GKTKQS 446
    Length:446
    Mass (Da):48,673
    Last modified:May 1, 2007 - v3
    Checksum:i35B5650990B62E31
    GO
    Isoform 2 (identifier: Q5MNZ9-2) [UniParc]FASTAAdd to Basket

    Also known as: WIPI-1 beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MEAEAA → M

    Show »
    Length:441
    Mass (Da):48,202
    Checksum:i969C220C162DC7F6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631V → A in AAV80760. (PubMed:15602573)Curated
    Sequence conflicti249 – 2491A → AA in AAV80760. (PubMed:15602573)Curated
    Sequence conflicti358 – 3581S → R in BAA91423. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311T → I.2 Publications
    Corresponds to variant rs883541 [ dbSNP | Ensembl ].
    VAR_024848
    Natural varianti308 – 3081R → H.
    Corresponds to variant rs36084378 [ dbSNP | Ensembl ].
    VAR_053439

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66MEAEAA → M in isoform 2. 1 PublicationVSP_016966

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY691424 mRNA. Translation: AAV80760.1.
    AK000917 mRNA. Translation: BAA91423.1.
    AC007780 Genomic DNA. No translation available.
    BC039867 mRNA. Translation: AAH39867.1.
    CCDSiCCDS11677.1. [Q5MNZ9-1]
    RefSeqiNP_060453.3. NM_017983.5. [Q5MNZ9-1]
    UniGeneiHs.463964.

    Genome annotation databases

    EnsembliENST00000262139; ENSP00000262139; ENSG00000070540. [Q5MNZ9-1]
    GeneIDi55062.
    KEGGihsa:55062.
    UCSCiuc010dey.3. human. [Q5MNZ9-1]

    Polymorphism databases

    DMDMi146291100.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY691424 mRNA. Translation: AAV80760.1 .
    AK000917 mRNA. Translation: BAA91423.1 .
    AC007780 Genomic DNA. No translation available.
    BC039867 mRNA. Translation: AAH39867.1 .
    CCDSi CCDS11677.1. [Q5MNZ9-1 ]
    RefSeqi NP_060453.3. NM_017983.5. [Q5MNZ9-1 ]
    UniGenei Hs.463964.

    3D structure databases

    ProteinModelPortali Q5MNZ9.
    SMRi Q5MNZ9. Positions 20-261, 316-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120380. 5 interactions.
    IntActi Q5MNZ9. 7 interactions.
    MINTi MINT-1392030.
    STRINGi 9606.ENSP00000262139.

    PTM databases

    PhosphoSitei Q5MNZ9.

    Polymorphism databases

    DMDMi 146291100.

    Proteomic databases

    MaxQBi Q5MNZ9.
    PaxDbi Q5MNZ9.
    PRIDEi Q5MNZ9.

    Protocols and materials databases

    DNASUi 55062.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262139 ; ENSP00000262139 ; ENSG00000070540 . [Q5MNZ9-1 ]
    GeneIDi 55062.
    KEGGi hsa:55062.
    UCSCi uc010dey.3. human. [Q5MNZ9-1 ]

    Organism-specific databases

    CTDi 55062.
    GeneCardsi GC17M066417.
    H-InvDB HIX0014115.
    HGNCi HGNC:25471. WIPI1.
    HPAi CAB037230.
    HPA007493.
    MIMi 609224. gene.
    neXtProti NX_Q5MNZ9.
    PharmGKBi PA142670575.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317564.
    HOGENOMi HOG000217544.
    HOVERGENi HBG056639.
    InParanoidi Q5MNZ9.
    KOi K17908.
    OMAi ILCRGSQ.
    PhylomeDBi Q5MNZ9.
    TreeFami TF314879.

    Enzyme and pathway databases

    Reactomei REACT_18273. XBP1(S) activates chaperone genes.
    SignaLinki Q5MNZ9.

    Miscellaneous databases

    ChiTaRSi WIPI1. human.
    GeneWikii WIPI1.
    GenomeRNAii 55062.
    NextBioi 58557.
    PROi Q5MNZ9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5MNZ9.
    Bgeei Q5MNZ9.
    CleanExi HS_WIPI1.
    Genevestigatori Q5MNZ9.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."
      Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A.
      Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AR; ESR1 AND ESR2, SUBCELLULAR LOCATION, VARIANT ILE-31.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-31.
      Tissue: Skin.
    5. "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49."
      Jeffries T.R., Dove S.K., Michell R.H., Parker P.J.
      Mol. Biol. Cell 15:2652-2663(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, BINDING TO PHOSPHOINOSITIDES, MUTAGENESIS OF 226-ARG-ARG-227.
    6. "Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy."
      Proikas-Cezanne T., Ruckerbauer S., Stierhof Y.D., Berg C., Nordheim A.
      FEBS Lett. 581:3396-3404(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy."
      Vergne I., Roberts E., Elmaoued R.A., Tosch V., Delgado M.A., Proikas-Cezanne T., Laporte J., Deretic V.
      EMBO J. 28:2244-2258(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins."
      Itakura E., Mizushima N.
      Autophagy 6:764-776(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. "Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation."
      Geeraert C., Ratier A., Pfisterer S.G., Perdiz D., Cantaloube I., Rouault A., Pattingre S., Proikas-Cezanne T., Codogno P., Pous C.
      J. Biol. Chem. 285:24184-24194(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MICROTUBULE-BINDING.
    11. "The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells."
      Gao P., Bauvy C., Souquere S., Tonelli G., Liu L., Zhu Y., Qiao Z., Bakula D., Proikas-Cezanne T., Pierron G., Codogno P., Chen Q., Mehrpour M.
      J. Biol. Chem. 285:25570-25581(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. "Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy."
      Taguchi-Atarashi N., Hamasaki M., Matsunaga K., Omori H., Ktistakis N.T., Yoshimori T., Noda T.
      Traffic 11:468-478(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    13. "WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition."
      Ho H., Kapadia R., Al-Tahan S., Ahmad S., Ganesan A.K.
      J. Biol. Chem. 286:12509-12523(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes."
      Proikas-Cezanne T., Robenek H.
      J. Cell. Mol. Med. 15:2007-2010(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    15. "Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy."
      Pfisterer S.G., Mauthe M., Codogno P., Proikas-Cezanne T.
      Mol. Pharmacol. 80:1066-1075(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REGULATION BY CALCIUM-SIGNALING, SUBCELLULAR LOCATION.
    16. "WIPI-1 positive autophagosome-like vesicles entrap pathogenic Staphylococcus aureus for lysosomal degradation."
      Mauthe M., Yu W., Krut O., Kronke M., Gotz F., Robenek H., Proikas-Cezanne T.
      Int. J. Cell Biol. 2012:179207-179207(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 beta-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition."
      Gaugel A., Bakula D., Hoffmann A., Proikas-Cezanne T.
      J. Mol. Signal. 7:16-16(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN, PIP2-BINDING, MUTAGENESIS OF SER-203; SER-205; GLY-208; THR-209; ARG-212; ARG-226; ARG-227; GLY-228; SER-251; THR-255 AND HIS-257.

    Entry informationi

    Entry nameiWIPI1_HUMAN
    AccessioniPrimary (citable) accession number: Q5MNZ9
    Secondary accession number(s): Q8IXM5, Q9NWF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3