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Protein

BTB/POZ domain-containing protein KCTD1

Gene

Kctd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD1
Gene namesi
Name:Kctd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918269. Kctd1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471451 – 257BTB/POZ domain-containing protein KCTD1Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5M956.
PeptideAtlasiQ5M956.
PRIDEiQ5M956.

PTM databases

iPTMnetiQ5M956.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036225.
ExpressionAtlasiQ5M956. baseline and differential.
GenevisibleiQ5M956. MM.

Interactioni

Subunit structurei

Can form homodimers. Interacts with TFAP2A, TFAP2B and TFAP2C via the BTB domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128070.

Structurei

3D structure databases

ProteinModelPortaliQ5M956.
SMRiQ5M956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 100BTBAdd BLAST71

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000232179.
HOVERGENiHBG055358.
InParanoidiQ5M956.
KOiK21754.
PhylomeDBiQ5M956.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5M956-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPLITRSP ASPLNNQGIP TPAQLTKSNA PVHIDVGGHM YTSSLATLTK
60 70 80 90 100
YPESRIGRLF DGTEPIVLDS LKQHYFIDRD GQMFRYILNF LRTSKLLIPD
110 120 130 140 150
DFKDYTLLYE EAKYFQLQPM LLEMERWKQD RETGRFSRPC ECLVVRVAPD
160 170 180 190 200
LGERITLSGD KSLIEEVFPE IGDVMCNSVN AGWNHDSTHV IRFPLNGYCH
210 220 230 240 250
LNSVQVLERL QQRGFEIVGS CGGGVDSSQF SEYVLRRELR RTPRVPSVIR

IKQEPLD
Length:257
Mass (Da):29,405
Last modified:February 1, 2005 - v1
Checksum:i0513F3483A3C13A6
GO
Isoform 2 (identifier: Q5M956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFQDSRPNM

Show »
Length:265
Mass (Da):30,381
Checksum:i00DCD59E13813A5E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0199311M → MFQDSRPNM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY899808 mRNA. Translation: AAW88504.1.
BC087623 mRNA. Translation: AAH87623.1.
CCDSiCCDS50229.1. [Q5M956-2]
RefSeqiNP_598873.2. NM_134112.5. [Q5M956-2]
XP_006525548.1. XM_006525485.3. [Q5M956-1]
UniGeneiMm.329299.

Genome annotation databases

EnsembliENSMUST00000025992; ENSMUSP00000025992; ENSMUSG00000036225. [Q5M956-2]
GeneIDi106931.
KEGGimmu:106931.
UCSCiuc008edo.1. mouse. [Q5M956-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKCTD1_MOUSE
AccessioniPrimary (citable) accession number: Q5M956
Secondary accession number(s): Q5EER9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 1, 2005
Last modified: September 27, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot