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Protein

C-C chemokine receptor type 7

Gene

CCR7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the MIP-3-beta chemokine.By similarity

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. immune response Source: InterPro
  3. inflammatory response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 7
Short name:
C-C CKR-7
Short name:
CC-CKR-7
Short name:
CCR-7
Alternative name(s):
CD_antigen: CD197
Gene namesi
Name:CCR7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 5935ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8627Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini87 – 959CytoplasmicSequence Analysis
Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini117 – 13014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini153 – 17018CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini192 – 21928ExtracellularSequence AnalysisAdd
BLAST
Transmembranei220 – 24728Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini248 – 26316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28926Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini290 – 31425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei315 – 33218Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini333 – 37947CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 379355C-C chemokine receptor type 7PRO_0000291858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 210PROSITE-ProRule annotation
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5MD62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149643.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ5MD62.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5MD62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLGKPMKNV LVVALLVIFQ VCLCQDEVTD NYIGDNTTVD YTLYESVCFK
60 70 80 90 100
KDVRNFKAWF LPIMYSIICF VGLLGNGLVM LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
ALADILFLLT LPFWAYSAAK SWVFGVHVCK LIFGIYKISF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCL GIWMLAIVLS TPEVMYSGIQ
210 220 230 240 250
KSSSEQALRC SLVTEHVEAL ITIQVAQMVV GFLIPLMAMS FCYLVIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFVAFQLPYN GVVLAHTVAN FNITSGTSCE
310 320 330 340 350
LSKQLNIAYD VTYSLACVRC CVNPFLYAFI GVKFRSDLFK LFKDLGCLSQ
360 370
EQLRQWSFCR HTRRSSMSVE AETTTTFSP
Length:379
Mass (Da):42,875
Last modified:February 1, 2005 - v1
Checksum:iE90D69FA0BC6C80D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY834253 mRNA. Translation: AAV97930.1.
UniGeneiBt.20643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY834253 mRNA. Translation: AAV97930.1.
UniGeneiBt.20643.

3D structure databases

ProteinModelPortaliQ5MD62.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG149643.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ5MD62.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of bovine chemokine receptors and expression by WC1+ gammadelta T cells."
    Blumerman S.L., Wang F., Herzig C.T., Baldwin C.L.
    Dev. Comp. Immunol. 31:87-102(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCR7_BOVIN
AccessioniPrimary (citable) accession number: Q5MD62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 1, 2005
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.