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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

Uqcrh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • ubiquinol-cytochrome-c reductase activity Source: InterPro

GO - Biological processi

  • mitochondrial electron transport, ubiquinol to cytochrome c Source: RGD
  • protein heterooligomerization Source: RGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:Uqcrh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305987. Uqcrh.

Subcellular locationi

  • Mitochondrion inner membrane By similarity

GO - Cellular componenti

  • mitochondrial respiratory chain complex III Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313MitochondrionBy similarityAdd
BLAST
Chaini14 – 8976Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000035993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 79By similarity
Modified residuei40 – 401N6-acetyllysineBy similarity
Disulfide bondi51 ↔ 65By similarity
Modified residuei83 – 831N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiQ5M9I5.
PRIDEiQ5M9I5.

PTM databases

iPTMnetiQ5M9I5.
PhosphoSiteiQ5M9I5.

Expressioni

Gene expression databases

GenevisibleiQ5M9I5. RN.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi265934. 1 interaction.
STRINGi10116.ENSRNOP00000016751.

Structurei

3D structure databases

ProteinModelPortaliQ5M9I5.
SMRiQ5M9I5. Positions 14-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 236Poly-Glu

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiQ5M9I5.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG7PK92F.
PhylomeDBiQ5M9I5.
TreeFamiTF105036.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M9I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDERKML TGSGDPKEEE EEELVDPLTT VREHCEQLEK CVKARERLES
60 70 80
CDRRVSSRSQ TEEDCTEELF DFLHARDHCV AHKLFKSLK
Length:89
Mass (Da):10,424
Last modified:February 1, 2005 - v1
Checksum:i96FA0CCBCE312A28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086954 mRNA. Translation: AAH86954.1.
RefSeqiNP_001009480.1. NM_001009480.1.
UniGeneiRn.7401.

Genome annotation databases

EnsembliENSRNOT00000016751; ENSRNOP00000016751; ENSRNOG00000012550.
GeneIDi366448.
KEGGirno:366448.
UCSCiRGD:1305987. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086954 mRNA. Translation: AAH86954.1.
RefSeqiNP_001009480.1. NM_001009480.1.
UniGeneiRn.7401.

3D structure databases

ProteinModelPortaliQ5M9I5.
SMRiQ5M9I5. Positions 14-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi265934. 1 interaction.
STRINGi10116.ENSRNOP00000016751.

PTM databases

iPTMnetiQ5M9I5.
PhosphoSiteiQ5M9I5.

Proteomic databases

PaxDbiQ5M9I5.
PRIDEiQ5M9I5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016751; ENSRNOP00000016751; ENSRNOG00000012550.
GeneIDi366448.
KEGGirno:366448.
UCSCiRGD:1305987. rat.

Organism-specific databases

CTDi7388.
RGDi1305987. Uqcrh.

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiQ5M9I5.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG7PK92F.
PhylomeDBiQ5M9I5.
TreeFamiTF105036.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Miscellaneous databases

PROiQ5M9I5.

Gene expression databases

GenevisibleiQ5M9I5. RN.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiQCR6_RAT
AccessioniPrimary (citable) accession number: Q5M9I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: February 1, 2005
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.