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Protein

N-terminal kinase-like protein

Gene

Scyl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal kinase-like protein
Alternative name(s):
SCY1-like protein 1
Gene namesi
Name:Scyl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307330. Scyl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807N-terminal kinase-like proteinPRO_0000249543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei753 – 7531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5M9F8.
PRIDEiQ5M9F8.

PTM databases

iPTMnetiQ5M9F8.
PhosphoSiteiQ5M9F8.

Expressioni

Gene expression databases

GenevisibleiQ5M9F8. RN.

Interactioni

Subunit structurei

Homooligomer. Interacts with GORAB. Interacts with COPA, COPB1 and COPB2. Interacts with AP2B1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi254397. 2 interactions.
STRINGi10116.ENSRNOP00000030146.

Structurei

3D structure databases

ProteinModelPortaliQ5M9F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 314301Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati350 – 38839HEAT 1Add
BLAST
Repeati389 – 42739HEAT 2Add
BLAST
Repeati507 – 54539HEAT 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni792 – 80716Interacts with COPB1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili756 – 79641Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi589 – 61931Pro-richAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 3 HEAT repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
GeneTreeiENSGT00760000119345.
HOGENOMiHOG000208340.
HOVERGENiHBG082065.
InParanoidiQ5M9F8.
KOiK08876.
OMAiNEVRDGW.
OrthoDBiEOG7RJPQX.
PhylomeDBiQ5M9F8.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M9F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFFARDPVR DFPFELNPEP PEGGPPGPWV LHRGRKKATG SAVSIFVYDV
60 70 80 90 100
KPGAEEQTQV AKAAFKRLKT LRHPNILAYI DGLETEKCLH IVTEAVTPLG
110 120 130 140 150
TYLKARAEAG GLKEQELSWG LHQIVKALSF LVNDCNLIHN NVCMAAVFVD
160 170 180 190 200
KAGEWKLGGL DYMYSAQGNG GGPPNKGIPE LEQYDPPELA DSSSRAVKEK
210 220 230 240 250
WSADMWRLGC LIWEVFNGSL PRATALRNPG KIPKSLVTHY CELVGANPKV
260 270 280 290 300
RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS
310 320 330 340 350
LDSFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI
360 370 380 390 400
IPVVVKMFSS TDRAMRVRLL QQMEQFIQYL DEPTVNTQIF PHVTHGFLDT
410 420 430 440 450
NPAIREQTVK SMLLLAPKLS ETNLNVELLK HFARLQAKDD QGPIRCNTTV
460 470 480 490 500
CLGKIGSYLS ASTRHRVLTS AFSRATKDPF APSRVAGVLG FAATHNLYSM
510 520 530 540 550
DDCAHKILPV LCGLTVDPEK SVRDQAFKTI RSFLSKLESV SEDPTQLAEI
560 570 580 590 600
EKDVHAASSP GTGGAAASWA GWAVTGVSSL TSKLIRTHPT PVPSEAAVPQ
610 620 630 640 650
RPVPEGDPAP APAPASATPA TSGHRETQEE DKDAAEDSAT ADRWDDEDWG
660 670 680 690 700
SLEQEAESVL AQQDDWSTKG QGNRAGQVSH SDHKSLDSHW SSWEVEGSWD
710 720 730 740 750
QGWQEPSSVE PPPEGTRLAS EYNWGGAEPS DKGDPFAALS VRPSTQPRPD
760 770 780 790 800
PDSWGEDNWE GLEAESRQVK AELARKKREE RRREMEAKRA EKKATKGPMK

LGARKLD
Length:807
Mass (Da):89,126
Last modified:February 1, 2005 - v1
Checksum:i4CCB0E6F042BFED6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087141 mRNA. Translation: AAH87141.1.
RefSeqiNP_001011938.1. NM_001011938.1.
UniGeneiRn.143751.

Genome annotation databases

EnsembliENSRNOT00000032387; ENSRNOP00000030146; ENSRNOG00000023668.
GeneIDi293684.
KEGGirno:293684.
UCSCiRGD:1307330. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087141 mRNA. Translation: AAH87141.1.
RefSeqiNP_001011938.1. NM_001011938.1.
UniGeneiRn.143751.

3D structure databases

ProteinModelPortaliQ5M9F8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi254397. 2 interactions.
STRINGi10116.ENSRNOP00000030146.

PTM databases

iPTMnetiQ5M9F8.
PhosphoSiteiQ5M9F8.

Proteomic databases

PaxDbiQ5M9F8.
PRIDEiQ5M9F8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032387; ENSRNOP00000030146; ENSRNOG00000023668.
GeneIDi293684.
KEGGirno:293684.
UCSCiRGD:1307330. rat.

Organism-specific databases

CTDi57410.
RGDi1307330. Scyl1.

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
GeneTreeiENSGT00760000119345.
HOGENOMiHOG000208340.
HOVERGENiHBG082065.
InParanoidiQ5M9F8.
KOiK08876.
OMAiNEVRDGW.
OrthoDBiEOG7RJPQX.
PhylomeDBiQ5M9F8.

Miscellaneous databases

PROiQ5M9F8.

Gene expression databases

GenevisibleiQ5M9F8. RN.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiNTKL_RAT
AccessioniPrimary (citable) accession number: Q5M9F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: February 1, 2005
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.