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Q5M8Z6

- ASSY_XENTR

UniProt

Q5M8Z6 - ASSY_XENTR

Protein

Argininosuccinate synthase

Gene

ass1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei88 – 881CitrullineBy similarity
    Binding sitei93 – 931CitrullineBy similarity
    Binding sitei120 – 1201AspartateBy similarity
    Binding sitei124 – 1241AspartateBy similarity
    Binding sitei124 – 1241CitrullineBy similarity
    Binding sitei125 – 1251AspartateBy similarity
    Binding sitei128 – 1281CitrullineBy similarity
    Binding sitei181 – 1811CitrullineBy similarity
    Binding sitei190 – 1901CitrullineBy similarity
    Binding sitei271 – 2711CitrullineBy similarity
    Binding sitei283 – 2831CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 199ATPBy similarity
    Nucleotide bindingi116 – 1249ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-UniPathway
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.
    UPA00158; UER00272.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:ass1
    Synonyms:ass
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-977784. ass1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Argininosuccinate synthasePRO_0000321325Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ5M8Z6.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000002868.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M8Z6.
    SMRiQ5M8Z6. Positions 5-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    HOVERGENiHBG001717.
    InParanoidiQ5M8Z6.
    KOiK01940.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5M8Z6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSKGMVVL AYSGGLDTSC ILVWLKEQGY DVIAYLANIG QNEDFEAARK    50
    KAVNLGAKKV YIEDMRQQFV EEYIWPAVQA NAIYEDRYLL GTSLARPCIA 100
    KKQVEIAKKE AAEYVSHGAT GKGNDQIRFE LTCYALYPEV KIIAPWRMPE 150
    FYNRFRGRSD LMEYAKKHNI PVPVTPKDPW SMDENIMHIS YEGGILENPK 200
    NHAPPGLYLK TKNPATSPNE PDILEIEFKK GVPVKVTNTK EKTQHSSALG 250
    LFCYLNEVAG KHGVGRIDIV ENRFIGMKSR GIYETPAGTI LYQAHLDVEA 300
    FTMDREVRKI KQHLSQRFAE QIYNGFWYSP ECEFVRSCIT KSQEMVEGKV 350
    LVSVLKGQVY VLGREAPHSL YNEELVSMDV QGDYDPADAC GFIRINALRL 400
    KEFHRLQKSK KN 412
    Length:412
    Mass (Da):46,851
    Last modified:February 1, 2005 - v1
    Checksum:iA4BB4A6010B59B5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087767 mRNA. Translation: AAH87767.1.
    RefSeqiNP_001011212.1. NM_001011212.1.
    UniGeneiStr.26669.

    Genome annotation databases

    GeneIDi496645.
    KEGGixtr:496645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087767 mRNA. Translation: AAH87767.1 .
    RefSeqi NP_001011212.1. NM_001011212.1.
    UniGenei Str.26669.

    3D structure databases

    ProteinModelPortali Q5M8Z6.
    SMRi Q5M8Z6. Positions 5-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000002868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 496645.
    KEGGi xtr:496645.

    Organism-specific databases

    CTDi 445.
    Xenbasei XB-GENE-977784. ass1.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    HOVERGENi HBG001717.
    InParanoidi Q5M8Z6.
    KOi K01940.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    UPA00158 ; UER00272 .

    Gene expression databases

    Bgeei Q5M8Z6.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiASSY_XENTR
    AccessioniPrimary (citable) accession number: Q5M8Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3