Q5MAI5 (CDKL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase-like 4
EC=2.7.11.22

Gene names

Name:

CDKL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm Probable.
Domain	The [NKR]KIAxRE motif seems to be a cyclin-binding region.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Cyclin-dependent kinase-like 4		PRO_0000085824
Regions
	Domain	4 – 286	283	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
	Motif	45 – 51	7	[NKR]KIAxRE
Sites
	Active site	126	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity
Natural variations
	Natural variant	38	1	S → P. Ref.2 Corresponds to variant rs35947084 [ dbSNP | Ensembl ].		VAR_041992
	Natural variant	53	1	R → H. Ref.2 Corresponds to variant rs35454041 [ dbSNP | Ensembl ].		VAR_041993
	Natural variant	118	1	H → Y. Corresponds to variant rs6731369 [ dbSNP | Ensembl ].		VAR_053930
	Natural variant	228	1	F → C. Ref.2 Corresponds to variant rs56353587 [ dbSNP | Ensembl ].		VAR_041994
	Natural variant	288	1	S → Y. Ref.2 Corresponds to variant rs34819676 [ dbSNP | Ensembl ].		VAR_041995
	Natural variant	307	1	R → C. Ref.2 Corresponds to variant rs56330730 [ dbSNP | Ensembl ].		VAR_041996

Sequences

	Sequence		Length	Mass (Da)
	Q5MAI5 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: C40EFF6A79FF5966	FASTA	315	36,223
	10 20 30 40 50 60 MEKYEKLAKT GEGSYGVVFK CRNKTSGQVV AVKKFVESED DPVVKKIALR EIRMLKQLKH 70 80 90 100 110 120 PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVAD GVIKSVLWQT LQALNFCHIH 130 140 150 160 170 180 NCIHRDIKPE NILITKQGII KICDFGFAQI LIPGDAYTDY VATRWYRAPE LLVGDTQYGS 190 200 210 220 230 240 SVDIWAIGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFKS NGFFHGISIP 250 260 270 280 290 300 EPEDMETLEE KFSDVHPVAL NFMKGCLKMN PDDRLTCSQL LESSYFDSFQ EAQIKRKARN 310 EGRNRRRQQV LPLKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of human cyclin-dependent kinase-like 4." Wang P.Z., Wang F., Wang X., Wu J. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-38; HIS-53; CYS-228; TYR-288 AND CYS-307.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY845084 mRNA. Translation: AAW30008.1.
IPI	IPI00872721.
RefSeq	NP_001009565.1. NM_001009565.1.
UniGene	Hs.403201.
3D structure databases
ProteinModelPortal	Q5MAI5.
ModBase	Search...
PTM databases
PhosphoSite	Q5MAI5.
Polymorphism databases
DMDM	74762208.
Proteomic databases
PaxDb	Q5MAI5.
PRIDE	Q5MAI5.
Protocols and materials databases
DNASU	344387.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378803; ENSP00000368080; ENSG00000205111.
GeneID	344387.
KEGG	hsa:344387.
UCSC	uc002rrm.3. human.
Organism-specific databases
CTD	344387.
GeneCards	GC02M039402.
HGNC	HGNC:19287. CDKL4.
neXtProt	NX_Q5MAI5.
PharmGKB	PA134892546.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233024.
HOVERGEN	HBG014652.
KO	K08824.
Gene expression databases
ArrayExpress	Q5MAI5.
Bgee	Q5MAI5.
CleanEx	HS_CDKL4.
Genevestigator	Q5MAI5.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	344387.
NextBio	98684.

Entry information

Entry name

CDKL4_HUMAN

Accession

Primary (citable) accession number: Q5MAI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.