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Protein

Transthyretin

Gene

Ttr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Thyroid hormoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
TransthyretinUniRule annotation
Gene namesi
Name:TtrImported
ORF Names:mCG_123157Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98865 Ttr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501420589521 – 147TransthyretinUniRule annotationAdd BLAST127

Proteomic databases

MaxQBiQ5M9K1

Expressioni

Gene expression databases

BgeeiENSMUSG00000061808
ExpressionAtlasiQ5M9K1 baseline and differential

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5M9K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 147TR_THYInterPro annotationAdd BLAST121

Sequence similaritiesi

Belongs to the transthyretin family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3006 Eukaryota
COG2351 LUCA
HOVERGENiHBG000285
KOiK20731
OMAiHRHYTIA
OrthoDBiEOG091G0VSV

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR023418 Thyroxine_BS
IPR030178 Transthyretin
IPR000895 Transthyretin/HIU_hydrolase
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
IPR023419 Transthyretin_CS
PANTHERiPTHR10395 PTHR10395, 1 hit
PTHR10395:SF12 PTHR10395:SF12, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
PRINTSiPR00189 TRNSTHYRETIN
SMARTiView protein in SMART
SM00095 TR_THY, 1 hit
SUPFAMiSSF49472 SSF49472, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit
PS00769 TRANSTHYRETIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M9K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRLFLLC LAGLVFVSEA GPAGAGESKC PLMVKVLDAV RGSPAVDVAV
60 70 80 90 100
KVFKKTSEGS WEPFASGKTA ESGELHGLTT DEKFVEGVYR VELDTKSYWK
110 120 130 140
TLGISPFHEF ADVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN
Length:147
Mass (Da):15,776
Last modified:May 10, 2005 - v1
Checksum:i9803CCC3024BA911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086926 mRNA Translation: AAH86926.1
AK050155 mRNA Translation: BAC34098.1
AK075588 mRNA Translation: BAC35839.1
CH466557 Genomic DNA Translation: EDK96952.1
RefSeqiNP_038725.1, NM_013697.5
UniGeneiMm.2108

Genome annotation databases

GeneIDi22139
KEGGimmu:22139

Similar proteinsi

Entry informationi

Entry nameiQ5M9K1_MOUSE
AccessioniPrimary (citable) accession number: Q5M9K1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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