Q5M8W9 (HOGA1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
EC=4.1.3.16

Alternative name(s):
Dihydrodipicolinate synthase-like
Short name=DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name=Probable KHG-aldolase

Gene names

Name:

hoga1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the final step in the metabolic pathway of hydroxyproline By similarity.
Catalytic activity	4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
Enzyme regulation	Inhibited by divalent cations By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the DapA family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	4-hydroxy-2-oxoglutarate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 26	26	Mitochondrion Potential
	Chain	27 – 328	302	Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial		PRO_0000273350
Regions
	Region	76 – 77	2	Substrate binding By similarity
Sites
	Active site	195	1	Schiff-base intermediate with substrate By similarity
	Site	167	1	Involved in proton transfer during cleavage By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5M8W9 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 02B53CFDBC0D3326	FASTA	328	35,644
	10 20 30 40 50 60 MFGRTLFPAR VIALGSGLFR TPLRTLAAGP ALSIGGIYPP IATPFTDKEE VDYGKLHENL 70 80 90 100 110 120 QNYSSFPFRG FVVQGSNGEY AYLTREERLE VVRRVRQAVP KEKLIMAGSG CESTQATIEM 130 140 150 160 170 180 TVEMAQSGAD AVLVVTPSYY RGKMTSSALV HHYTKVADHS PVPVVLYSVP ANTGLDLPVD 190 200 210 220 230 240 AVVTLSQHPN IIGLKDSGGD ITRIGLIIHK TKHLGFQVLS GSAGFLLAGY SVGAVGGVCA 250 260 270 280 290 300 LANVLGAQVC ELERLCLNGR WQEAKELQYR LIEPNTAVTR KFGIPGLKQA MEWFGFNGGK 310 320 CRSPLLPLTE QEIKELRHIF TVNGWLSL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CF375968 mRNA. No translation available. BC087798 mRNA. Translation: AAH87798.1.
RefSeq	NP_001263607.1. NM_001276678.1. XP_002939706.1. XM_002939660.1.
UniGene	Str.8565.
3D structure databases
HSSP	HSSP built from PDB template 1XL9 based on UniProtKB Q81WN7.
ProteinModelPortal	Q5M8W9.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000007453.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	496669.
KEGG	xtr:496669.
Organism-specific databases
CTD	112817.
Xenbase	XB-GENE-957775. hoga1.
Phylogenomic databases
eggNOG	COG0329.
HOVERGEN	HBG081405.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR002220. Dihydrodipicolinate_synth-like. IPR020625. Dihydrodipicolinate_synth_AS. [Graphical view]
PANTHER	PTHR12128. PTHR12128. 1 hit.
Pfam	PF00701. DHDPS. 1 hit. [Graphical view]
PIRSF	PIRSF001365. DHDPS. 1 hit.
PRINTS	PR00146. DHPICSNTHASE.
PROSITE	PS00665. DHDPS_1. False negative. PS00666. DHDPS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOGA1_XENTR

Accession

Primary (citable) accession number: Q5M8W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program