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Q5MD62

- CCR7_BOVIN

UniProt

Q5MD62 - CCR7_BOVIN

Protein

C-C chemokine receptor type 7

Gene

CCR7

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Receptor for the MIP-3-beta chemokine.By similarity

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: InterPro
    2. immune response Source: InterPro
    3. inflammatory response Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 7
    Short name:
    C-C CKR-7
    Short name:
    CC-CKR-7
    Short name:
    CCR-7
    Alternative name(s):
    CD_antigen: CD197
    Gene namesi
    Name:CCR7
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 379355C-C chemokine receptor type 7PRO_0000291858Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi129 ↔ 210PROSITE-ProRule annotation
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5MD62.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 5935ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini87 – 959CytoplasmicSequence Analysis
    Topological domaini117 – 13014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 17018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini192 – 21928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 37947CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24728Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28926Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33218Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149643.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ5MD62.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5MD62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLGKPMKNV LVVALLVIFQ VCLCQDEVTD NYIGDNTTVD YTLYESVCFK    50
    KDVRNFKAWF LPIMYSIICF VGLLGNGLVM LTYIYFKRLK TMTDTYLLNL 100
    ALADILFLLT LPFWAYSAAK SWVFGVHVCK LIFGIYKISF FSGMLLLLCI 150
    SIDRYVAIVQ AVSAHRHRAR VLLISKLSCL GIWMLAIVLS TPEVMYSGIQ 200
    KSSSEQALRC SLVTEHVEAL ITIQVAQMVV GFLIPLMAMS FCYLVIIRTL 250
    LQARNFERNK AIKVIIAVVV VFVAFQLPYN GVVLAHTVAN FNITSGTSCE 300
    LSKQLNIAYD VTYSLACVRC CVNPFLYAFI GVKFRSDLFK LFKDLGCLSQ 350
    EQLRQWSFCR HTRRSSMSVE AETTTTFSP 379
    Length:379
    Mass (Da):42,875
    Last modified:February 1, 2005 - v1
    Checksum:iE90D69FA0BC6C80D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY834253 mRNA. Translation: AAV97930.1.
    UniGeneiBt.20643.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY834253 mRNA. Translation: AAV97930.1 .
    UniGenei Bt.20643.

    3D structure databases

    ProteinModelPortali Q5MD62.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG149643.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q5MD62.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of bovine chemokine receptors and expression by WC1+ gammadelta T cells."
      Blumerman S.L., Wang F., Herzig C.T., Baldwin C.L.
      Dev. Comp. Immunol. 31:87-102(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCR7_BOVIN
    AccessioniPrimary (citable) accession number: Q5MD62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3