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Q5MNZ9 (WIPI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat domain phosphoinositide-interacting protein 1

Short name=WIPI-1
Alternative name(s):
Atg18 protein homolog
WD40 repeat protein interacting with phosphoinositides of 49 kDa
Short name=WIPI 49 kDa
Gene names
Name:WIPI1
Synonyms:WIPI49
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Ref.1 Ref.5 Ref.8 Ref.9 Ref.10 Ref.13 Ref.16 Ref.17

Subunit structure

Interacts with androgen receptor (AR) and the estrogen receptors ESR1 and ESR2. Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. Ref.1

Subcellular location

Golgi apparatustrans-Golgi network. Endosome. Cytoplasmic vesicleclathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasmcytoskeleton. Note: Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules. Ref.1 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15

Tissue specificity

Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues. Ref.1

Domain

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P). Ref.17

Sequence similarities

Belongs to the WD repeat SVP1 family.

Contains 3 WD repeats.

Ontologies

Keywords
   Biological processAutophagy
   Cellular componentCytoplasm
Cytoplasmic vesicle
Cytoskeleton
Endosome
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of signaling protein activity involved in unfolded protein response

Traceable author statement. Source: Reactome

autophagic vacuole assembly

Inferred from Biological aspect of Ancestor. Source: RefGenome

autophagy

Inferred from expression pattern Ref.1Ref.6. Source: UniProtKB

cellular protein metabolic process

Traceable author statement. Source: Reactome

endoplasmic reticulum unfolded protein response

Traceable author statement. Source: Reactome

vesicle targeting, trans-Golgi to endosome

Inferred from direct assay Ref.5. Source: UniProtKB

   Cellular_componentGolgi membrane

Traceable author statement. Source: Reactome

autophagic vacuole membrane

Inferred from direct assay Ref.6. Source: UniProtKB

clathrin-coated vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from direct assay Ref.6. Source: UniProtKB

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Inferred from Biological aspect of Ancestor. Source: RefGenome

endosome membrane

Inferred from direct assay Ref.5. Source: UniProtKB

pre-autophagosomal structure

Inferred from direct assay Ref.1. Source: MGI

pre-autophagosomal structure membrane

Inferred from direct assay Ref.6. Source: UniProtKB

trans-Golgi network

Inferred from direct assay Ref.5. Source: UniProtKB

   Molecular_functionandrogen receptor binding

Inferred from direct assay Ref.1. Source: UniProtKB

estrogen receptor binding

Inferred from direct assay Ref.1. Source: UniProtKB

phosphatidylinositol-3,5-bisphosphate binding

Inferred from direct assay PubMed 20505359. Source: UniProtKB

phosphatidylinositol-3-phosphate binding

Inferred from direct assay Ref.5PubMed 20505359. Source: UniProtKB

receptor binding

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5MNZ9-1)

Also known as: WIPI-1 alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5MNZ9-2)

Also known as: WIPI-1 beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MEAEAA → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446WD repeat domain phosphoinositide-interacting protein 1
PRO_0000051437

Regions

Repeat184 – 22441WD 1
Repeat230 – 26940WD 2
Repeat312 – 35140WD 3
Motif131 – 1366Nuclear receptor interaction

Natural variations

Alternative sequence1 – 66MEAEAA → M in isoform 2.
VSP_016966
Natural variant311T → I. Ref.1 Ref.4
Corresponds to variant rs883541 [ dbSNP | Ensembl ].
VAR_024848
Natural variant3081R → H.
Corresponds to variant rs36084378 [ dbSNP | Ensembl ].
VAR_053439

Experimental info

Mutagenesis2031S → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2051S → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2081G → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2091T → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2121R → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis226 – 2272RR → AA: Loss of binding to phosphoinositides, does not disrupt the MPR pathway. Ref.5 Ref.17
Mutagenesis2261R → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2271R → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2281G → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2511S → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2551T → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Mutagenesis2571H → A: Loss of binding to phosphoinositides and abolishes puncta formation. Ref.5 Ref.17
Sequence conflict631V → A in AAV80760. Ref.1
Sequence conflict2491A → AA in AAV80760. Ref.1
Sequence conflict3581S → R in BAA91423. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (WIPI-1 alpha) [UniParc].

Last modified May 1, 2007. Version 3.
Checksum: 35B5650990B62E31

FASTA44648,673
        10         20         30         40         50         60 
MEAEAADAPP GGVESALSCF SFNQDCTSLA TGTKAGYKLF SLSSVEQLDQ VHGSNEIPDV 

        70         80         90        100        110        120 
YIVERLFSSS LVVVVSHTKP RQMNVYHFKK GTEICNYSYS SNILSIRLNR QRLLVCLEES 

       130        140        150        160        170        180 
IYIHNIKDMK LLKTLLDIPA NPTGLCALSI NHSNSYLAYP GSLTSGEIVL YDGNSLKTVC 

       190        200        210        220        230        240 
TIAAHEGTLA AITFNASGSK LASASEKGTV IRVFSVPDGQ KLYEFRRGMK RYVTISSLVF 

       250        260        270        280        290        300 
SMDSQFLCAS SNTETVHIFK LEQVTNSRPE EPSTWSGYMG KMFMAATNYL PTQVSDMMHQ 

       310        320        330        340        350        360 
DRAFATARLN FSGQRNICTL STIQKLPRLL VASSSGHLYM YNLDPQDGGE CVLIKTHSLL 

       370        380        390        400        410        420 
GSGTTEENKE NDLRPSLPQS YAATVARPSA SSASTVPGYS EDGGALRGEV IPEHEFATGP 

       430        440 
VCLDDENEFP PIILCRGNQK GKTKQS 

« Hide

Isoform 2 (WIPI-1 beta) [UniParc].

