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Protein

WD repeat domain phosphoinositide-interacting protein 3

Gene

WDR45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-1632852. Macroautophagy.
SignaLinkiQ5MNZ6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain phosphoinositide-interacting protein 3
Short name:
WIPI-3
Alternative name(s):
WD repeat-containing protein 45-like
Short name:
WDR45-like protein
WD repeat-containing protein 45B
WIPI49-like protein
Gene namesi
Name:WDR45B
Synonyms:WDR45L, WIPI3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25072. WDR45B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894387.

Polymorphism and mutation databases

BioMutaiWDR45B.
DMDMi85542094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344WD repeat domain phosphoinositide-interacting protein 3PRO_0000051445Add
BLAST

Proteomic databases

EPDiQ5MNZ6.
MaxQBiQ5MNZ6.
PaxDbiQ5MNZ6.
PRIDEiQ5MNZ6.

PTM databases

iPTMnetiQ5MNZ6.
PhosphoSiteiQ5MNZ6.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers.1 Publication

Gene expression databases

BgeeiQ5MNZ6.
CleanExiHS_WDR45L.
ExpressionAtlasiQ5MNZ6. baseline and differential.
GenevisibleiQ5MNZ6. HS.

Organism-specific databases

HPAiHPA017886.

Interactioni

Protein-protein interaction databases

BioGridi121130. 26 interactions.
IntActiQ5MNZ6. 3 interactions.
STRINGi9606.ENSP00000376139.

Structurei

3D structure databases

ProteinModelPortaliQ5MNZ6.
SMRiQ5MNZ6. Positions 18-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3837WD 1Add
BLAST
Repeati44 – 8744WD 2Add
BLAST
Repeati93 – 12533WD 3Add
BLAST
Repeati130 – 17142WD 4Add
BLAST
Repeati176 – 21540WD 5Add
BLAST
Repeati220 – 25940WD 6Add
BLAST
Repeati265 – 31450WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
ENOG410XQZ6. LUCA.
GeneTreeiENSGT00730000110940.
HOGENOMiHOG000217543.
HOVERGENiHBG053275.
InParanoidiQ5MNZ6.
OMAiNPKGECS.
OrthoDBiEOG76739Z.
PhylomeDBiQ5MNZ6.
TreeFamiTF314859.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5MNZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL
60 70 80 90 100
EGGVGHVEML FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST
110 120 130 140 150
EVKAVKLRRD RIVVVLDSMI KVFTFTHNPH QLHVFETCYN PKGLCVLCPN
160 170 180 190 200
SNNSLLAFPG THTGHVQLVD LASTEKPPVD IPAHEGVLSC IALNLQGTRI
210 220 230 240 250
ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINFNQ DASLICVSSD
260 270 280 290 300
HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA
310 320 330 340
FGTEPNAVIA ICADGSYYKF LFNPKGECIR DVYAQFLEMT DDKL
Length:344
Mass (Da):38,122
Last modified:January 10, 2006 - v2
Checksum:iCC60535E1D28660C
GO

Sequence cautioni

The sequence AAC72952.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 572HV → TR in AAC72952 (Ref. 3) Curated
Sequence conflicti69 – 691V → A in CAG33051 (Ref. 5) Curated
Sequence conflicti254 – 2541V → A in AAV80763 (PubMed:15602573).Curated
Sequence conflicti339 – 3391M → L in AAV80763 (PubMed:15602573).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM182326 mRNA. Translation: CAJ57996.1.
CH471099 Genomic DNA. Translation: EAW89810.1.
AF091083 mRNA. Translation: AAC72952.1. Different initiation.
AY691427 mRNA. Translation: AAV80763.1.
CR456770 mRNA. Translation: CAG33051.1.
CCDSiCCDS11815.2.
RefSeqiNP_062559.2. NM_019613.3.
UniGeneiHs.132161.

Genome annotation databases

EnsembliENST00000392325; ENSP00000376139; ENSG00000141580.
GeneIDi56270.
KEGGihsa:56270.
UCSCiuc002kfq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM182326 mRNA. Translation: CAJ57996.1.
CH471099 Genomic DNA. Translation: EAW89810.1.
AF091083 mRNA. Translation: AAC72952.1. Different initiation.
AY691427 mRNA. Translation: AAV80763.1.
CR456770 mRNA. Translation: CAG33051.1.
CCDSiCCDS11815.2.
RefSeqiNP_062559.2. NM_019613.3.
UniGeneiHs.132161.

3D structure databases

ProteinModelPortaliQ5MNZ6.
SMRiQ5MNZ6. Positions 18-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121130. 26 interactions.
IntActiQ5MNZ6. 3 interactions.
STRINGi9606.ENSP00000376139.

PTM databases

iPTMnetiQ5MNZ6.
PhosphoSiteiQ5MNZ6.

Polymorphism and mutation databases

BioMutaiWDR45B.
DMDMi85542094.

Proteomic databases

EPDiQ5MNZ6.
MaxQBiQ5MNZ6.
PaxDbiQ5MNZ6.
PRIDEiQ5MNZ6.

Protocols and materials databases

DNASUi56270.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392325; ENSP00000376139; ENSG00000141580.
GeneIDi56270.
KEGGihsa:56270.
UCSCiuc002kfq.3. human.

Organism-specific databases

CTDi56270.
GeneCardsiWDR45B.
HGNCiHGNC:25072. WDR45B.
HPAiHPA017886.
MIMi609226. gene.
neXtProtiNX_Q5MNZ6.
PharmGKBiPA134894387.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
ENOG410XQZ6. LUCA.
GeneTreeiENSGT00730000110940.
HOGENOMiHOG000217543.
HOVERGENiHBG053275.
InParanoidiQ5MNZ6.
OMAiNPKGECS.
OrthoDBiEOG76739Z.
PhylomeDBiQ5MNZ6.
TreeFamiTF314859.

Enzyme and pathway databases

ReactomeiR-HSA-1632852. Macroautophagy.
SignaLinkiQ5MNZ6.

Miscellaneous databases

GeneWikiiWDR45L.
GenomeRNAii56270.
NextBioi61941.
PROiQ5MNZ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ5MNZ6.
CleanExiHS_WDR45L.
ExpressionAtlasiQ5MNZ6. baseline and differential.
GenevisibleiQ5MNZ6. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of human WIPI-3 in silico."
    Wang H., Ma X., Zhang Y., Wu C.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Full-insert sequence of mapped XREF EST."
    Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-344.
  4. "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."
    Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A.
    Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-344, TISSUE SPECIFICITY.
    Tissue: Testis.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-344.

Entry informationi

Entry nameiWIPI3_HUMAN
AccessioniPrimary (citable) accession number: Q5MNZ6
Secondary accession number(s): O95328, Q2MCP6, Q6IBN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: March 16, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.