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Q5M939

- HAT1_RAT

UniProt

Q5M939 - HAT1_RAT

Protein

Histone acetyltransferase type B catalytic subunit

Gene

Hat1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chromatin silencing at telomere Source: InterPro
    2. response to nutrient Source: RGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_198384. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
    Alternative name(s):
    Histone acetyltransferase 1
    Gene namesi
    Name:Hat1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1305716. Hat1.

    Subcellular locationi

    Nucleus matrix By similarity

    GO - Cellular componenti

    1. nuclear matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 419418Histone acetyltransferase type B catalytic subunitPRO_0000227730Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei9 – 91N6-acetyllysineBy similarity
    Modified residuei15 – 151N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ5M939.

    PTM databases

    PhosphoSiteiQ5M939.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5M939.

    Interactioni

    Subunit structurei

    Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000060926.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M939.
    SMRiQ5M939. Positions 23-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAT1 family.Curated

    Phylogenomic databases

    eggNOGiNOG326277.
    GeneTreeiENSGT00390000007069.
    HOGENOMiHOG000231943.
    HOVERGENiHBG005945.
    InParanoidiQ5M939.
    KOiK11303.
    OMAiHRYYIAS.
    OrthoDBiEOG7Z3F4M.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    [Graphical view]
    PANTHERiPTHR12046. PTHR12046. 1 hit.
    PfamiPF10394. Hat1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5M939-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT    50
    FFPEYTHQLF GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD 100
    CVEADDVEGK IRQIIPPGFC TNTNDFLSLL EKEADFKPFG TLLHTYSVPS 150
    PTGGENFTFQ IYKADMTCRG FREYHERLQT FLMWFIETAS FIDVDDERWH 200
    YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ MLILTPFQGQ 250
    GHGAQLLETV HRYYIASSSV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF 300
    SRERLLQGFN EDMAIQAQQK FKINKQHARR VYEILRLLVT DMSDAEQCRS 350
    YRLDIKRRLI SPYKKKQTDL AKMRKCLRPE ELTNQMNQIE ISVQHEQLEE 400
    QFQELVEDYR RVIERLAQE 419
    Length:419
    Mass (Da):49,241
    Last modified:February 1, 2005 - v1
    Checksum:iAF111B82A7370238
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087663 mRNA. Translation: AAH87663.1.
    RefSeqiNP_001009657.1. NM_001009657.1.
    UniGeneiRn.139751.

    Genome annotation databases

    EnsembliENSRNOT00000002085; ENSRNOP00000002085; ENSRNOG00000001524.
    GeneIDi296501.
    KEGGirno:296501.
    UCSCiRGD:1305716. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087663 mRNA. Translation: AAH87663.1 .
    RefSeqi NP_001009657.1. NM_001009657.1.
    UniGenei Rn.139751.

    3D structure databases

    ProteinModelPortali Q5M939.
    SMRi Q5M939. Positions 23-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000060926.

    PTM databases

    PhosphoSitei Q5M939.

    Proteomic databases

    PRIDEi Q5M939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002085 ; ENSRNOP00000002085 ; ENSRNOG00000001524 .
    GeneIDi 296501.
    KEGGi rno:296501.
    UCSCi RGD:1305716. rat.

    Organism-specific databases

    CTDi 8520.
    RGDi 1305716. Hat1.

    Phylogenomic databases

    eggNOGi NOG326277.
    GeneTreei ENSGT00390000007069.
    HOGENOMi HOG000231943.
    HOVERGENi HBG005945.
    InParanoidi Q5M939.
    KOi K11303.
    OMAi HRYYIAS.
    OrthoDBi EOG7Z3F4M.

    Enzyme and pathway databases

    Reactomei REACT_198384. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 641298.
    PROi Q5M939.

    Gene expression databases

    Genevestigatori Q5M939.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    [Graphical view ]
    PANTHERi PTHR12046. PTHR12046. 1 hit.
    Pfami PF10394. Hat1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiHAT1_RAT
    AccessioniPrimary (citable) accession number: Q5M939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3