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Protein

F-box only protein 47

Gene

FBXO47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 47
Gene namesi
Name:FBXO47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:31969. FBXO47.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388157.

Polymorphism and mutation databases

BioMutaiFBXO47.
DMDMi296434512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452F-box only protein 47PRO_0000119952Add
BLAST

Proteomic databases

EPDiQ5MNV8.
PaxDbiQ5MNV8.
PRIDEiQ5MNV8.

PTM databases

iPTMnetiQ5MNV8.
PhosphoSiteiQ5MNV8.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.1 Publication

Gene expression databases

BgeeiQ5MNV8.
CleanExiHS_FBXO47.

Organism-specific databases

HPAiHPA057438.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000367319.

Structurei

3D structure databases

ProteinModelPortaliQ5MNV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 9151F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIZ0. Eukaryota.
ENOG410Z5JV. LUCA.
GeneTreeiENSGT00390000014175.
HOGENOMiHOG000261636.
HOVERGENiHBG051584.
InParanoidiQ5MNV8.
KOiK10321.
OMAiMEMLQSI.
OrthoDBiEOG7M98GB.
PhylomeDBiQ5MNV8.
TreeFamiTF343134.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5MNV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRINTNFT LIPNQKLRRS NRQTSCYSKT LGSGFQPIST FGNFKALPLE
60 70 80 90 100
IFQIILKYLS VKDISMLSMV SKTVSQHIIN YISTSSGSKR LLLQDFHNLE
110 120 130 140 150
LPDRRQDSAI LEHYRSLGLL FKRCTLLLPT KERLKYIHKI LTEVSCFKFN
160 170 180 190 200
GCAAPMQCLG LTCYGMFLQT LTAGWDELEC HRVYNFLCEL TNLCRKIQMA
210 220 230 240 250
VCSKPGSAQK LELRIRLFCR NVLLDHWTHR SDSAFWLTRI LKPWPMVNQA
260 270 280 290 300
RLLYIIFGPI SPQDGQVVWQ EMIEEPTDEF SLKGLADAIK LLYDASTKEW
310 320 330 340 350
TADDVISLVD ELSVVPREWL LENNARLLML SGNNICFSFM ASKAVNGRTI
360 370 380 390 400
ELARLVVFLA LVCEKELYCM DWTVKMMQKV CKVFSTPVER KNFLQNVANA
410 420 430 440 450
FACVIMEMLQ SIMSGDRDED DRSFLNLFHL VHAQANFHKE VLYLTMNTPL

ST
Length:452
Mass (Da):51,968
Last modified:May 18, 2010 - v2
Checksum:i703CBF21CAF67FB9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti209 – 2091Q → R.2 Publications
Corresponds to variant rs9906595 [ dbSNP | Ensembl ].
VAR_049052

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY700575 mRNA. Translation: AAV91324.1.
AC006441 Genomic DNA. No translation available.
BC140879 mRNA. Translation: AAI40880.1.
BC140880 mRNA. Translation: AAI40881.1.
CCDSiCCDS32639.1.
RefSeqiNP_001008777.2. NM_001008777.2.
XP_011523166.1. XM_011524864.1.
UniGeneiHs.549536.

Genome annotation databases

EnsembliENST00000378079; ENSP00000367319; ENSG00000204952.
GeneIDi494188.
KEGGihsa:494188.
UCSCiuc002hrc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY700575 mRNA. Translation: AAV91324.1.
AC006441 Genomic DNA. No translation available.
BC140879 mRNA. Translation: AAI40880.1.
BC140880 mRNA. Translation: AAI40881.1.
CCDSiCCDS32639.1.
RefSeqiNP_001008777.2. NM_001008777.2.
XP_011523166.1. XM_011524864.1.
UniGeneiHs.549536.

3D structure databases

ProteinModelPortaliQ5MNV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367319.

PTM databases

iPTMnetiQ5MNV8.
PhosphoSiteiQ5MNV8.

Polymorphism and mutation databases

BioMutaiFBXO47.
DMDMi296434512.

Proteomic databases

EPDiQ5MNV8.
PaxDbiQ5MNV8.
PRIDEiQ5MNV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378079; ENSP00000367319; ENSG00000204952.
GeneIDi494188.
KEGGihsa:494188.
UCSCiuc002hrc.2. human.

Organism-specific databases

CTDi494188.
GeneCardsiFBXO47.
H-InvDBHIX0039142.
HGNCiHGNC:31969. FBXO47.
HPAiHPA057438.
MIMi609498. gene.
neXtProtiNX_Q5MNV8.
PharmGKBiPA162388157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZ0. Eukaryota.
ENOG410Z5JV. LUCA.
GeneTreeiENSGT00390000014175.
HOGENOMiHOG000261636.
HOVERGENiHBG051584.
InParanoidiQ5MNV8.
KOiK10321.
OMAiMEMLQSI.
OrthoDBiEOG7M98GB.
PhylomeDBiQ5MNV8.
TreeFamiTF343134.

Miscellaneous databases

GenomeRNAii494188.
PROiQ5MNV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ5MNV8.
CleanExiHS_FBXO47.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma."
    Simon-Kayser B., Scoul C., Renaudin K., Jezequel P., Bouchot O., Rigaud J., Bezieau S.
    Genes Chromosomes Cancer 43:83-94(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ARG-209.
    Tissue: Testis.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-209.

Entry informationi

Entry nameiFBX47_HUMAN
AccessioniPrimary (citable) accession number: Q5MNV8
Secondary accession number(s): B2RTZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.