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Protein

Sperm protein associated with the nucleus on the X chromosome N4

Gene

SPANXN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome N4
Alternative name(s):
Nuclear-associated protein SPAN-Xn4
Short name:
SPANX-N4
SPANX family member N4
Gene namesi
Name:SPANXN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189326.4.
HGNCiHGNC:33177. SPANXN4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189326.
PharmGKBiPA162404394.

Polymorphism and mutation databases

BioMutaiSPANXN4.
DMDMi74706909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002855411 – 99Sperm protein associated with the nucleus on the X chromosome N4Add BLAST99

Proteomic databases

PaxDbiQ5MJ08.
PeptideAtlasiQ5MJ08.
PRIDEiQ5MJ08.

PTM databases

iPTMnetiQ5MJ08.
PhosphoSitePlusiQ5MJ08.

Expressioni

Gene expression databases

BgeeiENSG00000189326.
CleanExiHS_SPANXN4.
ExpressionAtlasiQ5MJ08. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi137551. 1 interactor.
IntActiQ5MJ08. 2 interactors.
STRINGi9606.ENSP00000405210.

Structurei

3D structure databases

ProteinModelPortaliQ5MJ08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiENOG410JGTZ. Eukaryota.
ENOG41118WP. LUCA.
GeneTreeiENSGT00530000064247.
HOGENOMiHOG000015252.
HOVERGENiHBG097736.
InParanoidiQ5MJ08.
PhylomeDBiQ5MJ08.
TreeFamiTF341404.

Family and domain databases

InterProiView protein in InterPro
IPR010007. SPAN-X_fam.
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiView protein in Pfam
PF07458. SPAN-X. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5MJ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPTSSTNE NKMKSPCESN KRKVDKKKKN LHRASAPEQS LKETEKAKYP
60 70 80 90
TLVFYCRKNK KRNSNQLENN QPTESSTDPI KEKGDLDISA GSPQDGGQN
Length:99
Mass (Da):11,168
Last modified:February 1, 2005 - v1
Checksum:iA0B8381B8A11B5BB
GO

Sequence cautioni

The sequence CAH71622 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03202748K → N1 PublicationCorresponds to variant dbSNP:rs10482390Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825032 Genomic DNA. Translation: AAV97588.1.
DQ336126 mRNA. Translation: ABC61877.1.
DQ336127 mRNA. Translation: ABC61878.1.
AL137840 Genomic DNA. Translation: CAH71622.1. Sequence problems.
BC130503 mRNA. Translation: AAI30504.1.
BC130505 mRNA. Translation: AAI30506.1.
CCDSiCCDS48178.1.
RefSeqiNP_001009613.1. NM_001009613.2.
UniGeneiHs.535082.

Genome annotation databases

EnsembliENST00000446864; ENSP00000405210; ENSG00000189326.
GeneIDi441525.
KEGGihsa:441525.
UCSCiuc004fbv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiSPXN4_HUMAN
AccessioniPrimary (citable) accession number: Q5MJ08
Secondary accession number(s): Q0ZNK6, Q5W0S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 1, 2005
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families