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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2M
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004182321 – 118Beta-2-microglobulinAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).By similarity

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011347

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Beta strandi41 – 53Combined sources13
Beta strandi56 – 61Combined sources6
Beta strandi81 – 89Combined sources9
Beta strandi97 – 102Combined sources6
Beta strandi110 – 113Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XMFX-ray2.10B21-118[»]
5XMMX-ray2.90B21-118[»]
ProteinModelPortaliQ5MGS7
SMRiQ5MGS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 113Ig-like C1-typeAdd BLAST89

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A Eukaryota
ENOG410YTDG LUCA
HOGENOMiHOG000043084
HOVERGENiHBG006197
InParanoidiQ5MGS7
KOiK08055
TreeFamiTF334167

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015707 B2Microglobulin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PANTHERiPTHR19944:SF62 PTHR19944:SF62, 1 hit
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5MGS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFVVLVLL GLLYLSHLDA VQHSPKVQVY SRHPAENGKP NFLNCYVSGF
60 70 80 90 100
HPPQIDITLM KNGKKMEAEQ TDLSFNRDWT FYLLVHTEFT PTVEDEYSCQ
110
VNHTTLSEPK VVKWDRDM
Length:118
Mass (Da):13,698
Last modified:February 1, 2005 - v1
Checksum:i1C8E2AA6055EAA44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY829266 mRNA Translation: AAV88621.1
RefSeqiNP_001009876.1, NM_001009876.1

Genome annotation databases

GeneIDi494145
KEGGifca:494145

Similar proteinsi

Entry informationi

Entry nameiB2MG_FELCA
AccessioniPrimary (citable) accession number: Q5MGS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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