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Protein

N-terminal kinase-like protein

Gene

Scyl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal kinase-like protein
Alternative name(s):
SCY1-like protein 1
Gene namesi
Name:Scyl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307330. Scyl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495431 – 807N-terminal kinase-like proteinAdd BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei753PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5M9F8.
PRIDEiQ5M9F8.

PTM databases

iPTMnetiQ5M9F8.
PhosphoSitePlusiQ5M9F8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023668.
GenevisibleiQ5M9F8. RN.

Interactioni

Subunit structurei

Homooligomer. Interacts with GORAB. Interacts with COPA, COPB1 and COPB2. Interacts with AP2B1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi254397. 2 interactors.
STRINGi10116.ENSRNOP00000030146.

Structurei

3D structure databases

ProteinModelPortaliQ5M9F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 314Protein kinasePROSITE-ProRule annotationAdd BLAST301
Repeati350 – 388HEAT 1Add BLAST39
Repeati389 – 427HEAT 2Add BLAST39
Repeati507 – 545HEAT 3Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni792 – 807Interaction with COPB1By similarityAdd BLAST16

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili756 – 796Sequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi589 – 619Pro-richAdd BLAST31

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
GeneTreeiENSGT00890000139451.
HOGENOMiHOG000208340.
HOVERGENiHBG082065.
InParanoidiQ5M9F8.
KOiK08876.
OMAiEHESNDT.
OrthoDBiEOG091G02FF.
PhylomeDBiQ5M9F8.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M9F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFFARDPVR DFPFELNPEP PEGGPPGPWV LHRGRKKATG SAVSIFVYDV
60 70 80 90 100
KPGAEEQTQV AKAAFKRLKT LRHPNILAYI DGLETEKCLH IVTEAVTPLG
110 120 130 140 150
TYLKARAEAG GLKEQELSWG LHQIVKALSF LVNDCNLIHN NVCMAAVFVD
160 170 180 190 200
KAGEWKLGGL DYMYSAQGNG GGPPNKGIPE LEQYDPPELA DSSSRAVKEK
210 220 230 240 250
WSADMWRLGC LIWEVFNGSL PRATALRNPG KIPKSLVTHY CELVGANPKV
260 270 280 290 300
RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS
310 320 330 340 350
LDSFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI
360 370 380 390 400
IPVVVKMFSS TDRAMRVRLL QQMEQFIQYL DEPTVNTQIF PHVTHGFLDT
410 420 430 440 450
NPAIREQTVK SMLLLAPKLS ETNLNVELLK HFARLQAKDD QGPIRCNTTV
460 470 480 490 500
CLGKIGSYLS ASTRHRVLTS AFSRATKDPF APSRVAGVLG FAATHNLYSM
510 520 530 540 550
DDCAHKILPV LCGLTVDPEK SVRDQAFKTI RSFLSKLESV SEDPTQLAEI
560 570 580 590 600
EKDVHAASSP GTGGAAASWA GWAVTGVSSL TSKLIRTHPT PVPSEAAVPQ
610 620 630 640 650
RPVPEGDPAP APAPASATPA TSGHRETQEE DKDAAEDSAT ADRWDDEDWG
660 670 680 690 700
SLEQEAESVL AQQDDWSTKG QGNRAGQVSH SDHKSLDSHW SSWEVEGSWD
710 720 730 740 750
QGWQEPSSVE PPPEGTRLAS EYNWGGAEPS DKGDPFAALS VRPSTQPRPD
760 770 780 790 800
PDSWGEDNWE GLEAESRQVK AELARKKREE RRREMEAKRA EKKATKGPMK

LGARKLD
Length:807
Mass (Da):89,126
Last modified:February 1, 2005 - v1
Checksum:i4CCB0E6F042BFED6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087141 mRNA. Translation: AAH87141.1.
RefSeqiNP_001011938.1. NM_001011938.1.
UniGeneiRn.143751.

Genome annotation databases

EnsembliENSRNOT00000032387; ENSRNOP00000030146; ENSRNOG00000023668.
GeneIDi293684.
KEGGirno:293684.
UCSCiRGD:1307330. rat.

Similar proteinsi

Entry informationi

Entry nameiSCYL1_RAT
AccessioniPrimary (citable) accession number: Q5M9F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: February 1, 2005
Last modified: September 27, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families