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Protein

Coiled-coil domain-containing protein 158

Gene

CCDC158

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 158
Gene namesi
Name:CCDC158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26374. CCDC158.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163749.
PharmGKBiPA164717707.

Polymorphism and mutation databases

BioMutaiCCDC158.
DMDMi172045891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257601 – 1113Coiled-coil domain-containing protein 158Add BLAST1113

Proteomic databases

EPDiQ5M9N0.
MaxQBiQ5M9N0.
PaxDbiQ5M9N0.
PeptideAtlasiQ5M9N0.
PRIDEiQ5M9N0.

PTM databases

iPTMnetiQ5M9N0.
PhosphoSitePlusiQ5M9N0.

Expressioni

Gene expression databases

BgeeiENSG00000163749.
GenevisibleiQ5M9N0. HS.

Organism-specific databases

HPAiHPA026637.

Interactioni

Protein-protein interaction databases

BioGridi130969. 11 interactors.
DIPiDIP-47314N.
IntActiQ5M9N0. 9 interactors.
MINTiMINT-1458464.
STRINGi9606.ENSP00000373566.

Structurei

3D structure databases

ProteinModelPortaliQ5M9N0.
SMRiQ5M9N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 183Sequence analysisAdd BLAST112
Coiled coili243 – 833Sequence analysisAdd BLAST591
Coiled coili1061 – 1113Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 28Poly-Ser4
Compositional biasi948 – 1056Ser-richAdd BLAST109

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE3R. Eukaryota.
ENOG41102XW. LUCA.
GeneTreeiENSGT00390000013339.
HOGENOMiHOG000111475.
InParanoidiQ5M9N0.
OMAiFMSSIRG.
OrthoDBiEOG091G01IP.
PhylomeDBiQ5M9N0.
TreeFamiTF337019.

Family and domain databases

InterProiIPR031809. CCDC158.
[Graphical view]
PfamiPF15921. CCDC158. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5M9N0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESKAWESNN EDLLSSSGVT SNGGSSSSFF VSSIRGTIIE NTSSAGTLTQ
60 70 80 90 100
VPFFPKYEVE LDSPRKIIPS PGKEHFERVL EEYSHQVKDL QRRLNESNEL
110 120 130 140 150
HEKQKFYLRQ SVIDLQTKLQ EMQMERDAMA DIRRRESQSQ EDLRNQLQNT
160 170 180 190 200
VHELEAAKCL KEDMLKDSNT QIEQLRKMML SHEGVLQEIR SILVDFEEAS
210 220 230 240 250
GKKICEHDSM STLHFRSLGS AISKILRELD TEISYLKGRI FPVEDQLEAL
260 270 280 290 300
KSESQNKIEL LLQQHQDRIE QLISEHEVEI TGLTEKASSA RSQANSIQSQ
310 320 330 340 350
MEIIQEQARN QNSMYMRQLS DLESTVSQLR SELREAKRMY EDKTEELEKQ
360 370 380 390 400
LVLANSELTE ARTERDQFSQ ESGNLDDQLQ KLLADLHKRE KELSLEKEQN
410 420 430 440 450
KRLWDRDTGN SITIDHLRRE LDNRNMEVQR LEALLKALKS ECQGQMERQM
460 470 480 490 500
AAIQGKNESL EKVSSLTAQL ESTKEMLRKV VEELTAKKMT LESSERTISD
510 520 530 540 550
LTTSLQEKER AIEATNAEIT KLRSRVDLKL QELQHLKNEG DHLRNVQTEC
560 570 580 590 600
EALKLQMTEK DKVIEILRQQ IENMTQLVGQ HGRTAGAMQV EKAQLEKEIN
610 620 630 640 650
DRRMELKELK ILKDKKDAKI RELEARVSDL ELEKVKLVNA GSERLRAVKD
660 670 680 690 700
IKQERDQLLN EVKTSRSELN NLSEEYEVLK RNFRNKSEEM EMTTNKLKMQ
710 720 730 740 750
LKSAQSELEQ TRNTLKSMEG SDGHAMKVAM GMQKQITAKR GQIDALQSKI
760 770 780 790 800
QFLEEAMTNA NKEKHFLKEE KSKLSQELST VATEKNKMAG ELEVLRSQER
810 820 830 840 850
RLKEKVTNME VALDKASLQF AECQDIIQRQ EQESVRLKLQ HTLDIKELQG
860 870 880 890 900
PGYTSNSSLK PRLLQPASVT RSHSNVPSSQ STASFLSHHS TKANTLKEDP
910 920 930 940 950
TRDLKQLLQE LRSVINEEPA VSLSKTEEDG RTSLGALEDR VRDCITESSL
960 970 980 990 1000
RSDMCHRSNN SLRDSTEGSK SSETLSREPV TLHAGDREDP SGCFTFTSAA
1010 1020 1030 1040 1050
SPSVKNSASR SFNSSPKKSP VHSLLTSSVE GSIGSTSQYR SAKPIHSSDS
1060 1070 1080 1090 1100
VKDSQSPPIE TTGKTCRKLQ NRLESLQTLV EDLQLKNQAM SSMIRNQEKR
1110
IQKVKDQEKM LLK
Length:1,113
Mass (Da):127,140
Last modified:March 18, 2008 - v2
Checksum:iD56CE9B93AFAF24D
GO
Isoform 2 (identifier: Q5M9N0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-947: Missing.

