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Protein

Probable tRNA pseudouridine synthase 1

Gene

Trub1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.By similarity

Catalytic activityi

tRNA uridine = tRNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei112NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase 1 (EC:5.4.99.-)
Gene namesi
Name:Trub1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308502 Trub1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002520892 – 341Probable tRNA pseudouridine synthase 1Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5M934
PRIDEiQ5M934

Expressioni

Gene expression databases

BgeeiENSRNOG00000017321
GenevisibleiQ5M934 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023309

Structurei

3D structure databases

ProteinModelPortaliQ5M934
SMRiQ5M934
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Phylogenomic databases

eggNOGiKOG2529 Eukaryota
COG0130 LUCA
GeneTreeiENSGT00530000063611
HOGENOMiHOG000063679
HOVERGENiHBG094094
InParanoidiQ5M934
KOiK03177
OMAiKFQPPFF
OrthoDBiEOG091G0FSQ
PhylomeDBiQ5M934
TreeFamiTF320759

Family and domain databases

HAMAPiMF_01080 TruB_bact, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR014780 tRNA_psdUridine_synth_TruB
PANTHERiPTHR13767 PTHR13767, 1 hit
PfamiView protein in Pfam
PF01509 TruB_N, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00431 TruB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEEAEVVS PLIVDTAPDT SGTAAASLAA AVSAAAAAAR TGSQAQVSKA
60 70 80 90 100
ALAAKLMSLS GVFAVHKPKG PTSAELLNRL KEKLLAEAGL PSPEWNKRQK
110 120 130 140 150
QTLKVGHGGT LDSAAQGVLV VGIGRGTKML TSMLSGSKRY IATGELGKAT
160 170 180 190 200
DTLDSTGKVT EEKPYDKITQ EDIEGILQKF TGNIMQVPPL YSALKKDGQR
210 220 230 240 250
LSTLMKRGET VEARPARPVT VHSISLLKYQ PPFFTLDVEC GGGFYIRSLV
260 270 280 290 300
SDIGKELSSC ATVLELTRTK QGPFTLAQHA LPEDRWTIND IAQSLKRCTS
310 320 330 340
LLPEELTFKK SKSEPSSDQA LSCGYITLRE TKREDDTVKT L
Length:341
Mass (Da):36,404
Last modified:February 1, 2005 - v1
Checksum:i1DB4BC933B8692A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087683 mRNA Translation: AAH87683.1
RefSeqiNP_001012173.1, NM_001012173.1
UniGeneiRn.24324

Genome annotation databases

EnsembliENSRNOT00000023309; ENSRNOP00000023309; ENSRNOG00000017321
GeneIDi361775
KEGGirno:361775

Similar proteinsi

Entry informationi

Entry nameiTRUB1_RAT
AccessioniPrimary (citable) accession number: Q5M934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 1, 2005
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health