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Q5M8Z0

- BHMT1_XENTR

UniProt

Q5M8Z0 - BHMT1_XENTR

Protein

Betaine--homocysteine S-methyltransferase 1

Gene

bhmt

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline By similarity.By similarity

    Catalytic activityi

    Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi214 – 2141ZincPROSITE-ProRule annotation
    Metal bindingi296 – 2961ZincPROSITE-ProRule annotation
    Metal bindingi297 – 2971ZincPROSITE-ProRule annotation

    GO - Molecular functioni

    1. betaine-homocysteine S-methyltransferase activity Source: UniProtKB-EC
    2. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. amino-acid betaine catabolic process Source: UniProtKB-UniPathway
    2. methionine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_225592. Sulfur amino acid metabolism.
    UniPathwayiUPA00051; UER00083.
    UPA00291; UER00432.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Betaine--homocysteine S-methyltransferase 1 (EC:2.1.1.5)
    Gene namesi
    Name:bhmt
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1008382. bhmt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Betaine--homocysteine S-methyltransferase 1PRO_0000273223Add
    BLAST

    Proteomic databases

    PaxDbiQ5M8Z0.

    Expressioni

    Gene expression databases

    BgeeiQ5M8Z0.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000001133.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M8Z0.
    SMRiQ5M8Z0. Positions 7-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 311304Hcy-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Hcy-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0646.
    GeneTreeiENSGT00390000003122.
    HOGENOMiHOG000231636.
    HOVERGENiHBG080367.
    InParanoidiQ5FWR7.
    KOiK00544.

    Family and domain databases

    Gene3Di3.20.20.330. 1 hit.
    InterProiIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
    IPR003726. S_MeTrfase.
    [Graphical view]
    PfamiPF02574. S-methyl_trans. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037505. Betaine_HMT. 1 hit.
    SUPFAMiSSF82282. SSF82282. 1 hit.
    PROSITEiPS50970. HCY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5M8Z0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPTGAKKGL LERLDAGEVV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP    50
    EAVRQLHREF LRAGANVMQT FTFYASDDKL ENRGNYVAKK ISGQKVNEAA 100
    CDIAREVANE GDALVAGGVS QTPSYLSCKS EVEVKGIFRK QLDVFIKKNV 150
    DFLIAEYFEH VEEAVWAVEV LKESGKPVAA TLCIGPQGDL NGVTPGECAV 200
    RLAKAGASVV GVNCHFDPMT CIATVKLMKE GLVAAKVKAH LMTQPLAYHT 250
    PDCGKQGFID LPEFPFALEP RIVTRWDIHK YAREAYNLGV RYIGGCCGFE 300
    PYHTRAIAEE LAPERGFLPP GSEKHGSWGS GLEMHTKPWV RARARRDYWE 350
    KLPPASGRPC CPSMSKPDAW GVTKGDADLM QQKEATTEQQ LIDLFAKQCI 400
    KSN 403
    Length:403
    Mass (Da):44,154
    Last modified:February 1, 2005 - v1
    Checksum:i079A8C12A4A73CDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087774 mRNA. Translation: AAH87774.1.
    BC089235 mRNA. Translation: AAH89235.1.
    RefSeqiNP_001011217.1. NM_001011217.1.
    UniGeneiStr.8632.

    Genome annotation databases

    EnsembliENSXETT00000001133; ENSXETP00000001133; ENSXETG00000000523.
    GeneIDi496651.
    KEGGixtr:496651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087774 mRNA. Translation: AAH87774.1 .
    BC089235 mRNA. Translation: AAH89235.1 .
    RefSeqi NP_001011217.1. NM_001011217.1.
    UniGenei Str.8632.

    3D structure databases

    ProteinModelPortali Q5M8Z0.
    SMRi Q5M8Z0. Positions 7-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000001133.

    Proteomic databases

    PaxDbi Q5M8Z0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000001133 ; ENSXETP00000001133 ; ENSXETG00000000523 .
    GeneIDi 496651.
    KEGGi xtr:496651.

    Organism-specific databases

    CTDi 635.
    Xenbasei XB-GENE-1008382. bhmt.

    Phylogenomic databases

    eggNOGi COG0646.
    GeneTreei ENSGT00390000003122.
    HOGENOMi HOG000231636.
    HOVERGENi HBG080367.
    InParanoidi Q5FWR7.
    KOi K00544.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00083 .
    UPA00291 ; UER00432 .
    Reactomei REACT_225592. Sulfur amino acid metabolism.

    Gene expression databases

    Bgeei Q5M8Z0.

    Family and domain databases

    Gene3Di 3.20.20.330. 1 hit.
    InterProi IPR017226. Betaine-hCys_S-MeTrfase_BHMT.
    IPR003726. S_MeTrfase.
    [Graphical view ]
    Pfami PF02574. S-methyl_trans. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037505. Betaine_HMT. 1 hit.
    SUPFAMi SSF82282. SSF82282. 1 hit.
    PROSITEi PS50970. HCY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiBHMT1_XENTR
    AccessioniPrimary (citable) accession number: Q5M8Z0
    Secondary accession number(s): Q5FWR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3