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Protein

Sperm protein associated with the nucleus on the X chromosome N4

Gene

SPANXN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome N4
Alternative name(s):
Nuclear-associated protein SPAN-Xn4
Short name:
SPANX-N4
SPANX family member N4
Gene namesi
Name:SPANXN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33177. SPANXN4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404394.

Polymorphism and mutation databases

BioMutaiSPANXN4.
DMDMi74706909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Sperm protein associated with the nucleus on the X chromosome N4PRO_0000285541Add
BLAST

Proteomic databases

PaxDbiQ5MJ08.
PRIDEiQ5MJ08.

PTM databases

iPTMnetiQ5MJ08.
PhosphoSiteiQ5MJ08.

Expressioni

Gene expression databases

BgeeiQ5MJ08.
CleanExiHS_SPANXN4.
ExpressionAtlasiQ5MJ08. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi137551. 1 interaction.
IntActiQ5MJ08. 2 interactions.
STRINGi9606.ENSP00000405210.

Structurei

3D structure databases

ProteinModelPortaliQ5MJ08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiENOG410JGTZ. Eukaryota.
ENOG41118WP. LUCA.
GeneTreeiENSGT00530000064247.
HOGENOMiHOG000015252.
HOVERGENiHBG097736.
InParanoidiQ5MJ08.
OrthoDBiEOG7C2R2W.
PhylomeDBiQ5MJ08.
TreeFamiTF341404.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5MJ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPTSSTNE NKMKSPCESN KRKVDKKKKN LHRASAPEQS LKETEKAKYP
60 70 80 90
TLVFYCRKNK KRNSNQLENN QPTESSTDPI KEKGDLDISA GSPQDGGQN
Length:99
Mass (Da):11,168
Last modified:February 1, 2005 - v1
Checksum:iA0B8381B8A11B5BB
GO

Sequence cautioni

The sequence CAH71622.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481K → N.1 Publication
Corresponds to variant rs10482390 [ dbSNP | Ensembl ].
VAR_032027

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825032 Genomic DNA. Translation: AAV97588.1.
DQ336126 mRNA. Translation: ABC61877.1.
DQ336127 mRNA. Translation: ABC61878.1.
AL137840 Genomic DNA. Translation: CAH71622.1. Sequence problems.
BC130503 mRNA. Translation: AAI30504.1.
BC130505 mRNA. Translation: AAI30506.1.
CCDSiCCDS48178.1.
RefSeqiNP_001009613.1. NM_001009613.2.
UniGeneiHs.535082.

Genome annotation databases

EnsembliENST00000446864; ENSP00000405210; ENSG00000189326.
GeneIDi441525.
KEGGihsa:441525.
UCSCiuc004fbv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825032 Genomic DNA. Translation: AAV97588.1.
DQ336126 mRNA. Translation: ABC61877.1.
DQ336127 mRNA. Translation: ABC61878.1.
AL137840 Genomic DNA. Translation: CAH71622.1. Sequence problems.
BC130503 mRNA. Translation: AAI30504.1.
BC130505 mRNA. Translation: AAI30506.1.
CCDSiCCDS48178.1.
RefSeqiNP_001009613.1. NM_001009613.2.
UniGeneiHs.535082.

3D structure databases

ProteinModelPortaliQ5MJ08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137551. 1 interaction.
IntActiQ5MJ08. 2 interactions.
STRINGi9606.ENSP00000405210.

PTM databases

iPTMnetiQ5MJ08.
PhosphoSiteiQ5MJ08.

Polymorphism and mutation databases

BioMutaiSPANXN4.
DMDMi74706909.

Proteomic databases

PaxDbiQ5MJ08.
PRIDEiQ5MJ08.

Protocols and materials databases

DNASUi441525.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446864; ENSP00000405210; ENSG00000189326.
GeneIDi441525.
KEGGihsa:441525.
UCSCiuc004fbv.4. human.

Organism-specific databases

CTDi441525.
GeneCardsiSPANXN4.
HGNCiHGNC:33177. SPANXN4.
MIMi300667. gene.
neXtProtiNX_Q5MJ08.
PharmGKBiPA162404394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JGTZ. Eukaryota.
ENOG41118WP. LUCA.
GeneTreeiENSGT00530000064247.
HOGENOMiHOG000015252.
HOVERGENiHBG097736.
InParanoidiQ5MJ08.
OrthoDBiEOG7C2R2W.
PhylomeDBiQ5MJ08.
TreeFamiTF341404.

Miscellaneous databases

GenomeRNAii441525.
PROiQ5MJ08.
SOURCEiSearch...

Gene expression databases

BgeeiQ5MJ08.
CleanExiHS_SPANXN4.
ExpressionAtlasiQ5MJ08. baseline and differential.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids."
    Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G., Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.
    Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."
    Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.
    Genome Res. 15:1477-1486(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-48.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSPXN4_HUMAN
AccessioniPrimary (citable) accession number: Q5MJ08
Secondary accession number(s): Q0ZNK6, Q5W0S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 1, 2005
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.