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Q5M8W9 (HOGA1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

EC=4.1.3.16
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name=DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name=Probable KHG-aldolase
Gene names
Name:hoga1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the final step in the metabolic pathway of hydroxyproline By similarity.

Catalytic activity

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulation

Inhibited by divalent cations By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the DapA family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function4-hydroxy-2-oxoglutarate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2626Mitochondrion Potential
Chain27 – 3283024-hydroxy-2-oxoglutarate aldolase, mitochondrial
PRO_0000273350

Regions

Region76 – 772Substrate binding By similarity

Sites

Active site1951Schiff-base intermediate with substrate By similarity
Binding site1971Substrate By similarity
Binding site2211Substrate; via carbonyl oxygen By similarity
Site1671Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5M8W9 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 02B53CFDBC0D3326

FASTA32835,644
        10         20         30         40         50         60 
MFGRTLFPAR VIALGSGLFR TPLRTLAAGP ALSIGGIYPP IATPFTDKEE VDYGKLHENL 

        70         80         90        100        110        120 
QNYSSFPFRG FVVQGSNGEY AYLTREERLE VVRRVRQAVP KEKLIMAGSG CESTQATIEM 

       130        140        150        160        170        180 
TVEMAQSGAD AVLVVTPSYY RGKMTSSALV HHYTKVADHS PVPVVLYSVP ANTGLDLPVD 

       190        200        210        220        230        240 
AVVTLSQHPN IIGLKDSGGD ITRIGLIIHK TKHLGFQVLS GSAGFLLAGY SVGAVGGVCA 

       250        260        270        280        290        300 
LANVLGAQVC ELERLCLNGR WQEAKELQYR LIEPNTAVTR KFGIPGLKQA MEWFGFNGGK 

       310        320 
CRSPLLPLTE QEIKELRHIF TVNGWLSL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CF375968 mRNA. No translation available.
BC087798 mRNA. Translation: AAH87798.1.
RefSeqNP_001263607.1. NM_001276678.1.
UniGeneStr.8565.

3D structure databases

ProteinModelPortalQ5M8W9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000007453.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID496669.
KEGGxtr:496669.

Organism-specific databases

CTD112817.
XenbaseXB-GENE-957775. hoga1.

Phylogenomic databases

eggNOGCOG0329.
HOVERGENHBG081405.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Dihydrodipicolinate_synth_AS.
[Graphical view]
PANTHERPTHR12128. PTHR12128. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
PROSITEPS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOGA1_XENTR
AccessionPrimary (citable) accession number: Q5M8W9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families