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Q5M939 (HAT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase type B catalytic subunit

EC=2.3.1.48
Alternative name(s):
Histone acetyltransferase 1
Gene names
Name:Hat1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes By similarity.

Subcellular location

Nucleus matrix By similarity.

Sequence similarities

Belongs to the HAT1 family.

Ontologies

Keywords
   Cellular componentNucleus
   Molecular functionAcyltransferase
Transferase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchromatin silencing at telomere

Inferred from electronic annotation. Source: InterPro

response to nutrient

Inferred from expression pattern PubMed 17182829. Source: RGD

   Cellular_componentnuclear matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 419418Histone acetyltransferase type B catalytic subunit
PRO_0000227730

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue91N6-acetyllysine By similarity
Modified residue151N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M939 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: AF111B82A7370238

FASTA41949,241
        10         20         30         40         50         60 
MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT FFPEYTHQLF 

        70         80         90        100        110        120 
GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD CVEADDVEGK IRQIIPPGFC 

       130        140        150        160        170        180 
TNTNDFLSLL EKEADFKPFG TLLHTYSVPS PTGGENFTFQ IYKADMTCRG FREYHERLQT 

       190        200        210        220        230        240 
FLMWFIETAS FIDVDDERWH YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ 

       250        260        270        280        290        300 
MLILTPFQGQ GHGAQLLETV HRYYIASSSV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF 

       310        320        330        340        350        360 
SRERLLQGFN EDMAIQAQQK FKINKQHARR VYEILRLLVT DMSDAEQCRS YRLDIKRRLI 

       370        380        390        400        410 
SPYKKKQTDL AKMRKCLRPE ELTNQMNQIE ISVQHEQLEE QFQELVEDYR RVIERLAQE 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC087663 mRNA. Translation: AAH87663.1.
RefSeqNP_001009657.1. NM_001009657.1.
UniGeneRn.139751.

3D structure databases

ProteinModelPortalQ5M939.
SMRQ5M939. Positions 23-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000060926.

PTM databases

PhosphoSiteQ5M939.

Proteomic databases

PRIDEQ5M939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000002085; ENSRNOP00000002085; ENSRNOG00000001524.
GeneID296501.
KEGGrno:296501.
UCSCRGD:1305716. rat.

Organism-specific databases

CTD8520.
RGD1305716. Hat1.

Phylogenomic databases

eggNOGNOG326277.
GeneTreeENSGT00390000007069.
HOGENOMHOG000231943.
HOVERGENHBG005945.
InParanoidQ5M939.
KOK11303.
OMAHRYYIAS.
OrthoDBEOG7Z3F4M.

Gene expression databases

GenevestigatorQ5M939.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERPTHR12046. PTHR12046. 1 hit.
PfamPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Other

NextBio641298.
PROQ5M939.

Entry information

Entry nameHAT1_RAT
AccessionPrimary (citable) accession number: Q5M939
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families