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Protein

Betaine--homocysteine S-methyltransferase 1

Gene

bhmt

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).By similarity

Catalytic activityi

Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi214 – 2141ZincPROSITE-ProRule annotation
Metal bindingi296 – 2961ZincPROSITE-ProRule annotation
Metal bindingi297 – 2971ZincPROSITE-ProRule annotation

GO - Molecular functioni

  1. betaine-homocysteine S-methyltransferase activity Source: UniProtKB-EC
  2. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. amino-acid betaine catabolic process Source: UniProtKB-UniPathway
  2. methionine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_225592. Sulfur amino acid metabolism.
UniPathwayiUPA00051; UER00083.
UPA00291; UER00432.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine--homocysteine S-methyltransferase 1 (EC:2.1.1.5)
Gene namesi
Name:bhmt
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1008382. bhmt.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Betaine--homocysteine S-methyltransferase 1PRO_0000273223Add
BLAST

Proteomic databases

PaxDbiQ5M8Z0.

Expressioni

Gene expression databases

BgeeiQ5M8Z0.
ExpressionAtlasiQ5M8Z0. baseline.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000001133.

Structurei

3D structure databases

ProteinModelPortaliQ5M8Z0.
SMRiQ5M8Z0. Positions 7-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 311304Hcy-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Hcy-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0646.
GeneTreeiENSGT00390000003122.
HOGENOMiHOG000231636.
HOVERGENiHBG080367.
InParanoidiQ5M8Z0.
KOiK00544.

Family and domain databases

Gene3Di3.20.20.330. 1 hit.
InterProiIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. S_MeTrfase.
[Graphical view]
PfamiPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMiSSF82282. SSF82282. 1 hit.
PROSITEiPS50970. HCY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M8Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTGAKKGL LERLDAGEVV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP
60 70 80 90 100
EAVRQLHREF LRAGANVMQT FTFYASDDKL ENRGNYVAKK ISGQKVNEAA
110 120 130 140 150
CDIAREVANE GDALVAGGVS QTPSYLSCKS EVEVKGIFRK QLDVFIKKNV
160 170 180 190 200
DFLIAEYFEH VEEAVWAVEV LKESGKPVAA TLCIGPQGDL NGVTPGECAV
210 220 230 240 250
RLAKAGASVV GVNCHFDPMT CIATVKLMKE GLVAAKVKAH LMTQPLAYHT
260 270 280 290 300
PDCGKQGFID LPEFPFALEP RIVTRWDIHK YAREAYNLGV RYIGGCCGFE
310 320 330 340 350
PYHTRAIAEE LAPERGFLPP GSEKHGSWGS GLEMHTKPWV RARARRDYWE
360 370 380 390 400
KLPPASGRPC CPSMSKPDAW GVTKGDADLM QQKEATTEQQ LIDLFAKQCI

KSN
Length:403
Mass (Da):44,154
Last modified:February 1, 2005 - v1
Checksum:i079A8C12A4A73CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087774 mRNA. Translation: AAH87774.1.
BC089235 mRNA. Translation: AAH89235.1.
RefSeqiNP_001011217.1. NM_001011217.1.
UniGeneiStr.8632.

Genome annotation databases

EnsembliENSXETT00000001133; ENSXETP00000001133; ENSXETG00000000523.
GeneIDi496651.
KEGGixtr:496651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087774 mRNA. Translation: AAH87774.1.
BC089235 mRNA. Translation: AAH89235.1.
RefSeqiNP_001011217.1. NM_001011217.1.
UniGeneiStr.8632.

3D structure databases

ProteinModelPortaliQ5M8Z0.
SMRiQ5M8Z0. Positions 7-395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000001133.

Proteomic databases

PaxDbiQ5M8Z0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000001133; ENSXETP00000001133; ENSXETG00000000523.
GeneIDi496651.
KEGGixtr:496651.

Organism-specific databases

CTDi635.
XenbaseiXB-GENE-1008382. bhmt.

Phylogenomic databases

eggNOGiCOG0646.
GeneTreeiENSGT00390000003122.
HOGENOMiHOG000231636.
HOVERGENiHBG080367.
InParanoidiQ5M8Z0.
KOiK00544.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00083.
UPA00291; UER00432.
ReactomeiREACT_225592. Sulfur amino acid metabolism.

Gene expression databases

BgeeiQ5M8Z0.
ExpressionAtlasiQ5M8Z0. baseline.

Family and domain databases

Gene3Di3.20.20.330. 1 hit.
InterProiIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. S_MeTrfase.
[Graphical view]
PfamiPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMiSSF82282. SSF82282. 1 hit.
PROSITEiPS50970. HCY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiBHMT1_XENTR
AccessioniPrimary (citable) accession number: Q5M8Z0
Secondary accession number(s): Q5FWR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: February 1, 2005
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.