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Protein

Probable tRNA pseudouridine synthase 1

Gene

Trub1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.By similarity

Catalytic activityi

tRNA uridine = tRNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase 1 (EC:5.4.99.-)
Gene namesi
Name:Trub1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308502. Trub1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 341340Probable tRNA pseudouridine synthase 1PRO_0000252089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5M934.
PRIDEiQ5M934.

Expressioni

Gene expression databases

GenevisibleiQ5M934. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023309.

Structurei

3D structure databases

ProteinModelPortaliQ5M934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
GeneTreeiENSGT00530000063611.
HOGENOMiHOG000063679.
HOVERGENiHBG094094.
InParanoidiQ5M934.
KOiK03177.
OMAiKFQPPFF.
OrthoDBiEOG7RFTHX.
PhylomeDBiQ5M934.
TreeFamiTF320759.

Family and domain databases

HAMAPiMF_01080. TruB_bact.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR014780. tRNA_psdUridine_synth_TruB.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEEAEVVS PLIVDTAPDT SGTAAASLAA AVSAAAAAAR TGSQAQVSKA
60 70 80 90 100
ALAAKLMSLS GVFAVHKPKG PTSAELLNRL KEKLLAEAGL PSPEWNKRQK
110 120 130 140 150
QTLKVGHGGT LDSAAQGVLV VGIGRGTKML TSMLSGSKRY IATGELGKAT
160 170 180 190 200
DTLDSTGKVT EEKPYDKITQ EDIEGILQKF TGNIMQVPPL YSALKKDGQR
210 220 230 240 250
LSTLMKRGET VEARPARPVT VHSISLLKYQ PPFFTLDVEC GGGFYIRSLV
260 270 280 290 300
SDIGKELSSC ATVLELTRTK QGPFTLAQHA LPEDRWTIND IAQSLKRCTS
310 320 330 340
LLPEELTFKK SKSEPSSDQA LSCGYITLRE TKREDDTVKT L
Length:341
Mass (Da):36,404
Last modified:February 1, 2005 - v1
Checksum:i1DB4BC933B8692A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087683 mRNA. Translation: AAH87683.1.
RefSeqiNP_001012173.1. NM_001012173.1.
UniGeneiRn.24324.

Genome annotation databases

EnsembliENSRNOT00000023309; ENSRNOP00000023309; ENSRNOG00000017321.
GeneIDi361775.
KEGGirno:361775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087683 mRNA. Translation: AAH87683.1.
RefSeqiNP_001012173.1. NM_001012173.1.
UniGeneiRn.24324.

3D structure databases

ProteinModelPortaliQ5M934.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023309.

Proteomic databases

PaxDbiQ5M934.
PRIDEiQ5M934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023309; ENSRNOP00000023309; ENSRNOG00000017321.
GeneIDi361775.
KEGGirno:361775.

Organism-specific databases

CTDi142940.
RGDi1308502. Trub1.

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
GeneTreeiENSGT00530000063611.
HOGENOMiHOG000063679.
HOVERGENiHBG094094.
InParanoidiQ5M934.
KOiK03177.
OMAiKFQPPFF.
OrthoDBiEOG7RFTHX.
PhylomeDBiQ5M934.
TreeFamiTF320759.

Miscellaneous databases

NextBioi677570.
PROiQ5M934.

Gene expression databases

GenevisibleiQ5M934. RN.

Family and domain databases

HAMAPiMF_01080. TruB_bact.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR014780. tRNA_psdUridine_synth_TruB.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTRUB1_RAT
AccessioniPrimary (citable) accession number: Q5M934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 1, 2005
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.