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Q5MD62 (CCR7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 7

Short name=C-C CKR-7
Short name=CC-CKR-7
Short name=CCR-7
Alternative name(s):
CD_antigen=CD197
Gene names
Name:CCR7
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the MIP-3-beta chemokine By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 379355C-C chemokine receptor type 7
PRO_0000291858

Regions

Topological domain25 – 5935Extracellular Potential
Transmembrane60 – 8627Helical; Name=1; Potential
Topological domain87 – 959Cytoplasmic Potential
Transmembrane96 – 11621Helical; Name=2; Potential
Topological domain117 – 13014Extracellular Potential
Transmembrane131 – 15222Helical; Name=3; Potential
Topological domain153 – 17018Cytoplasmic Potential
Transmembrane171 – 19121Helical; Name=4; Potential
Topological domain192 – 21928Extracellular Potential
Transmembrane220 – 24728Helical; Name=5; Potential
Topological domain248 – 26316Cytoplasmic Potential
Transmembrane264 – 28926Helical; Name=6; Potential
Topological domain290 – 31425Extracellular Potential
Transmembrane315 – 33218Helical; Name=7; Potential
Topological domain333 – 37947Cytoplasmic Potential

Amino acid modifications

Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation2921N-linked (GlcNAc...) Potential
Disulfide bond129 ↔ 210 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5MD62 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: E90D69FA0BC6C80D

FASTA37942,875
        10         20         30         40         50         60 
MDLGKPMKNV LVVALLVIFQ VCLCQDEVTD NYIGDNTTVD YTLYESVCFK KDVRNFKAWF 

        70         80         90        100        110        120 
LPIMYSIICF VGLLGNGLVM LTYIYFKRLK TMTDTYLLNL ALADILFLLT LPFWAYSAAK 

       130        140        150        160        170        180 
SWVFGVHVCK LIFGIYKISF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCL 

       190        200        210        220        230        240 
GIWMLAIVLS TPEVMYSGIQ KSSSEQALRC SLVTEHVEAL ITIQVAQMVV GFLIPLMAMS 

       250        260        270        280        290        300 
FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFVAFQLPYN GVVLAHTVAN FNITSGTSCE 

       310        320        330        340        350        360 
LSKQLNIAYD VTYSLACVRC CVNPFLYAFI GVKFRSDLFK LFKDLGCLSQ EQLRQWSFCR 

       370 
HTRRSSMSVE AETTTTFSP 

« Hide

References

[1]"Molecular cloning of bovine chemokine receptors and expression by WC1+ gammadelta T cells."
Blumerman S.L., Wang F., Herzig C.T., Baldwin C.L.
Dev. Comp. Immunol. 31:87-102(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY834253 mRNA. Translation: AAV97930.1.
UniGeneBt.20643.

3D structure databases

ProteinModelPortalQ5MD62.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG149643.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ5MD62.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCR7_BOVIN
AccessionPrimary (citable) accession number: Q5MD62
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries