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Q5M9G0

- DCTD_RAT

UniProt

Q5M9G0 - DCTD_RAT

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Protein

Deoxycytidylate deaminase

Gene

Dctd

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarity

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Zinc; catalyticBy similarity
Active sitei86 – 861Proton donorBy similarity
Metal bindingi110 – 1101Zinc; catalyticBy similarity
Metal bindingi113 – 1131Zinc; catalyticBy similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. nucleotide biosynthetic process Source: UniProtKB-KW
  2. pyrimidine nucleotide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_212687. Pyrimidine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:Dctd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1359671. Dctd.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Deoxycytidylate deaminasePRO_0000171694Add
BLAST

Proteomic databases

PRIDEiQ5M9G0.

Expressioni

Gene expression databases

ExpressionAtlasiQ5M9G0. baseline and differential.
GenevestigatoriQ5M9G0.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017670.

Structurei

3D structure databases

ProteinModelPortaliQ5M9G0.
SMRiQ5M9G0. Positions 12-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2131.
HOGENOMiHOG000015715.
HOVERGENiHBG025823.
InParanoidiQ5M9G0.
KOiK01493.
PhylomeDBiQ5M9G0.
TreeFamiTF105971.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M9G0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG
60 70 80 90 100
IGYNGMPNGC SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG
110 120 130 140 150
CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSEETTA ARLLFKLAGV
160 170
TFRKFTPKYS KIVIDFDSIN SRPSQKPQ
Length:178
Mass (Da):20,059
Last modified:February 1, 2005 - v1
Checksum:iA53ED5C676965029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087138 mRNA. Translation: AAH87138.1.
RefSeqiNP_001013904.2. NM_001013882.2.
NP_001154984.1. NM_001161512.1.
UniGeneiRn.105816.

Genome annotation databases

GeneIDi290741.
KEGGirno:290741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087138 mRNA. Translation: AAH87138.1 .
RefSeqi NP_001013904.2. NM_001013882.2.
NP_001154984.1. NM_001161512.1.
UniGenei Rn.105816.

3D structure databases

ProteinModelPortali Q5M9G0.
SMRi Q5M9G0. Positions 12-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017670.

Proteomic databases

PRIDEi Q5M9G0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 290741.
KEGGi rno:290741.

Organism-specific databases

CTDi 1635.
RGDi 1359671. Dctd.

Phylogenomic databases

eggNOGi COG2131.
HOGENOMi HOG000015715.
HOVERGENi HBG025823.
InParanoidi Q5M9G0.
KOi K01493.
PhylomeDBi Q5M9G0.
TreeFami TF105971.

Enzyme and pathway databases

Reactomei REACT_212687. Pyrimidine biosynthesis.

Miscellaneous databases

NextBioi 631565.
PROi Q5M9G0.

Gene expression databases

ExpressionAtlasi Q5M9G0. baseline and differential.
Genevestigatori Q5M9G0.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view ]
PANTHERi PTHR11086. PTHR11086. 1 hit.
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDCTD_RAT
AccessioniPrimary (citable) accession number: Q5M9G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3