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Q5MJS3

- DMP4_MOUSE

UniProt

Q5MJS3 - DMP4_MOUSE

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Protein
Extracellular serine/threonine protein kinase FAM20C
Gene
Fam20c, Dmp4, Kiaa4081
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-binding kinase that phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif By similarity.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi458 – 4581Manganese By similarity
Metal bindingi473 – 4731Manganese By similarity

GO - Molecular functioni

  1. calcium ion binding Source: MGI
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. dentinogenesis Source: MGI
  2. enamel mineralization Source: MGI
  3. odontoblast differentiation Source: MGI
  4. osteoclast maturation Source: MGI
  5. positive regulation of bone mineralization Source: MGI
  6. positive regulation of osteoblast differentiation Source: MGI
  7. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  8. regulation of phosphorus metabolic process Source: MGI
  9. skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular serine/threonine protein kinase FAM20C (EC:2.7.11.1)
Alternative name(s):
Dentin matrix protein 4
Short name:
DMP-4
Golgi-enriched fraction casein kinase
Short name:
GEF-CK
Gene namesi
Name:Fam20c
Synonyms:Dmp4, Kiaa4081
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2136853. Fam20c.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 579553Extracellular serine/threonine protein kinase FAM20C
PRO_0000297978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5MJS3.
PRIDEiQ5MJS3.

PTM databases

PhosphoSiteiQ5MJS3.

Expressioni

Tissue specificityi

Highly expressed in the tooth. No expression in the dental pulp. At the secretory stage of amelogenesis, it is detected in the matrix of the enamel, in the ameloblasts, and within the cells adjoining the stratum intermedium (a tissue layer analogous to the stellate reticulum seen in the developing molar). Strong expression is observed in maturation stage ameloblasts and throughout the non-cornified layers of the gingival epithelium. Expressed at moderate levels in bone and at low levels in kidney, liver, brain and lung. Very low expression, if any, in spleen and skeletal muscle.2 Publications

Developmental stagei

In the developing tooth, initial expression observed in odontoblasts at all stages of development. At later stages, restricted expression pattern in ameloblasts. Also observed in osteoblats in the alveolar bone.1 Publication

Gene expression databases

ArrayExpressiQ5MJS3.
BgeeiQ5MJS3.
GenevestigatoriQ5MJS3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026972.

Structurei

3D structure databases

ProteinModelPortaliQ5MJS3.
SMRiQ5MJS3. Positions 220-565.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni349 – 560212Kinase domain By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the FAM20 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG238678.
GeneTreeiENSGT00390000007484.
HOGENOMiHOG000231437.
HOVERGENiHBG051635.
InParanoidiQ5MJS3.
OMAiPDWPREG.
OrthoDBiEOG7JX33T.
PhylomeDBiQ5MJS3.
TreeFamiTF313276.

Family and domain databases

InterProiIPR009581. DUF1193.
IPR024869. FAM20.
[Graphical view]
PANTHERiPTHR12450. PTHR12450. 1 hit.
PfamiPF06702. DUF1193. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5MJS3-1 [UniParc]FASTAAdd to Basket

« Hide

MKMILVRRFR VLILVVFLLA CALHIAVDLL PKLDRRATRS SGEPGCSCAQ    50
PAAEAAGPGW AQARSRPGES AGGDAGWPNK HTLRILQDFS SDPASNLTSH 100
SLEKLPSAAE PVDHAPRGQE PRSPPPRDPA HRPLLRDPGP RPRVPPPGPS 150
GDGSLLAKLF EHPLYQGAVP PLTEDDVLFN VNSDIRFNPK AAENPDWPHE 200
GAEGAEFLPT GEAAVNLYPN WLKFHIGINR YELYSRHNPA IDALLRDLGS 250
QKITSVAMKS GGTQLKLIMT FQNYGQALFK PMKQTREQET PPDFFYFSDY 300
ERHNAEIAAF HLDRILDFRR VPPVAGRMIN MTKEIRDVTR DKKLWRTFFV 350
SPANNICFYG ECSYYCSTEH ALCGRPDQIE GSLAAFLPDL SLAKRKTWRN 400
PWRRSYHKRK KAEWEVDPDY CEEVKQTPPY DSGHRILDIM DMTVFDFLMG 450
NMDRHHYETF EKFGNETFII HLDNGRGFGK YSHDELSILA PLHQCCRIRR 500
STYLRLQLLA KEEHKLSLLM AESLQHDKVA PVLYQLHLEA LDRRLRIVLQ 550
AVRDCVEKDG LSSVVEDDLA TEHRASTER 579
Length:579
Mass (Da):65,766
Last modified:February 1, 2005 - v1
Checksum:i9DE5F5496AC117FE
GO

