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Protein

NKAP-like protein

Gene

NKAPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NKAP-like protein
Gene namesi
Name:NKAPL
Synonyms:C6orf194
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000189134.3.
HGNCiHGNC:21584. NKAPL.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi222698.
OpenTargetsiENSG00000189134.
PharmGKBiPA162397607.

Polymorphism and mutation databases

DMDMi313104209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600781 – 402NKAP-like proteinAdd BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5M9Q1.
MaxQBiQ5M9Q1.
PaxDbiQ5M9Q1.
PeptideAtlasiQ5M9Q1.
PRIDEiQ5M9Q1.

PTM databases

iPTMnetiQ5M9Q1.
PhosphoSitePlusiQ5M9Q1.

Expressioni

Gene expression databases

BgeeiENSG00000189134.
CleanExiHS_NKAPL.
GenevisibleiQ5M9Q1. HS.

Interactioni

Subunit structurei

Interacts with RBPJ, CIR1 and HDAC3.By similarity

Protein-protein interaction databases

BioGridi128814. 4 interactors.
IntActiQ5M9Q1. 2 interactors.
STRINGi9606.ENSP00000345716.

Structurei

3D structure databases

ProteinModelPortaliQ5M9Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi177 – 246Lys-richAdd BLAST70

Sequence similaritiesi

Belongs to the NKAP family.Curated

Phylogenomic databases

eggNOGiKOG2812. Eukaryota.
ENOG4111FVK. LUCA.
GeneTreeiENSGT00510000047021.
HOGENOMiHOG000049099.
HOVERGENiHBG068915.
InParanoidiQ5M9Q1.
OMAiHTSQDEK.
OrthoDBiEOG091G0NTO.
PhylomeDBiQ5M9Q1.
TreeFamiTF315333.

Family and domain databases

InterProiView protein in InterPro
IPR009269. NKAP.
PANTHERiPTHR13087. PTHR13087. 1 hit.
PfamiView protein in Pfam
PF06047. SynMuv_product. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M9Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPVSRSSYS EDIVGSRRRR RSSSGSPPSP QSRCSSWDGC SRSHSRGREG
60 70 80 90 100
LRPPWSELDV GALYPFSRSG SRGRLPRFRN YAFASSWSTS YSGYRYHRHC
110 120 130 140 150
YAEERQSAED YEKEESHRQR RLKERERIGE LGAPEVWGPS PKFPQLDSDE
160 170 180 190 200
HTPVEDEEEV THQKSSSSDS NSEEHRKKKT SRSRNKKKRK NKSSKRKHRK
210 220 230 240 250
YSDSDSNSES DTNSDSDDDK KRVKAKKKKK KKKHKTKKKK NKKTKKESSD
260 270 280 290 300
SSCKDSEEDL SEATWMEQPN VADTMDLIGP EAPIIHTSQD EKPLKYGHAL
310 320 330 340 350
LPGEGAAMAE YVKAGKRIPR RGEIGLTSEE IGSFECSGYV MSGSRHRRME
360 370 380 390 400
AVRLRKENQI YSADEKRALA SFNQEERRKR ESKILASFRE MVHKKTKEKD

DK
Length:402
Mass (Da):46,312
Last modified:November 30, 2010 - v3
Checksum:i071997D7635E219B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02899996Y → C1 PublicationCorresponds to variant dbSNP:rs12000Ensembl.1
Natural variantiVAR_029000152T → N. Corresponds to variant dbSNP:rs1635Ensembl.1
Natural variantiVAR_029001162H → Y. Corresponds to variant dbSNP:rs9461446Ensembl.1
Natural variantiVAR_029002398E → G1 PublicationCorresponds to variant dbSNP:rs1679709Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390721 Genomic DNA. No translation available.
BC038240 mRNA. Translation: AAH38240.1.
BC101681 mRNA. Translation: AAI01682.1.
BC101685 mRNA. Translation: AAI01686.1.
CCDSiCCDS34353.1.
RefSeqiNP_001007532.1. NM_001007531.2.
UniGeneiHs.48787.

Genome annotation databases

EnsembliENST00000343684; ENSP00000345716; ENSG00000189134.
GeneIDi222698.
KEGGihsa:222698.
UCSCiuc003nkt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNKAPL_HUMAN
AccessioniPrimary (citable) accession number: Q5M9Q1
Secondary accession number(s): Q3MIV1, Q9H4Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 30, 2010
Last modified: September 27, 2017
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families