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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2M
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 11898Beta-2-microglobulinPRO_0000041823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).By similarity

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011347.

Structurei

3D structure databases

ProteinModelPortaliQ5MGS7.
SMRiQ5MGS7. Positions 19-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11389Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ5MGS7.
KOiK08055.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5MGS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFVVLVLL GLLYLSHLDA VQHSPKVQVY SRHPAENGKP NFLNCYVSGF
60 70 80 90 100
HPPQIDITLM KNGKKMEAEQ TDLSFNRDWT FYLLVHTEFT PTVEDEYSCQ
110
VNHTTLSEPK VVKWDRDM
Length:118
Mass (Da):13,698
Last modified:February 1, 2005 - v1
Checksum:i1C8E2AA6055EAA44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY829266 mRNA. Translation: AAV88621.1.
RefSeqiNP_001009876.1. NM_001009876.1.

Genome annotation databases

GeneIDi494145.
KEGGifca:494145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY829266 mRNA. Translation: AAV88621.1.
RefSeqiNP_001009876.1. NM_001009876.1.

3D structure databases

ProteinModelPortaliQ5MGS7.
SMRiQ5MGS7. Positions 19-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi494145.
KEGGifca:494145.

Organism-specific databases

CTDi567.

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ5MGS7.
KOiK08055.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2MG_FELCA
AccessioniPrimary (citable) accession number: Q5MGS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.