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Q5M9N4

- PIGH_MOUSE

UniProt

Q5M9N4 - PIGH_MOUSE

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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

Gene

Pigh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi

GO - Molecular functioni

  1. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_243945. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class H protein
Short name:
PIG-H
Gene namesi
Name:Pigh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:99463. Pigh.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Phosphatidylinositol N-acetylglucosaminyltransferase subunit HPRO_0000281862Add
BLAST

Proteomic databases

PRIDEiQ5M9N4.

PTM databases

PhosphoSiteiQ5M9N4.

Expressioni

Gene expression databases

BgeeiQ5M9N4.
GenevestigatoriQ5M9N4.

Interactioni

Subunit structurei

Associates with PIGA, PIGC, PIGP, PIGQ and DPM2. The latter is not essential for activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072018.

Structurei

3D structure databases

ProteinModelPortaliQ5M9N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGH family.Curated

Phylogenomic databases

eggNOGiNOG266799.
GeneTreeiENSGT00390000011890.
HOGENOMiHOG000059602.
HOVERGENiHBG025632.
InParanoidiQ5M9N4.
KOiK03858.
OMAiVYKSCQE.
OrthoDBiEOG7VMP6N.
PhylomeDBiQ5M9N4.
TreeFamiTF324479.

Family and domain databases

InterProiIPR019328. GPI-GlcNAc_Trfase_PIG-H_dom.
[Graphical view]
PfamiPF10181. PIG-H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M9N4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDEKSFSDI CGGRLALRCR YYSPYCREFG LSSARLSLCS LTAVTCAVWL
60 70 80 90 100
AAYGLFTLCE NSMVLSATIF ITILGLLGYL HFVKIDQETL LIIDSLGIQM
110 120 130 140 150
TSSYASGKES TTFIEMDKVK DIIINEAIYM QKVIYYLCIL LKEPGKPHEI
160 170 180
SRVVPVFQSA KPRLDCLIEV YRSCQEVLAH QKATATSL
Length:188
Mass (Da):21,078
Last modified:February 1, 2005 - v1
Checksum:iC4C202F84A741A99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK167892 mRNA. Translation: BAE39904.1.
BC086806 mRNA. Translation: AAH86806.1.
CCDSiCCDS26006.1.
RefSeqiNP_084264.1. NM_029988.2.
UniGeneiMm.268317.

Genome annotation databases

EnsembliENSMUST00000072154; ENSMUSP00000072018; ENSMUSG00000021120.
GeneIDi110417.
KEGGimmu:110417.
UCSCiuc007nzs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK167892 mRNA. Translation: BAE39904.1 .
BC086806 mRNA. Translation: AAH86806.1 .
CCDSi CCDS26006.1.
RefSeqi NP_084264.1. NM_029988.2.
UniGenei Mm.268317.

3D structure databases

ProteinModelPortali Q5M9N4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000072018.

PTM databases

PhosphoSitei Q5M9N4.

Proteomic databases

PRIDEi Q5M9N4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072154 ; ENSMUSP00000072018 ; ENSMUSG00000021120 .
GeneIDi 110417.
KEGGi mmu:110417.
UCSCi uc007nzs.2. mouse.

Organism-specific databases

CTDi 5283.
MGIi MGI:99463. Pigh.

Phylogenomic databases

eggNOGi NOG266799.
GeneTreei ENSGT00390000011890.
HOGENOMi HOG000059602.
HOVERGENi HBG025632.
InParanoidi Q5M9N4.
KOi K03858.
OMAi VYKSCQE.
OrthoDBi EOG7VMP6N.
PhylomeDBi Q5M9N4.
TreeFami TF324479.

Enzyme and pathway databases

UniPathwayi UPA00196 .
Reactomei REACT_243945. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

NextBioi 363963.
PROi Q5M9N4.
SOURCEi Search...

Gene expression databases

Bgeei Q5M9N4.
Genevestigatori Q5M9N4.

Family and domain databases

InterProi IPR019328. GPI-GlcNAc_Trfase_PIG-H_dom.
[Graphical view ]
Pfami PF10181. PIG-H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: DBA/2.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiPIGH_MOUSE
AccessioniPrimary (citable) accession number: Q5M9N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3