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):60,601
Checksum:i37E4E416B8056A36
GO
Isoform 3 (identifier: Q5M9N0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-406: TEELEKQLVL...KEQNKRLWDR → ENLQNSPLRI...AEFCIKKVMI
     407-1113: Missing.

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):46,948
Checksum:iC77829BF0BDB9072
GO

Sequence cautioni

The sequence BAC05347 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05359 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BC035224 differs from that shown. Reason: Frameshift at position 204.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039909232E → D.Corresponds to variant rs17001889dbSNPEnsembl.1
Natural variantiVAR_039910297I → V.Corresponds to variant rs17001885dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032390344 – 406TEELE…RLWDR → ENLQNSPLRIWTSRSCHYWL CRFGFTLNFRFLTTKISPDV DSAFIFTTLKAVGAEFCIKK VMI in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_032391368 – 947Missing in isoform 2. 1 PublicationAdd BLAST580
Alternative sequenceiVSP_032392407 – 1113Missing in isoform 3. 1 PublicationAdd BLAST707

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034139 Genomic DNA. No translation available.
AC096743 Genomic DNA. No translation available.
BC035224 mRNA. No translation available.
BC086869 mRNA. Translation: AAH86869.1.
AK098600 mRNA. Translation: BAC05347.1. Different initiation.
AK098636 mRNA. Translation: BAC05359.1. Different initiation.
CCDSiCCDS43242.1. [Q5M9N0-1]
RefSeqiNP_001036249.1. NM_001042784.1. [Q5M9N0-1]
XP_005263031.1. XM_005262974.4. [Q5M9N0-1]
UniGeneiHs.529680.

Genome annotation databases

EnsembliENST00000388914; ENSP00000373566; ENSG00000163749. [Q5M9N0-1]
ENST00000434846; ENSP00000401742; ENSG00000163749. [Q5M9N0-3]
GeneIDi339965.
KEGGihsa:339965.
UCSCiuc003hkb.5. human. [Q5M9N0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034139 Genomic DNA. No translation available.
AC096743 Genomic DNA. No translation available.
BC035224 mRNA. No translation available.
BC086869 mRNA. Translation: AAH86869.1.
AK098600 mRNA. Translation: BAC05347.1. Different initiation.
AK098636 mRNA. Translation: BAC05359.1. Different initiation.
CCDSiCCDS43242.1. [Q5M9N0-1]
RefSeqiNP_001036249.1. NM_001042784.1. [Q5M9N0-1]
XP_005263031.1. XM_005262974.4. [Q5M9N0-1]
UniGeneiHs.529680.

3D structure databases

ProteinModelPortaliQ5M9N0.
SMRiQ5M9N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130969. 11 interactors.
DIPiDIP-47314N.
IntActiQ5M9N0. 9 interactors.
MINTiMINT-1458464.
STRINGi9606.ENSP00000373566.

PTM databases

iPTMnetiQ5M9N0.
PhosphoSitePlusiQ5M9N0.

Polymorphism and mutation databases

BioMutaiCCDC158.
DMDMi172045891.

Proteomic databases

EPDiQ5M9N0.
MaxQBiQ5M9N0.
PaxDbiQ5M9N0.
PeptideAtlasiQ5M9N0.
PRIDEiQ5M9N0.

Protocols and materials databases

DNASUi339965.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388914; ENSP00000373566; ENSG00000163749. [Q5M9N0-1]
ENST00000434846; ENSP00000401742; ENSG00000163749. [Q5M9N0-3]
GeneIDi339965.
KEGGihsa:339965.
UCSCiuc003hkb.5. human. [Q5M9N0-1]

Organism-specific databases

CTDi339965.
GeneCardsiCCDC158.
HGNCiHGNC:26374. CCDC158.
HPAiHPA026637.
neXtProtiNX_Q5M9N0.
OpenTargetsiENSG00000163749.
PharmGKBiPA164717707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE3R. Eukaryota.
ENOG41102XW. LUCA.
GeneTreeiENSGT00390000013339.
HOGENOMiHOG000111475.
InParanoidiQ5M9N0.
OMAiFMSSIRG.
OrthoDBiEOG091G01IP.
PhylomeDBiQ5M9N0.
TreeFamiTF337019.

Miscellaneous databases

GenomeRNAii339965.
PROiQ5M9N0.

Gene expression databases

BgeeiENSG00000163749.
GenevisibleiQ5M9N0. HS.

Family and domain databases

InterProiIPR031809. CCDC158.
[Graphical view]
PfamiPF15921. CCDC158. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD158_HUMAN
AccessioniPrimary (citable) accession number: Q5M9N0
Secondary accession number(s): Q8IYQ1, Q8N7D4, Q8N7E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.