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Protein

E3 ubiquitin-protein ligase RNF135

Gene

Rnf135

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 6747RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Immunity, Innate immunity, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF135 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 135
Gene namesi
Name:Rnf135
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305252. Rnf135.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415E3 ubiquitin-protein ligase RNF135PRO_0000280559Add
BLAST

Proteomic databases

PaxDbiQ5M929.
PRIDEiQ5M929.

Interactioni

Subunit structurei

Interacts with DDX58. Interacts with PCBP2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005428.

Structurei

3D structure databases

ProteinModelPortaliQ5M929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 415188B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 20626Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 6747RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
HOVERGENiHBG056606.
InParanoidiQ5M929.
KOiK16272.
OMAiNCSHWAV.
OrthoDBiEOG79KPFR.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAACPGTAV PVWLSEEDLS CIICQGLLDW PTTLPCGHSF CLQCLKDLWV
60 70 80 90 100
SKRAGVDSCP WACPICRKGP SAKPVLHKNP LLQDLVDKYR QAALELEAGP
110 120 130 140 150
EPAPVPRSLC TPTPPQVTVQ KSTTQVVQEL TELVGQLVDI VKSLQTQRPS
160 170 180 190 200
LASGLDNALG ILHMDSSSEE EYPLDSPKLV TFSASQKKIQ EILRDLEKIQ
210 220 230 240 250
ETLQGSVTGN EAPKKQVEEM ASSVGLLPDQ RYPVSRKASQ FSLWAISPTF
260 270 280 290 300
DLRSLSCNLE VSNNCRMVTV SRALQPYHWS SERFSISQVL CSQAFSSGQK
310 320 330 340 350
YWEVDTRNCS HWAVGVASWG MKRDKMLGRT MDSWCIEWRG PSQFSAWAMM
360 370 380 390 400
KKTDLSSGPP EVVGVWLDLE LGKLAFYSVA DQERPLYECE VSSSSPLHPA
410
FWLYGLTPGN YLEIL
Length:415
Mass (Da):46,012
Last modified:February 1, 2005 - v1
Checksum:iEE4FE96A74586AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087718 mRNA. Translation: AAH87718.1.
RefSeqiNP_001012010.1. NM_001012010.1.
UniGeneiRn.225330.

Genome annotation databases

GeneIDi303350.
KEGGirno:303350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087718 mRNA. Translation: AAH87718.1.
RefSeqiNP_001012010.1. NM_001012010.1.
UniGeneiRn.225330.

3D structure databases

ProteinModelPortaliQ5M929.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005428.

Proteomic databases

PaxDbiQ5M929.
PRIDEiQ5M929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi303350.
KEGGirno:303350.

Organism-specific databases

CTDi84282.
RGDi1305252. Rnf135.

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
HOVERGENiHBG056606.
InParanoidiQ5M929.
KOiK16272.
OMAiNCSHWAV.
OrthoDBiEOG79KPFR.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ5M929.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRN135_RAT
AccessioniPrimary (citable) accession number: Q5M929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 1, 2005
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.