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Protein

Interleukin-2 receptor subunit alpha

Gene

IL2RA

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
CD_antigen: CD25
Gene namesi
Name:IL2RA
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 240219ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 25919HelicalSequence analysisAdd
BLAST
Topological domaini260 – 27213CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 272251Interleukin-2 receptor subunit alphaPRO_0000011025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 67PROSITE-ProRule annotation
Disulfide bondi49 ↔ 80PROSITE-ProRule annotation
Disulfide bondi51 ↔ 82PROSITE-ProRule annotation
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi125 ↔ 168PROSITE-ProRule annotation
Disulfide bondi152 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000036344.

Structurei

3D structure databases

ProteinModelPortaliQ5MNY4.
SMRiQ5MNY4. Positions 22-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 8463Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini123 – 18664Sushi 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.
InParanoidiQ5MNY4.
KOiK05068.

Family and domain databases

InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5MNY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPYLLMWGL LTFITVPGCQ AELCDDDPPK ITHATFKAVA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSPYMLCTGN SSHSSWDNQC QCTSSAARNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SQMQLADQVS LPGHCREPPP WENEATERIY HFVVGQMVYY
160 170 180 190 200
QCVQGYRALH RGPAESICKM THGKTRWTQP QLICTGETEP SQFPGEEEPQ
210 220 230 240 250
ASPDGLPESE TSRLVTTTDF RIQTEVAATM ETFIFTTEYQ VAVAGCVFLL
260 270
ISVLLLSGLT WQRRQRKNRR TI
Length:272
Mass (Da):30,831
Last modified:February 1, 2005 - v1
Checksum:i553E9397033E61B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY693777 mRNA. Translation: AAV49318.1.
RefSeqiNP_001028089.1. NM_001032917.2.
UniGeneiMmu.3810.

Genome annotation databases

GeneIDi574300.
KEGGimcc:574300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY693777 mRNA. Translation: AAV49318.1.
RefSeqiNP_001028089.1. NM_001032917.2.
UniGeneiMmu.3810.

3D structure databases

ProteinModelPortaliQ5MNY4.
SMRiQ5MNY4. Positions 22-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000036344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574300.
KEGGimcc:574300.

Organism-specific databases

CTDi3559.

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.
InParanoidiQ5MNY4.
KOiK05068.

Family and domain databases

InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA."
    Silvertown J.D., Walia J.S., Medin J.A.
    Dev. Comp. Immunol. 29:989-1002(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL2RA_MACMU
AccessioniPrimary (citable) accession number: Q5MNY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.