Sequence cautioni

The sequence AAH04044.3 differs from that shown. Reason: Frameshift at position 294.
The sequence BAD90211.1 differs from that shown. Reason: Frameshift at position 296.
The sequence AAH04044.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH25814.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH25826.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD90211.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti333 – 3331K → N in CAJ18570. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY778962 mRNA. Translation: AAV91326.1.
AK220286 mRNA. Translation: BAD90211.1. Sequence problems.
BC004044 mRNA. Translation: AAH04044.3. Sequence problems.
BC025814 mRNA. Translation: AAH25814.1. Different initiation.
BC025826 mRNA. Translation: AAH25826.1. Different initiation.
CT010363 mRNA. Translation: CAJ18570.1.
CCDSiCCDS51681.1.
RefSeqiNP_085042.2. NM_030565.6.
UniGeneiMm.320355.

Genome annotation databases

EnsembliENSMUST00000026972; ENSMUSP00000026972; ENSMUSG00000025854.
GeneIDi80752.
KEGGimmu:80752.
UCSCiuc009afv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY778962 mRNA. Translation: AAV91326.1 .
AK220286 mRNA. Translation: BAD90211.1 . Sequence problems.
BC004044 mRNA. Translation: AAH04044.3 . Sequence problems.
BC025814 mRNA. Translation: AAH25814.1 . Different initiation.
BC025826 mRNA. Translation: AAH25826.1 . Different initiation.
CT010363 mRNA. Translation: CAJ18570.1 .
CCDSi CCDS51681.1.
RefSeqi NP_085042.2. NM_030565.6.
UniGenei Mm.320355.

3D structure databases

ProteinModelPortali Q5MJS3.
SMRi Q5MJS3. Positions 220-565.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000026972.

PTM databases

PhosphoSitei Q5MJS3.

Proteomic databases

PaxDbi Q5MJS3.
PRIDEi Q5MJS3.

Protocols and materials databases

DNASUi 80752.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026972 ; ENSMUSP00000026972 ; ENSMUSG00000025854 .
GeneIDi 80752.
KEGGi mmu:80752.
UCSCi uc009afv.2. mouse.

Organism-specific databases

CTDi 56975.
MGIi MGI:2136853. Fam20c.
Rougei Search...

Phylogenomic databases

eggNOGi NOG238678.
GeneTreei ENSGT00390000007484.
HOGENOMi HOG000231437.
HOVERGENi HBG051635.
InParanoidi Q5MJS3.
OMAi PDWPREG.
OrthoDBi EOG7JX33T.
PhylomeDBi Q5MJS3.
TreeFami TF313276.

Miscellaneous databases

ChiTaRSi FAM20C. mouse.
NextBioi 350121.
PROi Q5MJS3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5MJS3.
Bgeei Q5MJS3.
Genevestigatori Q5MJS3.

Family and domain databases

InterProi IPR009581. DUF1193.
IPR024869. FAM20.
[Graphical view ]
PANTHERi PTHR12450. PTHR12450. 1 hit.
Pfami PF06702. DUF1193. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation."
    Hao J., Narayanan K., Muni T., Ramachandran A., George A.
    J. Biol. Chem. 282:15357-15365(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Seino S., Nishimura M., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreatic islet.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver and Mammary tumor.
  4. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-579.
  5. "Whole-exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfecta and gingival hyperplasia syndrome."
    O'Sullivan J., Bitu C.C., Daly S.B., Urquhart J.E., Barron M.J., Bhaskar S.S., Martelli-Junior H., dos Santos Neto P.E., Mansilla M.A., Murray J.C., Coletta R.D., Black G.C., Dixon M.J.
    Am. J. Hum. Genet. 88:616-620(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDMP4_MOUSE
AccessioniPrimary (citable) accession number: Q5MJS3
Secondary accession number(s): Q4FJP0
, Q571A3, Q6PKA8, Q8JZP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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