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Q5M8W9

- HOGA1_XENTR

UniProt

Q5M8W9 - HOGA1_XENTR

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Protein
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Gene
hoga1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the final step in the metabolic pathway of hydroxyproline By similarity.

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulationi

Inhibited by divalent cations By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei167 – 1671Involved in proton transfer during cleavage By similarity
Active sitei195 – 1951Schiff-base intermediate with substrate By similarity
Binding sitei197 – 1971Substrate By similarity
Binding sitei221 – 2211Substrate; via carbonyl oxygen By similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
    Alternative name(s):
    Dihydrodipicolinate synthase-like
    Short name:
    DHDPS-like protein
    Probable 2-keto-4-hydroxyglutarate aldolase
    Short name:
    Probable KHG-aldolase
    Gene namesi
    Name:hoga1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-957775. hoga1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626Mitochondrion Reviewed prediction
    Add
    BLAST
    Chaini27 – 3283024-hydroxy-2-oxoglutarate aldolase, mitochondrial
    PRO_0000273350Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer By similarity.

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000007453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5M8W9.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 772Substrate binding By similarity

    Sequence similaritiesi

    Belongs to the DapA family.

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0329.
    HOVERGENiHBG081405.
    KOiK18123.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.
    PROSITEiPS00666. DHDPS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5M8W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGRTLFPAR VIALGSGLFR TPLRTLAAGP ALSIGGIYPP IATPFTDKEE    50
    VDYGKLHENL QNYSSFPFRG FVVQGSNGEY AYLTREERLE VVRRVRQAVP 100
    KEKLIMAGSG CESTQATIEM TVEMAQSGAD AVLVVTPSYY RGKMTSSALV 150
    HHYTKVADHS PVPVVLYSVP ANTGLDLPVD AVVTLSQHPN IIGLKDSGGD 200
    ITRIGLIIHK TKHLGFQVLS GSAGFLLAGY SVGAVGGVCA LANVLGAQVC 250
    ELERLCLNGR WQEAKELQYR LIEPNTAVTR KFGIPGLKQA MEWFGFNGGK 300
    CRSPLLPLTE QEIKELRHIF TVNGWLSL 328
    Length:328
    Mass (Da):35,644
    Last modified:January 23, 2007 - v2
    Checksum:i02B53CFDBC0D3326
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CF375968 mRNA. No translation available.
    BC087798 mRNA. Translation: AAH87798.1.
    RefSeqiNP_001263607.1. NM_001276678.1.
    UniGeneiStr.8565.

    Genome annotation databases

    GeneIDi496669.
    KEGGixtr:496669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CF375968 mRNA. No translation available.
    BC087798 mRNA. Translation: AAH87798.1 .
    RefSeqi NP_001263607.1. NM_001276678.1.
    UniGenei Str.8565.

    3D structure databases

    ProteinModelPortali Q5M8W9.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000007453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 496669.
    KEGGi xtr:496669.

    Organism-specific databases

    CTDi 112817.
    Xenbasei XB-GENE-957775. hoga1.

    Phylogenomic databases

    eggNOGi COG0329.
    HOVERGENi HBG081405.
    KOi K18123.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    PROSITEi PS00666. DHDPS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiHOGA1_XENTR
    AccessioniPrimary (citable) accession number: Q5M8W9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: May 14, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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