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Protein

4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

hoga1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the final step in the metabolic pathway of hydroxyproline.By similarity

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulationi

Inhibited by divalent cations.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei167 – 1671Involved in proton transfer during cleavageBy similarity
Active sitei195 – 1951Schiff-base intermediate with substrateBy similarity
Binding sitei197 – 1971SubstrateBy similarity
Binding sitei221 – 2211Substrate; via carbonyl oxygenBy similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name:
DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name:
Probable KHG-aldolase
Gene namesi
Name:hoga1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unplaced

Organism-specific databases

XenbaseiXB-GENE-957775. hoga1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
BLAST
Chaini27 – 3283024-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000273350Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007453.

Structurei

3D structure databases

ProteinModelPortaliQ5M8W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 772Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DapA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0329.
HOVERGENiHBG081405.
InParanoidiQ5M8W9.
KOiK18123.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Schiff_base-form_aldolases_AS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
PROSITEiPS00666. DHDPS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M8W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGRTLFPAR VIALGSGLFR TPLRTLAAGP ALSIGGIYPP IATPFTDKEE
60 70 80 90 100
VDYGKLHENL QNYSSFPFRG FVVQGSNGEY AYLTREERLE VVRRVRQAVP
110 120 130 140 150
KEKLIMAGSG CESTQATIEM TVEMAQSGAD AVLVVTPSYY RGKMTSSALV
160 170 180 190 200
HHYTKVADHS PVPVVLYSVP ANTGLDLPVD AVVTLSQHPN IIGLKDSGGD
210 220 230 240 250
ITRIGLIIHK TKHLGFQVLS GSAGFLLAGY SVGAVGGVCA LANVLGAQVC
260 270 280 290 300
ELERLCLNGR WQEAKELQYR LIEPNTAVTR KFGIPGLKQA MEWFGFNGGK
310 320
CRSPLLPLTE QEIKELRHIF TVNGWLSL
Length:328
Mass (Da):35,644
Last modified:January 22, 2007 - v2
Checksum:i02B53CFDBC0D3326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CF375968 mRNA. No translation available.
BC087798 mRNA. Translation: AAH87798.1.
RefSeqiNP_001263607.1. NM_001276678.1.
UniGeneiStr.8565.

Genome annotation databases

GeneIDi496669.
KEGGixtr:496669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CF375968 mRNA. No translation available.
BC087798 mRNA. Translation: AAH87798.1.
RefSeqiNP_001263607.1. NM_001276678.1.
UniGeneiStr.8565.

3D structure databases

ProteinModelPortaliQ5M8W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi496669.
KEGGixtr:496669.

Organism-specific databases

CTDi112817.
XenbaseiXB-GENE-957775. hoga1.

Phylogenomic databases

eggNOGiCOG0329.
HOVERGENiHBG081405.
InParanoidiQ5M8W9.
KOiK18123.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Schiff_base-form_aldolases_AS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
PROSITEiPS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHOGA1_XENTR
AccessioniPrimary (citable) accession number: Q5M8W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2007
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.