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Protein

F-box only protein 47

Gene

FBXO47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 47
Gene namesi
Name:FBXO47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000204952.2.
HGNCiHGNC:31969. FBXO47.

Pathology & Biotechi

Organism-specific databases

DisGeNETi494188.
OpenTargetsiENSG00000204952.
PharmGKBiPA162388157.

Polymorphism and mutation databases

BioMutaiFBXO47.
DMDMi296434512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199521 – 452F-box only protein 47Add BLAST452

Proteomic databases

PaxDbiQ5MNV8.
PeptideAtlasiQ5MNV8.
PRIDEiQ5MNV8.

PTM databases

iPTMnetiQ5MNV8.
PhosphoSitePlusiQ5MNV8.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.1 Publication

Gene expression databases

BgeeiENSG00000204952.
CleanExiHS_FBXO47.

Organism-specific databases

HPAiHPA057438.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000367319.

Structurei

3D structure databases

ProteinModelPortaliQ5MNV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 91F-boxPROSITE-ProRule annotationAdd BLAST51

Phylogenomic databases

eggNOGiENOG410IIZ0. Eukaryota.
ENOG410Z5JV. LUCA.
GeneTreeiENSGT00390000014175.
HOGENOMiHOG000261636.
HOVERGENiHBG051584.
InParanoidiQ5MNV8.
KOiK10321.
OMAiMEMLQSI.
OrthoDBiEOG091G0JXK.
PhylomeDBiQ5MNV8.
TreeFamiTF343134.

Family and domain databases

InterProiView protein in InterPro
IPR001810. F-box_dom.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5MNV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRINTNFT LIPNQKLRRS NRQTSCYSKT LGSGFQPIST FGNFKALPLE
60 70 80 90 100
IFQIILKYLS VKDISMLSMV SKTVSQHIIN YISTSSGSKR LLLQDFHNLE
110 120 130 140 150
LPDRRQDSAI LEHYRSLGLL FKRCTLLLPT KERLKYIHKI LTEVSCFKFN
160 170 180 190 200
GCAAPMQCLG LTCYGMFLQT LTAGWDELEC HRVYNFLCEL TNLCRKIQMA
210 220 230 240 250
VCSKPGSAQK LELRIRLFCR NVLLDHWTHR SDSAFWLTRI LKPWPMVNQA
260 270 280 290 300
RLLYIIFGPI SPQDGQVVWQ EMIEEPTDEF SLKGLADAIK LLYDASTKEW
310 320 330 340 350
TADDVISLVD ELSVVPREWL LENNARLLML SGNNICFSFM ASKAVNGRTI
360 370 380 390 400
ELARLVVFLA LVCEKELYCM DWTVKMMQKV CKVFSTPVER KNFLQNVANA
410 420 430 440 450
FACVIMEMLQ SIMSGDRDED DRSFLNLFHL VHAQANFHKE VLYLTMNTPL

ST
Length:452
Mass (Da):51,968
Last modified:May 18, 2010 - v2
Checksum:i703CBF21CAF67FB9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049052209Q → R2 PublicationsCorresponds to variant dbSNP:rs9906595Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY700575 mRNA. Translation: AAV91324.1.
AC006441 Genomic DNA. No translation available.
BC140879 mRNA. Translation: AAI40880.1.
BC140880 mRNA. Translation: AAI40881.1.
CCDSiCCDS32639.1.
RefSeqiNP_001008777.2. NM_001008777.2.
UniGeneiHs.549536.

Genome annotation databases

EnsembliENST00000378079; ENSP00000367319; ENSG00000204952.
GeneIDi494188.
KEGGihsa:494188.
UCSCiuc002hrc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFBX47_HUMAN
AccessioniPrimary (citable) accession number: Q5MNV8
Secondary accession number(s): B2RTZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot