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Q5M8Z6 (ASSY_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:ass1
Synonyms:ass
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
Urea cycle
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

urea cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000321325

Regions

Nucleotide binding11 – 199ATP By similarity
Nucleotide binding116 – 1249ATP By similarity

Sites

Binding site371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site881Citrulline By similarity
Binding site931Citrulline By similarity
Binding site1201Aspartate By similarity
Binding site1241Aspartate By similarity
Binding site1241Citrulline By similarity
Binding site1251Aspartate By similarity
Binding site1281Citrulline By similarity
Binding site1811Citrulline By similarity
Binding site1901Citrulline By similarity
Binding site2711Citrulline By similarity
Binding site2831Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M8Z6 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: A4BB4A6010B59B5C

FASTA41246,851
        10         20         30         40         50         60 
MSQSKGMVVL AYSGGLDTSC ILVWLKEQGY DVIAYLANIG QNEDFEAARK KAVNLGAKKV 

        70         80         90        100        110        120 
YIEDMRQQFV EEYIWPAVQA NAIYEDRYLL GTSLARPCIA KKQVEIAKKE AAEYVSHGAT 

       130        140        150        160        170        180 
GKGNDQIRFE LTCYALYPEV KIIAPWRMPE FYNRFRGRSD LMEYAKKHNI PVPVTPKDPW 

       190        200        210        220        230        240 
SMDENIMHIS YEGGILENPK NHAPPGLYLK TKNPATSPNE PDILEIEFKK GVPVKVTNTK 

       250        260        270        280        290        300 
EKTQHSSALG LFCYLNEVAG KHGVGRIDIV ENRFIGMKSR GIYETPAGTI LYQAHLDVEA 

       310        320        330        340        350        360 
FTMDREVRKI KQHLSQRFAE QIYNGFWYSP ECEFVRSCIT KSQEMVEGKV LVSVLKGQVY 

       370        380        390        400        410 
VLGREAPHSL YNEELVSMDV QGDYDPADAC GFIRINALRL KEFHRLQKSK KN 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC087767 mRNA. Translation: AAH87767.1.
RefSeqNP_001011212.1. NM_001011212.1.
UniGeneStr.26669.

3D structure databases

ProteinModelPortalQ5M8Z6.
SMRQ5M8Z6. Positions 5-407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000002868.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID496645.
KEGGxtr:496645.

Organism-specific databases

CTD445.
XenbaseXB-GENE-977784. ass1.

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
HOVERGENHBG001717.
InParanoidQ5M8Z6.
KOK01940.

Enzyme and pathway databases

UniPathwayUPA00068; UER00113.
UPA00158; UER00272.

Gene expression databases

BgeeQ5M8Z6.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_XENTR
AccessionPrimary (citable) accession number: Q5M8Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways