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Q5M9G0

- DCTD_RAT

UniProt

Q5M9G0 - DCTD_RAT

Protein

Deoxycytidylate deaminase

Gene

Dctd

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Supplies the nucleotide substrate for thymidylate synthetase.By similarity

    Catalytic activityi

    dCMP + H2O = dUMP + NH3.

    Cofactori

    Zinc.By similarity

    Enzyme regulationi

    Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Zinc; catalyticBy similarity
    Active sitei86 – 861Proton donorBy similarity
    Metal bindingi110 – 1101Zinc; catalyticBy similarity
    Metal bindingi113 – 1131Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. dCMP deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. nucleotide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_212687. Pyrimidine biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxycytidylate deaminase (EC:3.5.4.12)
    Alternative name(s):
    dCMP deaminase
    Gene namesi
    Name:Dctd
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1359671. Dctd.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Deoxycytidylate deaminasePRO_0000171694Add
    BLAST

    Proteomic databases

    PRIDEiQ5M9G0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5M9G0.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000017670.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M9G0.
    SMRiQ5M9G0. Positions 12-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2131.
    HOGENOMiHOG000015715.
    HOVERGENiHBG025823.
    InParanoidiQ5M9G0.
    KOiK01493.
    PhylomeDBiQ5M9G0.
    TreeFamiTF105971.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view]
    PANTHERiPTHR11086. PTHR11086. 1 hit.
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5M9G0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG    50
    IGYNGMPNGC SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG 100
    CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSEETTA ARLLFKLAGV 150
    TFRKFTPKYS KIVIDFDSIN SRPSQKPQ 178
    Length:178
    Mass (Da):20,059
    Last modified:February 1, 2005 - v1
    Checksum:iA53ED5C676965029
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087138 mRNA. Translation: AAH87138.1.
    RefSeqiNP_001013904.2. NM_001013882.2.
    NP_001154984.1. NM_001161512.1.
    UniGeneiRn.105816.

    Genome annotation databases

    GeneIDi290741.
    KEGGirno:290741.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087138 mRNA. Translation: AAH87138.1 .
    RefSeqi NP_001013904.2. NM_001013882.2.
    NP_001154984.1. NM_001161512.1.
    UniGenei Rn.105816.

    3D structure databases

    ProteinModelPortali Q5M9G0.
    SMRi Q5M9G0. Positions 12-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000017670.

    Proteomic databases

    PRIDEi Q5M9G0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 290741.
    KEGGi rno:290741.

    Organism-specific databases

    CTDi 1635.
    RGDi 1359671. Dctd.

    Phylogenomic databases

    eggNOGi COG2131.
    HOGENOMi HOG000015715.
    HOVERGENi HBG025823.
    InParanoidi Q5M9G0.
    KOi K01493.
    PhylomeDBi Q5M9G0.
    TreeFami TF105971.

    Enzyme and pathway databases

    Reactomei REACT_212687. Pyrimidine biosynthesis.

    Miscellaneous databases

    NextBioi 631565.
    PROi Q5M9G0.

    Gene expression databases

    Genevestigatori Q5M9G0.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view ]
    PANTHERi PTHR11086. PTHR11086. 1 hit.
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiDCTD_RAT
    AccessioniPrimary (citable) accession number: Q5M9G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3