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Q5M8Z6

- ASSY_XENTR

UniProt

Q5M8Z6 - ASSY_XENTR

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Protein

Argininosuccinate synthase

Gene
ass1, ass
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei88 – 881Citrulline By similarity
Binding sitei93 – 931Citrulline By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei124 – 1241Citrulline By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei128 – 1281Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei271 – 2711Citrulline By similarity
Binding sitei283 – 2831Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity
Nucleotide bindingi116 – 1249ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-UniPathway
  2. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
UPA00158; UER00272.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:ass1
Synonyms:ass
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-977784. ass1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Argininosuccinate synthaseUniRule annotationPRO_0000321325Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5M8Z6.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi8364.ENSXETP00000002868.

Structurei

3D structure databases

ProteinModelPortaliQ5M8Z6.
SMRiQ5M8Z6. Positions 5-407.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
HOVERGENiHBG001717.
InParanoidiQ5M8Z6.
KOiK01940.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M8Z6-1 [UniParc]FASTAAdd to Basket

« Hide

MSQSKGMVVL AYSGGLDTSC ILVWLKEQGY DVIAYLANIG QNEDFEAARK    50
KAVNLGAKKV YIEDMRQQFV EEYIWPAVQA NAIYEDRYLL GTSLARPCIA 100
KKQVEIAKKE AAEYVSHGAT GKGNDQIRFE LTCYALYPEV KIIAPWRMPE 150
FYNRFRGRSD LMEYAKKHNI PVPVTPKDPW SMDENIMHIS YEGGILENPK 200
NHAPPGLYLK TKNPATSPNE PDILEIEFKK GVPVKVTNTK EKTQHSSALG 250
LFCYLNEVAG KHGVGRIDIV ENRFIGMKSR GIYETPAGTI LYQAHLDVEA 300
FTMDREVRKI KQHLSQRFAE QIYNGFWYSP ECEFVRSCIT KSQEMVEGKV 350
LVSVLKGQVY VLGREAPHSL YNEELVSMDV QGDYDPADAC GFIRINALRL 400
KEFHRLQKSK KN 412
Length:412
Mass (Da):46,851
Last modified:February 1, 2005 - v1
Checksum:iA4BB4A6010B59B5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC087767 mRNA. Translation: AAH87767.1.
RefSeqiNP_001011212.1. NM_001011212.1.
UniGeneiStr.26669.

Genome annotation databases

GeneIDi496645.
KEGGixtr:496645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC087767 mRNA. Translation: AAH87767.1 .
RefSeqi NP_001011212.1. NM_001011212.1.
UniGenei Str.26669.

3D structure databases

ProteinModelPortali Q5M8Z6.
SMRi Q5M8Z6. Positions 5-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000002868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 496645.
KEGGi xtr:496645.

Organism-specific databases

CTDi 445.
Xenbasei XB-GENE-977784. ass1.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
HOVERGENi HBG001717.
InParanoidi Q5M8Z6.
KOi K01940.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
UPA00158 ; UER00272 .

Gene expression databases

Bgeei Q5M8Z6.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiASSY_XENTR
AccessioniPrimary (citable) accession number: Q5M8Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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