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Protein

C-C chemokine receptor type 7

Gene

CCR7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the MIP-3-beta chemokine.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 7
Short name:
C-C CKR-7
Short name:
CC-CKR-7
Short name:
CCR-7
Alternative name(s):
CD_antigen: CD197
Gene namesi
Name:CCR7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 59ExtracellularSequence analysisAdd BLAST35
Transmembranei60 – 86Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini87 – 95CytoplasmicSequence analysis9
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini117 – 130ExtracellularSequence analysisAdd BLAST14
Transmembranei131 – 152Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini153 – 170CytoplasmicSequence analysisAdd BLAST18
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 219ExtracellularSequence analysisAdd BLAST28
Transmembranei220 – 247Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini248 – 263CytoplasmicSequence analysisAdd BLAST16
Transmembranei264 – 289Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini290 – 314ExtracellularSequence analysisAdd BLAST25
Transmembranei315 – 332Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini333 – 379CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000029185825 – 379C-C chemokine receptor type 7Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 210PROSITE-ProRule annotation
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5MD62.
PRIDEiQ5MD62.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052953.

Structurei

3D structure databases

ProteinModelPortaliQ5MD62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ5MD62.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5MD62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGKPMKNV LVVALLVIFQ VCLCQDEVTD NYIGDNTTVD YTLYESVCFK
60 70 80 90 100
KDVRNFKAWF LPIMYSIICF VGLLGNGLVM LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
ALADILFLLT LPFWAYSAAK SWVFGVHVCK LIFGIYKISF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCL GIWMLAIVLS TPEVMYSGIQ
210 220 230 240 250
KSSSEQALRC SLVTEHVEAL ITIQVAQMVV GFLIPLMAMS FCYLVIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFVAFQLPYN GVVLAHTVAN FNITSGTSCE
310 320 330 340 350
LSKQLNIAYD VTYSLACVRC CVNPFLYAFI GVKFRSDLFK LFKDLGCLSQ
360 370
EQLRQWSFCR HTRRSSMSVE AETTTTFSP
Length:379
Mass (Da):42,875
Last modified:February 1, 2005 - v1
Checksum:iE90D69FA0BC6C80D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY834253 mRNA. Translation: AAV97930.1.
UniGeneiBt.20643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY834253 mRNA. Translation: AAV97930.1.
UniGeneiBt.20643.

3D structure databases

ProteinModelPortaliQ5MD62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052953.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5MD62.
PRIDEiQ5MD62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ5MD62.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR7_BOVIN
AccessioniPrimary (citable) accession number: Q5MD62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 1, 2005
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.