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Q5M8Z0 (BHMT1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Betaine--homocysteine S-methyltransferase 1

EC=2.1.1.5
Gene names
Name:bhmt
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline By similarity.

Catalytic activity

Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 Hcy-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Betaine--homocysteine S-methyltransferase 1
PRO_0000273223

Regions

Domain8 – 311304Hcy-binding

Sites

Metal binding2141Zinc By similarity
Metal binding2961Zinc By similarity
Metal binding2971Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M8Z0 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 079A8C12A4A73CDB

FASTA40344,154
        10         20         30         40         50         60 
MAPTGAKKGL LERLDAGEVV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP EAVRQLHREF 

        70         80         90        100        110        120 
LRAGANVMQT FTFYASDDKL ENRGNYVAKK ISGQKVNEAA CDIAREVANE GDALVAGGVS 

       130        140        150        160        170        180 
QTPSYLSCKS EVEVKGIFRK QLDVFIKKNV DFLIAEYFEH VEEAVWAVEV LKESGKPVAA 

       190        200        210        220        230        240 
TLCIGPQGDL NGVTPGECAV RLAKAGASVV GVNCHFDPMT CIATVKLMKE GLVAAKVKAH 

       250        260        270        280        290        300 
LMTQPLAYHT PDCGKQGFID LPEFPFALEP RIVTRWDIHK YAREAYNLGV RYIGGCCGFE 

       310        320        330        340        350        360 
PYHTRAIAEE LAPERGFLPP GSEKHGSWGS GLEMHTKPWV RARARRDYWE KLPPASGRPC 

       370        380        390        400 
CPSMSKPDAW GVTKGDADLM QQKEATTEQQ LIDLFAKQCI KSN 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC087774 mRNA. Translation: AAH87774.1.
BC089235 mRNA. Translation: AAH89235.1.
RefSeqNP_001011217.1. NM_001011217.1.
UniGeneStr.8632.

3D structure databases

ProteinModelPortalQ5M8Z0.
SMRQ5M8Z0. Positions 7-395.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000001133.

Proteomic databases

PaxDbQ5M8Z0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000001133; ENSXETP00000001133; ENSXETG00000000523.
GeneID496651.
KEGGxtr:496651.

Organism-specific databases

CTD635.
XenbaseXB-GENE-1008382. bhmt.

Phylogenomic databases

eggNOGCOG0646.
GeneTreeENSGT00390000003122.
HOGENOMHOG000231636.
HOVERGENHBG080367.
InParanoidQ5FWR7.
KOK00544.

Enzyme and pathway databases

UniPathwayUPA00051; UER00083.
UPA00291; UER00432.

Gene expression databases

BgeeQ5M8Z0.

Family and domain databases

Gene3D3.20.20.330. 1 hit.
InterProIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. S_MeTrfase.
[Graphical view]
PfamPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMSSF82282. SSF82282. 1 hit.
PROSITEPS50970. HCY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBHMT1_XENTR
AccessionPrimary (citable) accession number: Q5M8Z0
Secondary accession number(s): Q5FWR7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: February 1, 2005
Last modified: November 13, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways