Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Betaine--homocysteine S-methyltransferase 1

Gene

bhmt

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).By similarity

Catalytic activityi

Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: betaine degradation

This protein is involved in step 1 of the subpathway that synthesizes sarcosine from betaine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Betaine--homocysteine S-methyltransferase 1 (bhmt)
  2. no protein annotated in this organism
This subpathway is part of the pathway betaine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sarcosine from betaine, the pathway betaine degradation and in Amine and polyamine degradation.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route).
Proteins known to be involved in this subpathway in this organism are:
  1. Betaine--homocysteine S-methyltransferase 1 (bhmt), Betaine--homocysteine S-methyltransferase 1 (bhmt), Uncharacterized protein (MGC75760), Uncharacterized protein (mgc75760), Uncharacterized protein (MGC75760)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi214ZincPROSITE-ProRule annotation1
Metal bindingi296ZincPROSITE-ProRule annotation1
Metal bindingi297ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-XTR-1614635 Sulfur amino acid metabolism
R-XTR-6798163 Choline catabolism
UniPathwayiUPA00051; UER00083
UPA00291; UER00432

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine--homocysteine S-methyltransferase 1 (EC:2.1.1.5)
Gene namesi
Name:bhmt
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1008382 bhmt

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002732231 – 403Betaine--homocysteine S-methyltransferase 1Add BLAST403

Proteomic databases

PaxDbiQ5M8Z0
PRIDEiQ5M8Z0

Expressioni

Gene expression databases

BgeeiENSXETG00000000523
ExpressionAtlasiQ5M8Z0 baseline

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000059123

Structurei

3D structure databases

ProteinModelPortaliQ5M8Z0
SMRiQ5M8Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 311Hcy-bindingPROSITE-ProRule annotationAdd BLAST304

Phylogenomic databases

eggNOGiKOG1579 Eukaryota
COG0646 LUCA
GeneTreeiENSGT00390000003122
HOGENOMiHOG000231636
HOVERGENiHBG080367
InParanoidiQ5M8Z0
KOiK00544

Family and domain databases

Gene3Di3.20.20.330, 1 hit
InterProiView protein in InterPro
IPR017226 Betaine-hCys_S-MeTrfase_BHMT
IPR003726 HCY_dom
IPR036589 HCY_dom_sf
PfamiView protein in Pfam
PF02574 S-methyl_trans, 1 hit
PIRSFiPIRSF037505 Betaine_HMT, 1 hit
SUPFAMiSSF82282 SSF82282, 1 hit
PROSITEiView protein in PROSITE
PS50970 HCY, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M8Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTGAKKGL LERLDAGEVV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP
60 70 80 90 100
EAVRQLHREF LRAGANVMQT FTFYASDDKL ENRGNYVAKK ISGQKVNEAA
110 120 130 140 150
CDIAREVANE GDALVAGGVS QTPSYLSCKS EVEVKGIFRK QLDVFIKKNV
160 170 180 190 200
DFLIAEYFEH VEEAVWAVEV LKESGKPVAA TLCIGPQGDL NGVTPGECAV
210 220 230 240 250
RLAKAGASVV GVNCHFDPMT CIATVKLMKE GLVAAKVKAH LMTQPLAYHT
260 270 280 290 300
PDCGKQGFID LPEFPFALEP RIVTRWDIHK YAREAYNLGV RYIGGCCGFE
310 320 330 340 350
PYHTRAIAEE LAPERGFLPP GSEKHGSWGS GLEMHTKPWV RARARRDYWE
360 370 380 390 400
KLPPASGRPC CPSMSKPDAW GVTKGDADLM QQKEATTEQQ LIDLFAKQCI

KSN
Length:403
Mass (Da):44,154
Last modified:February 1, 2005 - v1
Checksum:i079A8C12A4A73CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087774 mRNA Translation: AAH87774.1
BC089235 mRNA Translation: AAH89235.1
RefSeqiNP_001011217.1, NM_001011217.1
UniGeneiStr.8632

Genome annotation databases

EnsembliENSXETT00000001133; ENSXETP00000001133; ENSXETG00000000523
GeneIDi496651
KEGGixtr:496651

Similar proteinsi

Entry informationi

Entry nameiBHMT1_XENTR
AccessioniPrimary (citable) accession number: Q5M8Z0
Secondary accession number(s): Q5FWR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health