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Protein

Coiled-coil domain-containing protein 158

Gene

CCDC158

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 158
Gene namesi
Name:CCDC158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163749.17
HGNCiHGNC:26374 CCDC158
neXtProtiNX_Q5M9N0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163749
PharmGKBiPA164717707

Polymorphism and mutation databases

BioMutaiCCDC158
DMDMi172045891

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257601 – 1113Coiled-coil domain-containing protein 158Add BLAST1113

Proteomic databases

MaxQBiQ5M9N0
PaxDbiQ5M9N0
PeptideAtlasiQ5M9N0
PRIDEiQ5M9N0

PTM databases

iPTMnetiQ5M9N0
PhosphoSitePlusiQ5M9N0

Expressioni

Gene expression databases

BgeeiENSG00000163749
GenevisibleiQ5M9N0 HS

Interactioni

Protein-protein interaction databases

BioGridi130969, 13 interactors
DIPiDIP-47314N
IntActiQ5M9N0, 9 interactors
STRINGi9606.ENSP00000373566

Structurei

3D structure databases

ProteinModelPortaliQ5M9N0
SMRiQ5M9N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 183Sequence analysisAdd BLAST112
Coiled coili243 – 833Sequence analysisAdd BLAST591
Coiled coili1061 – 1113Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 28Poly-Ser4
Compositional biasi948 – 1056Ser-richAdd BLAST109

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE3R Eukaryota
ENOG41102XW LUCA
GeneTreeiENSGT00390000013339
HOGENOMiHOG000111475
InParanoidiQ5M9N0
OMAiGMQKQIT
OrthoDBiEOG091G01IP
PhylomeDBiQ5M9N0
TreeFamiTF337019

Family and domain databases

InterProiView protein in InterPro
IPR031809 CCDC158
PfamiView protein in Pfam
PF15921 CCDC158, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5M9N0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESKAWESNN EDLLSSSGVT SNGGSSSSFF VSSIRGTIIE NTSSAGTLTQ
60 70 80 90 100
VPFFPKYEVE LDSPRKIIPS PGKEHFERVL EEYSHQVKDL QRRLNESNEL
110 120 130 140 150
HEKQKFYLRQ SVIDLQTKLQ EMQMERDAMA DIRRRESQSQ EDLRNQLQNT
160 170 180 190 200
VHELEAAKCL KEDMLKDSNT QIEQLRKMML SHEGVLQEIR SILVDFEEAS
210 220 230 240 250
GKKICEHDSM STLHFRSLGS AISKILRELD TEISYLKGRI FPVEDQLEAL
260 270 280 290 300
KSESQNKIEL LLQQHQDRIE QLISEHEVEI TGLTEKASSA RSQANSIQSQ
310 320 330 340 350
MEIIQEQARN QNSMYMRQLS DLESTVSQLR SELREAKRMY EDKTEELEKQ
360 370 380 390 400
LVLANSELTE ARTERDQFSQ ESGNLDDQLQ KLLADLHKRE KELSLEKEQN
410 420 430 440 450
KRLWDRDTGN SITIDHLRRE LDNRNMEVQR LEALLKALKS ECQGQMERQM
460 470 480 490 500
AAIQGKNESL EKVSSLTAQL ESTKEMLRKV VEELTAKKMT LESSERTISD
510 520 530 540 550
LTTSLQEKER AIEATNAEIT KLRSRVDLKL QELQHLKNEG DHLRNVQTEC
560 570 580 590 600
EALKLQMTEK DKVIEILRQQ IENMTQLVGQ HGRTAGAMQV EKAQLEKEIN
610 620 630 640 650
DRRMELKELK ILKDKKDAKI RELEARVSDL ELEKVKLVNA GSERLRAVKD
660 670 680 690 700
IKQERDQLLN EVKTSRSELN NLSEEYEVLK RNFRNKSEEM EMTTNKLKMQ
710 720 730 740 750
LKSAQSELEQ TRNTLKSMEG SDGHAMKVAM GMQKQITAKR GQIDALQSKI
760 770 780 790 800
QFLEEAMTNA NKEKHFLKEE KSKLSQELST VATEKNKMAG ELEVLRSQER
810 820 830 840 850
RLKEKVTNME VALDKASLQF AECQDIIQRQ EQESVRLKLQ HTLDIKELQG
860 870 880 890 900
PGYTSNSSLK PRLLQPASVT RSHSNVPSSQ STASFLSHHS TKANTLKEDP
910 920 930 940 950
TRDLKQLLQE LRSVINEEPA VSLSKTEEDG RTSLGALEDR VRDCITESSL
960 970 980 990 1000
RSDMCHRSNN SLRDSTEGSK SSETLSREPV TLHAGDREDP SGCFTFTSAA
1010 1020 1030 1040 1050
SPSVKNSASR SFNSSPKKSP VHSLLTSSVE GSIGSTSQYR SAKPIHSSDS
1060 1070 1080 1090 1100
VKDSQSPPIE TTGKTCRKLQ NRLESLQTLV EDLQLKNQAM SSMIRNQEKR
1110
IQKVKDQEKM LLK
Length:1,113
Mass (Da):127,140
Last modified:March 18, 2008 - v2
Checksum:iD56CE9B93AFAF24D
GO
Isoform 2 (identifier: Q5M9N0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-947: Missing.

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):60,601
Checksum:i37E4E416B8056A36
GO
Isoform 3 (identifier: Q5M9N0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-406: TEELEKQLVL...KEQNKRLWDR → ENLQNSPLRI...AEFCIKKVMI
     407-1113: Missing.

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):46,948
Checksum:iC77829BF0BDB9072
GO

Sequence cautioni

The sequence BAC05347 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05359 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BC035224 differs from that shown. Reason: Frameshift at position 204.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039909232E → D. Corresponds to variant dbSNP:rs17001889Ensembl.1
Natural variantiVAR_039910297I → V. Corresponds to variant dbSNP:rs17001885Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032390344 – 406TEELE…RLWDR → ENLQNSPLRIWTSRSCHYWL CRFGFTLNFRFLTTKISPDV DSAFIFTTLKAVGAEFCIKK VMI in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_032391368 – 947Missing in isoform 2. 1 PublicationAdd BLAST580
Alternative sequenceiVSP_032392407 – 1113Missing in isoform 3. 1 PublicationAdd BLAST707

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034139 Genomic DNA No translation available.
AC096743 Genomic DNA No translation available.
BC035224 mRNA No translation available.
BC086869 mRNA Translation: AAH86869.1
AK098600 mRNA Translation: BAC05347.1 Different initiation.
AK098636 mRNA Translation: BAC05359.1 Different initiation.
CCDSiCCDS43242.1 [Q5M9N0-1]
RefSeqiNP_001036249.1, NM_001042784.1 [Q5M9N0-1]
XP_005263031.1, XM_005262974.4 [Q5M9N0-1]
UniGeneiHs.529680

Genome annotation databases

EnsembliENST00000388914; ENSP00000373566; ENSG00000163749 [Q5M9N0-1]
ENST00000434846; ENSP00000401742; ENSG00000163749 [Q5M9N0-3]
GeneIDi339965
KEGGihsa:339965
UCSCiuc003hkb.5 human [Q5M9N0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD158_HUMAN
AccessioniPrimary (citable) accession number: Q5M9N0
Secondary accession number(s): Q8IYQ1, Q8N7D4, Q8N7E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: February 28, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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