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Q5MJ70

- SPDYA_HUMAN

UniProt

Q5MJ70 - SPDYA_HUMAN

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Protein

Speedy protein A

Gene

SPDYA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2.3 Publications

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: UniProtKB
  2. G1/S transition of mitotic cell cycle Source: UniProtKB
  3. male meiosis Source: UniProtKB
  4. multicellular organismal development Source: UniProtKB-KW
  5. positive regulation of cell proliferation Source: UniProtKB
  6. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, DNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
Speedy protein A
Alternative name(s):
Rapid inducer of G2/M progression in oocytes A
Short name:
RINGO A
Short name:
hSpy/Ringo A
Speedy-1
Short name:
Spy1
Gene namesi
Name:SPDYAImported
Synonyms:SPDY1Imported, SPY1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30613. SPDYA.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Speedy protein APRO_0000234112Add
BLAST

Proteomic databases

PaxDbiQ5MJ70.
PRIDEiQ5MJ70.

PTM databases

PhosphoSiteiQ5MJ70.

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase.2 Publications

Gene expression databases

BgeeiQ5MJ70.
CleanExiHS_SPDYA.
ExpressionAtlasiQ5MJ70. baseline and differential.
GenevestigatoriQ5MJ70.

Interactioni

Subunit structurei

Interacts with CDK1, CDK2 and CDKN1B/KIP1. Found in a complex with both CDK2 and CDKN1B/KIP1.3 Publications

Protein-protein interaction databases

BioGridi128828. 5 interactions.
IntActiQ5MJ70. 2 interactions.
MINTiMINT-7226374.
STRINGi9606.ENSP00000335628.

Structurei

3D structure databases

ProteinModelPortaliQ5MJ70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 200133Speedy/Ringo box; Required for CDK-bindingBy similarityAdd
BLAST

Domaini

The C-terminus is required for CDK2-activation, but not CDK2-binding.By similarity

Sequence similaritiesi

Belongs to the Speedy/Ringo family.Curated

Phylogenomic databases

eggNOGiNOG42793.
GeneTreeiENSGT00420000029723.
HOGENOMiHOG000060281.
HOVERGENiHBG086798.
InParanoidiQ5MJ70.
KOiK08694.
OMAiKHSQESH.
OrthoDBiEOG7PS1FZ.
PhylomeDBiQ5MJ70.
TreeFamiTF329827.

Family and domain databases

InterProiIPR020984. Cell_cycle_regulatory_Spy1.
[Graphical view]
PfamiPF11357. Spy1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 22 Publications (identifier: Q5MJ70-2) [UniParc]FASTAAdd to Basket

Also known as: A21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRHNQMCCET PPTVTVYVKS GSNRSHQPKK PITLKRPICK DNWQAFEKNT
60 70 80 90 100
HNNNKSKRPK GPCLVIQRQD MTAFFKLFDD DLIQDFLWMD CCCKIADKYL
110 120 130 140 150
LAMTFVYFKR AKFTISEHTR INFFIALYLA NTVEEDEEET KYEIFPWALG
160 170 180 190 200
KNWRKLFPNF LKLRDQLWDR IDYRAIVSRR CCEEVMAIAP THYIWQRERS
210 220 230 240 250
VHHSGAVRNY NRDEVQLPRG PSATPVDCSL CGKKRRYVRL GLSSSSSLSS
260 270 280 290 300
HTAGVTEKHS QDSYNSLSMD IIGDPSQAYT GSEVVNDHQS NKGKKTNFLK
310
KDKSMEWFTG SEE
Length:313
Mass (Da):36,463
Last modified:May 2, 2006 - v2
Checksum:iF511EECB26245EEC
GO
Isoform 11 Publication (identifier: Q5MJ70-1) [UniParc]FASTAAdd to Basket

Also known as: A11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     284-286: VVN → GMI
     287-313: Missing.

Show »
Length:286
Mass (Da):33,269
Checksum:i348BAE62F09024E9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 2863VVN → GMI in isoform 1. 2 PublicationsVSP_052027
Alternative sequencei287 – 31327Missing in isoform 1. 2 PublicationsVSP_052028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY820303 mRNA. Translation: AAW30394.1.
AY820304 mRNA. Translation: AAW30395.1.
AC097720 Genomic DNA. Translation: AAY24014.1.
BC093005 mRNA. Translation: AAH93005.1.
CCDSiCCDS1767.2. [Q5MJ70-2]
RefSeqiNP_001008779.1. NM_001008779.1. [Q5MJ70-1]
NP_001136106.1. NM_001142634.1. [Q5MJ70-2]
NP_877433.2. NM_182756.3. [Q5MJ70-2]
UniGeneiHs.511956.

