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Protein

Histone acetyltransferase type B catalytic subunit

Gene

Hat1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei276Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase 1
Gene namesi
Name:Hat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1305716 Hat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002277302 – 419Histone acetyltransferase type B catalytic subunitAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5M939
PRIDEiQ5M939

PTM databases

iPTMnetiQ5M939
PhosphoSitePlusiQ5M939

Expressioni

Gene expression databases

BgeeiENSRNOG00000001524
GenevisibleiQ5M939 RN

Interactioni

Subunit structurei

Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei199Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002085

Structurei

3D structure databases

ProteinModelPortaliQ5M939
SMRiQ5M939
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 64Interaction with histone H4 N-terminusBy similarity3
Regioni225 – 227Interaction with histone H4 N-terminusBy similarity3
Regioni241 – 243Acetyl-CoA bindingBy similarity3
Regioni248 – 254Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiKOG2696 Eukaryota
ENOG410XPH4 LUCA
GeneTreeiENSGT00390000007069
HOGENOMiHOG000231943
HOVERGENiHBG005945
InParanoidiQ5M939
KOiK11303
OMAiMAHQIFG
OrthoDBiEOG091G0A79

Family and domain databases

Gene3Di1.10.10.390, 1 hit
3.90.360.10, 2 hits
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR019467 Hat1_N
IPR037113 Hat1_N_sf
IPR017380 Hist_AcTrfase_B-typ_cat-su
IPR013523 Hist_AcTrfase_HAT1_C
PANTHERiPTHR12046 PTHR12046, 1 hit
PfamiView protein in Pfam
PF10394 Hat1_N, 1 hit
PIRSFiPIRSF038084 HAT-B_cat, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT
60 70 80 90 100
FFPEYTHQLF GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD
110 120 130 140 150
CVEADDVEGK IRQIIPPGFC TNTNDFLSLL EKEADFKPFG TLLHTYSVPS
160 170 180 190 200
PTGGENFTFQ IYKADMTCRG FREYHERLQT FLMWFIETAS FIDVDDERWH
210 220 230 240 250
YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ MLILTPFQGQ
260 270 280 290 300
GHGAQLLETV HRYYIASSSV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF
310 320 330 340 350
SRERLLQGFN EDMAIQAQQK FKINKQHARR VYEILRLLVT DMSDAEQCRS
360 370 380 390 400
YRLDIKRRLI SPYKKKQTDL AKMRKCLRPE ELTNQMNQIE ISVQHEQLEE
410
QFQELVEDYR RVIERLAQE
Length:419
Mass (Da):49,241
Last modified:February 1, 2005 - v1
Checksum:iAF111B82A7370238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087663 mRNA Translation: AAH87663.1
RefSeqiNP_001009657.1, NM_001009657.1
UniGeneiRn.139751

Genome annotation databases

EnsembliENSRNOT00000002085; ENSRNOP00000002085; ENSRNOG00000001524
GeneIDi296501
KEGGirno:296501
UCSCiRGD:1305716 rat

Similar proteinsi

Entry informationi

Entry nameiHAT1_RAT
AccessioniPrimary (citable) accession number: Q5M939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 1, 2005
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health