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Protein

F-box/LRR-repeat protein 16

Gene

Fbxl16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-8951664 Neddylation
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
Spinal cord injury and regeneration-related protein 1
Gene namesi
Name:Fbxl16
Synonyms:Scirr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1309127 Fbxl16

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198641 – 479F-box/LRR-repeat protein 16Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ5MJ12
PRIDEiQ5MJ12

PTM databases

iPTMnetiQ5MJ12
PhosphoSitePlusiQ5MJ12

Expressioni

Gene expression databases

BgeeiENSRNOG00000022248

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi268840, 1 interactor
STRINGi10116.ENSRNOP00000035846

Structurei

3D structure databases

ProteinModelPortaliQ5MJ12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 139F-boxAdd BLAST46
Repeati244 – 266LRR 1Add BLAST23
Repeati267 – 290LRR 2Add BLAST24
Repeati319 – 343LRR 3Add BLAST25
Repeati345 – 369LRR 4Add BLAST25
Repeati371 – 395LRR 5Add BLAST25
Repeati396 – 420LRR 6Add BLAST25
Repeati446 – 470LRR 7Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 94Pro-richAdd BLAST85

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT21 Eukaryota
ENOG410XQRM LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000060108
HOVERGENiHBG051675
InParanoidiQ5MJ12
KOiK10282
OMAiAAKNRLC
OrthoDBiEOG091G0NN8
PhylomeDBiQ5MJ12
TreeFamiTF324260

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
SMARTiView protein in SMART
SM00367 LRR_CC, 7 hits
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q5MJ12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPGIDGDP KPSCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP
60 70 80 90 100
PPPTLPPPSL ATPLSRVALA GGPCPPASGP ASGPVPGPPV ERPPLATDEK
110 120 130 140 150
ILNGLFWYFS ACEKCILAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL
160 170 180 190 200
PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYSL SKKGVKAMSL
210 220 230 240 250
KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS
260 270 280 290 300
DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
310 320 330 340 350
LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS
360 370 380 390 400
LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR
410 420 430 440 450
SLYLRWCCQV QDFGLKHLLA MRSLRLLSLA GCPLLTTTGL SGLVQLQELE
460 470
ELELTNCPGA TPELFKYFSQ HLPRCLVIE
Length:479
Mass (Da):51,851
Last modified:February 1, 2005 - v1
Checksum:i7694D186ECEF22F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823669 mRNA Translation: AAV85776.1
RefSeqiNP_001009504.1, NM_001009504.1
XP_006246082.1, XM_006246020.3
XP_017452931.1, XM_017597442.1
UniGeneiRn.214871

Genome annotation databases

EnsembliENSRNOT00000039777; ENSRNOP00000035846; ENSRNOG00000022248
GeneIDi494223
KEGGirno:494223
UCSCiRGD:1309127 rat

Similar proteinsi

Entry informationi

Entry nameiFXL16_RAT
AccessioniPrimary (citable) accession number: Q5MJ12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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