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Protein

F-box/LRR-repeat protein 16

Gene

Fbxl16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
Spinal cord injury and regeneration-related protein 1
Gene namesi
Name:Fbxl16
Synonyms:Scirr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1309127. Fbxl16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198641 – 479F-box/LRR-repeat protein 16Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ5MJ12.
PRIDEiQ5MJ12.

PTM databases

iPTMnetiQ5MJ12.
PhosphoSitePlusiQ5MJ12.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022248.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi268840. 1 interactor.
STRINGi10116.ENSRNOP00000035846.

Structurei

3D structure databases

ProteinModelPortaliQ5MJ12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 139F-boxAdd BLAST46
Repeati244 – 266LRR 1Add BLAST23
Repeati267 – 290LRR 2Add BLAST24
Repeati319 – 343LRR 3Add BLAST25
Repeati345 – 369LRR 4Add BLAST25
Repeati371 – 395LRR 5Add BLAST25
Repeati396 – 420LRR 6Add BLAST25
Repeati446 – 470LRR 7Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 94Pro-richAdd BLAST85

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT21. Eukaryota.
ENOG410XQRM. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000060108.
HOVERGENiHBG051675.
InParanoidiQ5MJ12.
KOiK10282.
OMAiNCPGATA.
OrthoDBiEOG091G0NN8.
PhylomeDBiQ5MJ12.
TreeFamiTF324260.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 7 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5MJ12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPGIDGDP KPSCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP
60 70 80 90 100
PPPTLPPPSL ATPLSRVALA GGPCPPASGP ASGPVPGPPV ERPPLATDEK
110 120 130 140 150
ILNGLFWYFS ACEKCILAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL
160 170 180 190 200
PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYSL SKKGVKAMSL
210 220 230 240 250
KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS
260 270 280 290 300
DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
310 320 330 340 350
LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS
360 370 380 390 400
LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR
410 420 430 440 450
SLYLRWCCQV QDFGLKHLLA MRSLRLLSLA GCPLLTTTGL SGLVQLQELE
460 470
ELELTNCPGA TPELFKYFSQ HLPRCLVIE
Length:479
Mass (Da):51,851
Last modified:February 1, 2005 - v1
Checksum:i7694D186ECEF22F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823669 mRNA. Translation: AAV85776.1.
RefSeqiNP_001009504.1. NM_001009504.1.
XP_006246082.1. XM_006246020.3.
XP_017452931.1. XM_017597442.1.
UniGeneiRn.214871.

Genome annotation databases

EnsembliENSRNOT00000039777; ENSRNOP00000035846; ENSRNOG00000022248.
GeneIDi494223.
KEGGirno:494223.
UCSCiRGD:1309127. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823669 mRNA. Translation: AAV85776.1.
RefSeqiNP_001009504.1. NM_001009504.1.
XP_006246082.1. XM_006246020.3.
XP_017452931.1. XM_017597442.1.
UniGeneiRn.214871.

3D structure databases

ProteinModelPortaliQ5MJ12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi268840. 1 interactor.
STRINGi10116.ENSRNOP00000035846.

PTM databases

iPTMnetiQ5MJ12.
PhosphoSitePlusiQ5MJ12.

Proteomic databases

PaxDbiQ5MJ12.
PRIDEiQ5MJ12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039777; ENSRNOP00000035846; ENSRNOG00000022248.
GeneIDi494223.
KEGGirno:494223.
UCSCiRGD:1309127. rat.

Organism-specific databases

CTDi146330.
RGDi1309127. Fbxl16.

Phylogenomic databases

eggNOGiENOG410IT21. Eukaryota.
ENOG410XQRM. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000060108.
HOVERGENiHBG051675.
InParanoidiQ5MJ12.
KOiK10282.
OMAiNCPGATA.
OrthoDBiEOG091G0NN8.
PhylomeDBiQ5MJ12.
TreeFamiTF324260.

Enzyme and pathway databases

ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ5MJ12.

Gene expression databases

BgeeiENSRNOG00000022248.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 7 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFXL16_RAT
AccessioniPrimary (citable) accession number: Q5MJ12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.