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Protein

N-acylneuraminate-9-phosphatase

Gene

Nanp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Inhibited by vanadate and calcium.1 Publication

Pathwayi: N-acetylneuraminate biosynthesis

This protein is involved in the pathway N-acetylneuraminate biosynthesis, which is part of Amino-sugar metabolism.
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate biosynthesis and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateBy similarity1

GO - Molecular functioni

  • N-acylneuraminate-9-phosphatase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMagnesium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14517.
ReactomeiR-RNO-4085001. Sialic acid metabolism.
SABIO-RKiQ5M969.
UniPathwayiUPA00630.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylneuraminate-9-phosphatase (EC:3.1.3.29)
Alternative name(s):
Haloacid dehalogenase-like hydrolase domain-containing protein 4
Neu5Ac-9-Pase
Gene namesi
Name:NanpBy similarity
Synonyms:Hdhd4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1306009. Nanp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333791 – 248N-acylneuraminate-9-phosphataseAdd BLAST248

Proteomic databases

PaxDbiQ5M969.
PRIDEiQ5M969.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008307.
GenevisibleiQ5M969. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011315.

Structurei

3D structure databases

ProteinModelPortaliQ5M969.
SMRiQ5M969.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 14Substrate bindingBy similarity3
Regioni131 – 132Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3085. Eukaryota.
COG1011. LUCA.
GeneTreeiENSGT00390000003094.
HOGENOMiHOG000248345.
HOVERGENiHBG051895.
InParanoidiQ5M969.
KOiK01097.
OMAiPQETHDT.
OrthoDBiEOG091G0G6E.
PhylomeDBiQ5M969.
TreeFamiTF324589.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR036412. HAD-like_sf.
IPR006439. HAD-SF_hydro_IA.
IPR011950. HAD-SF_hydro_IA_CTE7.
IPR023214. HAD_sf.
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02253. CTE7. 1 hit.
TIGR01549. HAD-SF-IA-v1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5M969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSRVRAVF FDLDNTLIDT AGASRRGMLE VIKLLQSKYH YKEEAEVICD
60 70 80 90 100
KVQVKLSKEC FHPYSTCITD VRTSHWEEAI QETKGGADNR KLAEECYFLW
110 120 130 140 150
KSTRLQHMTL EEDVKAMLTE LRKEVRLLLL TNGDRQTQRE KIEACACQSY
160 170 180 190 200
FDAIVVGGEQ KEEKPAPSIF YHCCDLLGVQ PGDCVMVGDT LETDIQGGLN
210 220 230 240
AGLKATVWIN KSGGVPLTSS PMPHYMVSSV LELPALLQSI DCKVSMSV
Length:248
Mass (Da):27,741
Last modified:February 1, 2005 - v1
Checksum:i7ABF6063C67BF1AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087587 mRNA. Translation: AAH87587.1.
RefSeqiNP_001009409.1. NM_001009409.1.
UniGeneiRn.210573.

Genome annotation databases

EnsembliENSRNOT00000011315; ENSRNOP00000011315; ENSRNOG00000008307.
GeneIDi311530.
KEGGirno:311530.
UCSCiRGD:1306009. rat.

Similar proteinsi

Entry informationi

Entry nameiNANP_RAT
AccessioniPrimary (citable) accession number: Q5M969
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 1, 2005
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome