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Q5M939

- HAT1_RAT

UniProt

Q5M939 - HAT1_RAT

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Protein

Histone acetyltransferase type B catalytic subunit

Gene

Hat1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei199 – 1991Interaction with histone H4 N-terminusBy similarity
Active sitei276 – 2761Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA replication-dependent nucleosome assembly Source: Ensembl
  3. DNA replication-independent nucleosome assembly Source: Ensembl
  4. histone H4 acetylation Source: UniProtKB
  5. response to nutrient Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_198384. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase 1
Gene namesi
Name:Hat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1305716. Hat1.

Subcellular locationi

Nucleus matrix By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 419418Histone acetyltransferase type B catalytic subunitPRO_0000227730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei9 – 91N6-acetyllysineBy similarity
Modified residuei15 – 151N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ5M939.

PTM databases

PhosphoSiteiQ5M939.

Expressioni

Gene expression databases

GenevestigatoriQ5M939.

Interactioni

Subunit structurei

Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060926.

Structurei

3D structure databases

ProteinModelPortaliQ5M939.
SMRiQ5M939. Positions 23-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Interaction with histone H4 N-terminusBy similarity
Regioni225 – 2273Interaction with histone H4 N-terminusBy similarity
Regioni241 – 2433Acetyl-CoA bindingBy similarity
Regioni248 – 2547Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiNOG326277.
GeneTreeiENSGT00390000007069.
HOGENOMiHOG000231943.
HOVERGENiHBG005945.
InParanoidiQ5M939.
KOiK11303.
OMAiHRYYIAS.
OrthoDBiEOG7Z3F4M.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M939-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT
60 70 80 90 100
FFPEYTHQLF GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD
110 120 130 140 150
CVEADDVEGK IRQIIPPGFC TNTNDFLSLL EKEADFKPFG TLLHTYSVPS
160 170 180 190 200
PTGGENFTFQ IYKADMTCRG FREYHERLQT FLMWFIETAS FIDVDDERWH
210 220 230 240 250
YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ MLILTPFQGQ
260 270 280 290 300
GHGAQLLETV HRYYIASSSV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF
310 320 330 340 350
SRERLLQGFN EDMAIQAQQK FKINKQHARR VYEILRLLVT DMSDAEQCRS
360 370 380 390 400
YRLDIKRRLI SPYKKKQTDL AKMRKCLRPE ELTNQMNQIE ISVQHEQLEE
410
QFQELVEDYR RVIERLAQE
Length:419
Mass (Da):49,241
Last modified:February 1, 2005 - v1
Checksum:iAF111B82A7370238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087663 mRNA. Translation: AAH87663.1.
RefSeqiNP_001009657.1. NM_001009657.1.
UniGeneiRn.139751.

Genome annotation databases

EnsembliENSRNOT00000002085; ENSRNOP00000002085; ENSRNOG00000001524.
GeneIDi296501.
KEGGirno:296501.
UCSCiRGD:1305716. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087663 mRNA. Translation: AAH87663.1 .
RefSeqi NP_001009657.1. NM_001009657.1.
UniGenei Rn.139751.

3D structure databases

ProteinModelPortali Q5M939.
SMRi Q5M939. Positions 23-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000060926.

PTM databases

PhosphoSitei Q5M939.

Proteomic databases

PRIDEi Q5M939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002085 ; ENSRNOP00000002085 ; ENSRNOG00000001524 .
GeneIDi 296501.
KEGGi rno:296501.
UCSCi RGD:1305716. rat.

Organism-specific databases

CTDi 8520.
RGDi 1305716. Hat1.

Phylogenomic databases

eggNOGi NOG326277.
GeneTreei ENSGT00390000007069.
HOGENOMi HOG000231943.
HOVERGENi HBG005945.
InParanoidi Q5M939.
KOi K11303.
OMAi HRYYIAS.
OrthoDBi EOG7Z3F4M.

Enzyme and pathway databases

Reactomei REACT_198384. HATs acetylate histones.

Miscellaneous databases

NextBioi 641298.
PROi Q5M939.

Gene expression databases

Genevestigatori Q5M939.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHAT1_RAT
AccessioniPrimary (citable) accession number: Q5M939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3