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Q5M981 (UB12B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 12-B

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 12-B
Ubiquitin thioesterase 12-B
Ubiquitin-specific-processing protease 12-B
Gene names
Name:usp12-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family. USP12/USP46 subfamily.

Contains 1 USP domain.

Sequence caution

The sequence AAH87530.1 differs from that shown. Reason: Conflict that suppressed the initiatory methionine.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Ubiquitin carboxyl-terminal hydrolase 12-B
PRO_0000378994

Regions

Domain39 – 369331USP

Sites

Active site481Nucleophile By similarity
Active site3171Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M981 [UniParc].

Last modified July 7, 2009. Version 2.
Checksum: D0A8CEF5992110D8

FASTA37042,922
        10         20         30         40         50         60 
MEILMTVSRI ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 

        70         80         90        100        110        120 
RPFREKVLAY KSQPRKKENL LTCLSDLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY 

       130        140        150        160        170        180 
MQQDAHEFLN YLLNTIADIL QEERKQEKQN GRIPNGNIDN ENNNNTPDPT WVHEIFQGTL 

       190        200        210        220        230        240 
TNETRCLTCE TISSKDEDFL DLSVDVEQNT SITHCLRGFS NTETLCSEYK YYCEECRSKQ 

       250        260        270        280        290        300 
EAHKRMKVKK LPMILALHLK RFKYMDQLHR YTKLSYRVVF PLELRLFNTS GDATNPDRMY 

       310        320        330        340        350        360 
DLVAVVVHCG SGPNRGHYIA IVKSHDFWLL FDDDIVEKID AQAIEEFYGL TSDISKNSES 

       370 
GYILFYQSRD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC087530 mRNA. Translation: AAH87530.1. Sequence problems.
UniGeneXl.49982.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6252498. usp12.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUB12B_XENLA
AccessionPrimary (citable) accession number: Q5M981
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 7, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries