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Q5MAI5 (CDKL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 4

EC=2.7.11.22
Gene names
Name:CDKL4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm Probable.

Domain

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Cyclin-dependent kinase-like 4
PRO_0000085824

Regions

Domain4 – 286283Protein kinase
Nucleotide binding10 – 189ATP By similarity
Motif45 – 517[NKR]KIAxRE

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Natural variations

Natural variant381S → P. Ref.2
Corresponds to variant rs35947084 [ dbSNP | Ensembl ].
VAR_041992
Natural variant531R → H. Ref.2
Corresponds to variant rs35454041 [ dbSNP | Ensembl ].
VAR_041993
Natural variant1181H → Y.
Corresponds to variant rs6731369 [ dbSNP | Ensembl ].
VAR_053930
Natural variant2281F → C. Ref.2
Corresponds to variant rs56353587 [ dbSNP | Ensembl ].
VAR_041994
Natural variant2881S → Y. Ref.2
Corresponds to variant rs34819676 [ dbSNP | Ensembl ].
VAR_041995
Natural variant3071R → C. Ref.2
Corresponds to variant rs56330730 [ dbSNP | Ensembl ].
VAR_041996

Sequences

Sequence LengthMass (Da)Tools
Q5MAI5 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: C40EFF6A79FF5966

FASTA31536,223
        10         20         30         40         50         60 
MEKYEKLAKT GEGSYGVVFK CRNKTSGQVV AVKKFVESED DPVVKKIALR EIRMLKQLKH 

        70         80         90        100        110        120 
PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVAD GVIKSVLWQT LQALNFCHIH 

       130        140        150        160        170        180 
NCIHRDIKPE NILITKQGII KICDFGFAQI LIPGDAYTDY VATRWYRAPE LLVGDTQYGS 

       190        200        210        220        230        240 
SVDIWAIGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFKS NGFFHGISIP 

       250        260        270        280        290        300 
EPEDMETLEE KFSDVHPVAL NFMKGCLKMN PDDRLTCSQL LESSYFDSFQ EAQIKRKARN 

       310 
EGRNRRRQQV LPLKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY845084 mRNA. Translation: AAW30008.1.
RefSeqNP_001009565.1. NM_001009565.1.
UniGeneHs.403201.

3D structure databases

ProteinModelPortalQ5MAI5.
SMRQ5MAI5. Positions 2-290.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY1985.

PTM databases

PhosphoSiteQ5MAI5.

Polymorphism databases

DMDM74762208.

Proteomic databases

PaxDbQ5MAI5.
PRIDEQ5MAI5.

Protocols and materials databases

DNASU344387.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378803; ENSP00000368080; ENSG00000205111.
GeneID344387.
KEGGhsa:344387.
UCSCuc002rrm.3. human.

Organism-specific databases

CTD344387.
GeneCardsGC02M039402.
HGNCHGNC:19287. CDKL4.
neXtProtNX_Q5MAI5.
PharmGKBPA134892546.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
KOK08824.
PhylomeDBQ5MAI5.
TreeFamTF101031.

Enzyme and pathway databases

SignaLinkQ5MAI5.

Gene expression databases

BgeeQ5MAI5.
CleanExHS_CDKL4.
GenevestigatorQ5MAI5.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi344387.
NextBio98684.
PROQ5MAI5.

Entry information

Entry nameCDKL4_HUMAN
AccessionPrimary (citable) accession number: Q5MAI5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM