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Protein

Transthyretin

Gene

Ttr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Thyroid hormoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
TransthyretinUniRule annotation
Gene namesi
Name:TtrImported
ORF Names:mCG_123157Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98865. Ttr.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500999876521 – 147TransthyretinUniRule annotationAdd BLAST127

Expressioni

Gene expression databases

BgeeiENSMUSG00000061808.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074783.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 147TR_THYInterPro annotationAdd BLAST121

Sequence similaritiesi

Belongs to the transthyretin family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
HOVERGENiHBG000285.
KOiK20731.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiView protein in InterPro
IPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
PANTHERiPTHR10395. PTHR10395. 1 hit.
PTHR10395:SF19. PTHR10395:SF19. 1 hit.
PfamiView protein in Pfam
PF00576. Transthyretin. 1 hit.
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiView protein in SMART
SM00095. TR_THY. 1 hit.
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiView protein in PROSITE
PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M9K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRLFLLC LAGLVFVSEA GPAGAGESKC PLMVKVLDAV RGSPAVDVAV
60 70 80 90 100
KVFKKTSEGS WEPFASGKTA ESGELHGLTT DEKFVEGVYR VELDTKSYWK
110 120 130 140
TLGISPFHEF ADVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN
Length:147
Mass (Da):15,776
Last modified:May 10, 2005 - v1
Checksum:i9803CCC3024BA911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086926 mRNA. Translation: AAH86926.1.
AK050155 mRNA. Translation: BAC34098.1.
AK075588 mRNA. Translation: BAC35839.1.
CH466557 Genomic DNA. Translation: EDK96952.1.
RefSeqiNP_038725.1. NM_013697.5.
UniGeneiMm.2108.

Genome annotation databases

GeneIDi22139.
KEGGimmu:22139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086926 mRNA. Translation: AAH86926.1.
AK050155 mRNA. Translation: BAC34098.1.
AK075588 mRNA. Translation: BAC35839.1.
CH466557 Genomic DNA. Translation: EDK96952.1.
RefSeqiNP_038725.1. NM_013697.5.
UniGeneiMm.2108.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22139.
KEGGimmu:22139.

Organism-specific databases

CTDi7276.
MGIiMGI:98865. Ttr.

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
HOVERGENiHBG000285.
KOiK20731.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.

Miscellaneous databases

ChiTaRSiTtr. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061808.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiView protein in InterPro
IPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
PANTHERiPTHR10395. PTHR10395. 1 hit.
PTHR10395:SF19. PTHR10395:SF19. 1 hit.
PfamiView protein in Pfam
PF00576. Transthyretin. 1 hit.
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiView protein in SMART
SM00095. TR_THY. 1 hit.
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiView protein in PROSITE
PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5M9K1_MOUSE
AccessioniPrimary (citable) accession number: Q5M9K1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 10, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.