Genome annotation databases

EnsembliENST00000334056; ENSP00000335628; ENSG00000163806. [Q5MJ70-2]
ENST00000379579; ENSP00000368898; ENSG00000163806. [Q5MJ70-2]
GeneIDi245711.
KEGGihsa:245711.
UCSCiuc002rmi.3. human. [Q5MJ70-1]
uc002rmj.3. human. [Q5MJ70-2]

Polymorphism databases

DMDMi94730574.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY820303 mRNA. Translation: AAW30394.1 .
AY820304 mRNA. Translation: AAW30395.1 .
AC097720 Genomic DNA. Translation: AAY24014.1 .
BC093005 mRNA. Translation: AAH93005.1 .
CCDSi CCDS1767.2. [Q5MJ70-2 ]
RefSeqi NP_001008779.1. NM_001008779.1. [Q5MJ70-1 ]
NP_001136106.1. NM_001142634.1. [Q5MJ70-2 ]
NP_877433.2. NM_182756.3. [Q5MJ70-2 ]
UniGenei Hs.511956.

3D structure databases

ProteinModelPortali Q5MJ70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128828. 5 interactions.
IntActi Q5MJ70. 2 interactions.
MINTi MINT-7226374.
STRINGi 9606.ENSP00000335628.

PTM databases

PhosphoSitei Q5MJ70.

Polymorphism databases

DMDMi 94730574.

Proteomic databases

PaxDbi Q5MJ70.
PRIDEi Q5MJ70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334056 ; ENSP00000335628 ; ENSG00000163806 . [Q5MJ70-2 ]
ENST00000379579 ; ENSP00000368898 ; ENSG00000163806 . [Q5MJ70-2 ]
GeneIDi 245711.
KEGGi hsa:245711.
UCSCi uc002rmi.3. human. [Q5MJ70-1 ]
uc002rmj.3. human. [Q5MJ70-2 ]

Organism-specific databases

CTDi 245711.
GeneCardsi GC02P029007.
H-InvDB HIX0021816.
HGNCi HGNC:30613. SPDYA.
MIMi 614029. gene.
neXtProti NX_Q5MJ70.
PharmGKBi PA134954857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42793.
GeneTreei ENSGT00420000029723.
HOGENOMi HOG000060281.
HOVERGENi HBG086798.
InParanoidi Q5MJ70.
KOi K08694.
OMAi KHSQESH.
OrthoDBi EOG7PS1FZ.
PhylomeDBi Q5MJ70.
TreeFami TF329827.

Miscellaneous databases

ChiTaRSi SPDYA. human.
GeneWikii SPDYA.
GenomeRNAii 245711.
NextBioi 91722.
PROi Q5MJ70.
SOURCEi Search...

Gene expression databases

Bgeei Q5MJ70.
CleanExi HS_SPDYA.
ExpressionAtlasi Q5MJ70. baseline and differential.
Genevestigatori Q5MJ70.

Family and domain databases

InterProi IPR020984. Cell_cycle_regulatory_Spy1.
[Graphical view ]
Pfami PF11357. Spy1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2."
    Porter L.A., Dellinger R.W., Tynan J.A., Barnes E.A., Kong M., Lenormand J.-L., Donoghue D.J.
    J. Cell Biol. 157:357-366(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CDK2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis1 Publication.
  2. "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins."
    Cheng A., Xiong W., Ferrell J.E. Jr., Solomon M.J.
    Cell Cycle 4:155-165(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: TestisImported.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: TestisImported.
  5. "Human Spy1 promotes survival of mammalian cells following DNA damage."
    Barnes E.A., Porter L.A., Lenormand J.-L., Dellinger R.W., Donoghue D.J.
    Cancer Res. 63:3701-3707(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDK2.
  6. "Spy1 interacts with p27Kip1 to allow G1/S progression."
    Porter L.A., Kong-Beltran M., Donoghue D.J.
    Mol. Biol. Cell 14:3664-3674(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDKN1B, IDENTIFICATION IN A COMPLEX WITH CDKN1B AND CDK2, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSPDYA_HUMAN
AccessioniPrimary (citable) accession number: Q5MJ70
Secondary accession number(s): Q53R05, Q5MJ69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3