Q5MNZ6 (WIPI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat domain phosphoinositide-interacting protein 3
Short name=WIPI-3

Alternative name(s):
WD repeat-containing protein 45-like
Short name=WDR45-like protein
WIPI49-like protein

Gene names

Name:	WDR45L
Synonyms:	WIPI3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. Ref.4
Sequence similarities	Belongs to the WD repeat SVP1 family. Contains 2 WD repeats.
Sequence caution	The sequence AAC72952.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from Biological aspect of Ancestor. Source: RefGenome response to starvation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	organelle membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	phosphatidylinositol-3,5-bisphosphate binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	WD repeat domain phosphoinositide-interacting protein 3		PRO_0000051445
Regions
	Repeat	183 – 223	41	WD 1
	Repeat	228 – 267	40	WD 2
Experimental info
	Sequence conflict	56 – 57	2	HV → TR in AAC72952. Ref.3
	Sequence conflict	69	1	V → A in CAG33051. Ref.5
	Sequence conflict	254	1	V → A in AAV80763. Ref.4
	Sequence conflict	339	1	M → L in AAV80763. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q5MNZ6 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: CC60535E1D28660C	FASTA	344	38,122
	10 20 30 40 50 60 MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL EGGVGHVEML 70 80 90 100 110 120 FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST EVKAVKLRRD RIVVVLDSMI 130 140 150 160 170 180 KVFTFTHNPH QLHVFETCYN PKGLCVLCPN SNNSLLAFPG THTGHVQLVD LASTEKPPVD 190 200 210 220 230 240 IPAHEGVLSC IALNLQGTRI ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINFNQ 250 260 270 280 290 300 DASLICVSSD HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA 310 320 330 340 FGTEPNAVIA ICADGSYYKF LFNPKGECIR DVYAQFLEMT DDKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of human WIPI-3 in silico." Wang H., Ma X., Zhang Y., Wu C. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Full-insert sequence of mapped XREF EST." Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-344.
[4]	"WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A. Oncogene 23:9314-9325(2004) [PubMed: 15602573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-344, TISSUE SPECIFICITY. Tissue: Testis.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-344.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM182326 mRNA. Translation: CAJ57996.1. CH471099 Genomic DNA. Translation: EAW89810.1. AF091083 mRNA. Translation: AAC72952.1. Different initiation. AY691427 mRNA. Translation: AAV80763.1. CR456770 mRNA. Translation: CAG33051.1.
IPI	IPI00021329.
RefSeq	NP_062559.2. NM_019613.3.
UniGene	Hs.132161.
3D structure databases
ProteinModelPortal	Q5MNZ6.
SMR	Q5MNZ6. Positions 317-343.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5MNZ6. 2 interactions.
Polymorphism databases
DMDM	85542094.
Proteomic databases
PRIDE	Q5MNZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000392325; ENSP00000376139; ENSG00000141580.
GeneID	56270.
KEGG	hsa:56270.
UCSC	uc002kfq.1. human.
Organism-specific databases
CTD	56270.
GeneCards	GC17M080573.
H-InvDB	HIX0014276.
HGNC	HGNC:25072. WDR45L.
HPA	HPA017886.
MIM	609226. gene.
neXtProt	NX_Q5MNZ6.
PharmGKB	PA134894387.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17716.
GeneTree	ENSGT00530000062939.
HOGENOM	HBG443829.
HOVERGEN	HBG053275.
InParanoid	Q5MNZ6.
OMA	NQKGECS.
OrthoDB	EOG4229K1.
PhylomeDB	Q5MNZ6.
Gene expression databases
ArrayExpress	Q5MNZ6.
Bgee	Q5MNZ6.
CleanEx	HS_WDR45L.
Genevestigator	Q5MNZ6.
GermOnline	ENSG00000141580. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 2 hits. [Graphical view]
SMART	SM00320. WD40. 2 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	61941.
SOURCE	Search...

Entry information

Entry name

WIPI3_HUMAN

Accession

Primary (citable) accession number: Q5MNZ6
Secondary accession number(s): O95328, Q2MCP6, Q6IBN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	January 25, 2012
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.