Checksum: 969C220C162DC7F6
Show »

FASTA44148,202

References

« Hide 'large scale' references
[1]"WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."
Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A.
Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AR; ESR1 AND ESR2, SUBCELLULAR LOCATION, VARIANT ILE-31.
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryo.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-31.
Tissue: Skin.
[5]"PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49."
Jeffries T.R., Dove S.K., Michell R.H., Parker P.J.
Mol. Biol. Cell 15:2652-2663(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, BINDING TO PHOSPHOINOSITIDES, MUTAGENESIS OF 226-ARG-ARG-227.
[6]"Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy."
Proikas-Cezanne T., Ruckerbauer S., Stierhof Y.D., Berg C., Nordheim A.
FEBS Lett. 581:3396-3404(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy."
Vergne I., Roberts E., Elmaoued R.A., Tosch V., Delgado M.A., Proikas-Cezanne T., Laporte J., Deretic V.
EMBO J. 28:2244-2258(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins."
Itakura E., Mizushima N.
Autophagy 6:764-776(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[9]"AMPK-independent induction of autophagy by cytosolic Ca2+ increase."
Grotemeier A., Alers S., Pfisterer S.G., Paasch F., Daubrawa M., Dieterle A., Viollet B., Wesselborg S., Proikas-Cezanne T., Stork B.
Cell. Signal. 22:914-925(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[10]"Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation."
Geeraert C., Ratier A., Pfisterer S.G., Perdiz D., Cantaloube I., Rouault A., Pattingre S., Proikas-Cezanne T., Codogno P., Pous C.
J. Biol. Chem. 285:24184-24194(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, MICROTUBULE-BINDING.
[11]"The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells."
Gao P., Bauvy C., Souquere S., Tonelli G., Liu L., Zhu Y., Qiao Z., Bakula D., Proikas-Cezanne T., Pierron G., Codogno P., Chen Q., Mehrpour M.
J. Biol. Chem. 285:25570-25581(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[12]"Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy."
Taguchi-Atarashi N., Hamasaki M., Matsunaga K., Omori H., Ktistakis N.T., Yoshimori T., Noda T.
Traffic 11:468-478(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[13]"WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition."
Ho H., Kapadia R., Al-Tahan S., Ahmad S., Ganesan A.K.
J. Biol. Chem. 286:12509-12523(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes."
Proikas-Cezanne T., Robenek H.
J. Cell. Mol. Med. 15:2007-2010(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[15]"Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy."
Pfisterer S.G., Mauthe M., Codogno P., Proikas-Cezanne T.
Mol. Pharmacol. 80:1066-1075(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REGULATION BY CALCIUM-SIGNALING, SUBCELLULAR LOCATION.
[16]"WIPI-1 positive autophagosome-like vesicles entrap pathogenic Staphylococcus aureus for lysosomal degradation."
Mauthe M., Yu W., Krut O., Kronke M., Gotz F., Robenek H., Proikas-Cezanne T.
Int. J. Cell Biol. 2012:179207-179207(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[17]"Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 beta-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition."
Gaugel A., Bakula D., Hoffmann A., Proikas-Cezanne T.
J. Mol. Signal. 7:16-16(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DOMAIN, PIP2-BINDING, MUTAGENESIS OF SER-203; SER-205; GLY-208; THR-209; ARG-212; ARG-226; ARG-227; GLY-228; SER-251; THR-255 AND HIS-257.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY691424 mRNA. Translation: AAV80760.1.
AK000917 mRNA. Translation: BAA91423.1.
AC007780 Genomic DNA. No translation available.
BC039867 mRNA. Translation: AAH39867.1.
CCDSCCDS11677.1. [Q5MNZ9-1]
RefSeqNP_060453.3. NM_017983.5. [Q5MNZ9-1]
UniGeneHs.463964.

3D structure databases

ProteinModelPortalQ5MNZ9.
SMRQ5MNZ9. Positions 20-261, 316-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120380. 5 interactions.
IntActQ5MNZ9. 7 interactions.
MINTMINT-1392030.
STRING9606.ENSP00000262139.

PTM databases

PhosphoSiteQ5MNZ9.

Polymorphism databases

DMDM146291100.

Proteomic databases

MaxQBQ5MNZ9.
PaxDbQ5MNZ9.
PRIDEQ5MNZ9.

Protocols and materials databases

DNASU55062.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262139; ENSP00000262139; ENSG00000070540. [Q5MNZ9-1]
GeneID55062.
KEGGhsa:55062.
UCSCuc010dey.3. human. [Q5MNZ9-1]

Organism-specific databases

CTD55062.
GeneCardsGC17M066417.
H-InvDBHIX0014115.
HGNCHGNC:25471. WIPI1.
HPACAB037230.
HPA007493.
MIM609224. gene.
neXtProtNX_Q5MNZ9.
PharmGKBPA142670575.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317564.
HOGENOMHOG000217544.
HOVERGENHBG056639.
InParanoidQ5MNZ9.
KOK17908.
OMAILCRGSQ.
PhylomeDBQ5MNZ9.
TreeFamTF314879.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.
SignaLinkQ5MNZ9.

Gene expression databases

ArrayExpressQ5MNZ9.
BgeeQ5MNZ9.
CleanExHS_WIPI1.
GenevestigatorQ5MNZ9.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
ProtoNetSearch...

Other

ChiTaRSWIPI1. human.
GeneWikiWIPI1.
GenomeRNAi55062.
NextBio58557.
PROQ5MNZ9.
SOURCESearch...

Entry information

Entry nameWIPI1_HUMAN
AccessionPrimary (citable) accession number: Q5MNZ9
Secondary accession number(s): Q8IXM5, Q9NWF8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM