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Protein

Leucine-rich repeat-containing protein 41

Gene

Lrrc41

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 41
Gene namesi
Name:Lrrc41
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311221. Lrrc41.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Leucine-rich repeat-containing protein 41PRO_0000292659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551PhosphoserineBy similarity
Modified residuei276 – 2761PhosphoserineBy similarity
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei327 – 3271PhosphothreonineBy similarity
Modified residuei369 – 3691PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5M9H1.
PRIDEiQ5M9H1.

PTM databases

iPTMnetiQ5M9H1.
PhosphoSiteiQ5M9H1.

Expressioni

Gene expression databases

GenevisibleiQ5M9H1. RN.

Interactioni

Subunit structurei

Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi263543. 2 interactions.
STRINGi10116.ENSRNOP00000018506.

Structurei

3D structure databases

ProteinModelPortaliQ5M9H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati483 – 50321LRR 1Add
BLAST
Repeati514 – 52613LRR 2Add
BLAST
Repeati527 – 55125LRR 3Add
BLAST
Repeati609 – 63123LRR 4Add
BLAST
Repeati632 – 65524LRR 5Add
BLAST
Repeati697 – 72428LRR 6Add
BLAST
Repeati727 – 74822LRR 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni45 – 5410Interaction with Elongin BC complexBy similarity

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].By similarity

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHRR. Eukaryota.
ENOG410YFW5. LUCA.
GeneTreeiENSGT00390000015908.
HOGENOMiHOG000013094.
HOVERGENiHBG102701.
InParanoidiQ5M9H1.
KOiK10347.
OMAiFADYISV.
OrthoDBiEOG7060QB.
PhylomeDBiQ5M9H1.
TreeFamiTF335481.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR026137. Leu_rpt_41.
[Graphical view]
PANTHERiPTHR15354. PTHR15354. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M9H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP SAPPALFELC
60 70 80 90 100
GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ
110 120 130 140 150
AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDKRLC
160 170 180 190 200
DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF
210 220 230 240 250
RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS
260 270 280 290 300
AGFWQPGPGS LPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
310 320 330 340 350
LMATRRKSEV KQVPRALPTS RVTRRSTQES LTIGGTDSKR ELYPPATSYE
360 370 380 390 400
ASGTKQPSSA PTAASSSTSS KRAPASSVSQ PKPLKRFKRA TGKKGPRTRQ
410 420 430 440 450
GSGAESEDLY DFVFIVAGEK EDGEEMEIGE VACGALDGSD PSCLGLPALE
460 470 480 490 500
ASQRFRSIST LELFTVPLST EAALTLCHLL SSWVSLESLT LSYNGLGSNI
510 520 530 540 550
FRLLDSLRVL SGQAGCRLRA LHLSDLFSPL PILELTRAIV RALPLLRVLS
560 570 580 590 600
IRVDHPSQRD NPAVPENAGP PGHIIGDEEI PENCLEQLEM GFPRGAQPAP
610 620 630 640 650
LLCSVLKASG SLQQLSLDSA TFASPQDFGL VLQTLKEYNL SLKRLSFHDM
660 670 680 690 700
NLADCQSEVL FLLKNLTLQE ITFSFCRLFE KRPAQFLPEM VAAMKGNSTL
710 720 730 740 750
KGLRLPGNRL GNAGLLALAD VFSEDSSSSL CQLDISSNCI KPDGLLEFAK
760 770 780 790 800
RLERWGRGAF GHLRLFQNWL DQDAVTAREA IRRLRATCHV VSDSWDSTQA

FADYVSTM
Length:808
Mass (Da):88,508
Last modified:February 1, 2005 - v1
Checksum:iB2634B486F4207DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087037 mRNA. Translation: AAH87037.1.
RefSeqiNP_001009710.1. NM_001009710.1.
UniGeneiRn.1938.

Genome annotation databases

EnsembliENSRNOT00000018506; ENSRNOP00000018506; ENSRNOG00000013642.
GeneIDi362566.
KEGGirno:362566.
UCSCiRGD:1311221. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087037 mRNA. Translation: AAH87037.1.
RefSeqiNP_001009710.1. NM_001009710.1.
UniGeneiRn.1938.

3D structure databases

ProteinModelPortaliQ5M9H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263543. 2 interactions.
STRINGi10116.ENSRNOP00000018506.

PTM databases

iPTMnetiQ5M9H1.
PhosphoSiteiQ5M9H1.

Proteomic databases

PaxDbiQ5M9H1.
PRIDEiQ5M9H1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018506; ENSRNOP00000018506; ENSRNOG00000013642.
GeneIDi362566.
KEGGirno:362566.
UCSCiRGD:1311221. rat.

Organism-specific databases

CTDi10489.
RGDi1311221. Lrrc41.

Phylogenomic databases

eggNOGiENOG410IHRR. Eukaryota.
ENOG410YFW5. LUCA.
GeneTreeiENSGT00390000015908.
HOGENOMiHOG000013094.
HOVERGENiHBG102701.
InParanoidiQ5M9H1.
KOiK10347.
OMAiFADYISV.
OrthoDBiEOG7060QB.
PhylomeDBiQ5M9H1.
TreeFamiTF335481.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ5M9H1.

Gene expression databases

GenevisibleiQ5M9H1. RN.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR026137. Leu_rpt_41.
[Graphical view]
PANTHERiPTHR15354. PTHR15354. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiLRC41_RAT
AccessioniPrimary (citable) accession number: Q5M9H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 1, 2005
Last modified: July 6, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.