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Q5M9N4 (PIGH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

EC=2.4.1.198
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class H protein
Short name=PIG-H
Gene names
Name:Pigh
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subunit structure

Associates with PIGA, PIGC, PIGP, PIGQ and DPM2. The latter is not essential for activity By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PIGH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
PRO_0000281862

Sequences

Sequence LengthMass (Da)Tools
Q5M9N4 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: C4C202F84A741A99

FASTA18821,078
        10         20         30         40         50         60 
MEDEKSFSDI CGGRLALRCR YYSPYCREFG LSSARLSLCS LTAVTCAVWL AAYGLFTLCE 

        70         80         90        100        110        120 
NSMVLSATIF ITILGLLGYL HFVKIDQETL LIIDSLGIQM TSSYASGKES TTFIEMDKVK 

       130        140        150        160        170        180 
DIIINEAIYM QKVIYYLCIL LKEPGKPHEI SRVVPVFQSA KPRLDCLIEV YRSCQEVLAH 


QKATATSL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: DBA/2.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK167892 mRNA. Translation: BAE39904.1.
BC086806 mRNA. Translation: AAH86806.1.
CCDSCCDS26006.1.
RefSeqNP_084264.1. NM_029988.2.
UniGeneMm.268317.

3D structure databases

ProteinModelPortalQ5M9N4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000072018.

PTM databases

PhosphoSiteQ5M9N4.

Proteomic databases

PRIDEQ5M9N4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072154; ENSMUSP00000072018; ENSMUSG00000021120.
GeneID110417.
KEGGmmu:110417.
UCSCuc007nzs.2. mouse.

Organism-specific databases

CTD5283.
MGIMGI:99463. Pigh.

Phylogenomic databases

eggNOGNOG266799.
GeneTreeENSGT00390000011890.
HOGENOMHOG000059602.
HOVERGENHBG025632.
InParanoidQ5M9N4.
KOK03858.
OMAVYKSCQE.
OrthoDBEOG7VMP6N.
PhylomeDBQ5M9N4.
TreeFamTF324479.

Enzyme and pathway databases

UniPathwayUPA00196.

Gene expression databases

BgeeQ5M9N4.
GenevestigatorQ5M9N4.

Family and domain databases

InterProIPR019328. GPI-GlcNAc_Trfase_PIG-H_dom.
[Graphical view]
PfamPF10181. PIG-H. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio363963.
PROQ5M9N4.
SOURCESearch...

Entry information

Entry namePIGH_MOUSE
AccessionPrimary (citable) accession number: Q5M9N4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot