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Protein
Submitted name:

Connective tissue growth factor

Gene

CTGF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Connective tissue growth factorImported
Submitted name:
cDNA FLJ77666, highly similar to Homo sapiens connective tissue growth factor (CTGF), mRNAImported
Gene namesi
Name:CTGFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27003

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501430986827 – 349Sequence analysisAdd BLAST323

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ5M8T4

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5M8T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 98IGFBP N-terminalInterPro annotationAdd BLAST74
Domaini101 – 167VWFCInterPro annotationAdd BLAST67
Domaini256 – 330CTCKInterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IH0W Eukaryota
ENOG4111F77 LUCA
HOVERGENiHBG000635
KOiK06827

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M8T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV
60 70 80 90 100
LDGCGCCRVC AKQLGELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG
110 120 130 140 150
APCIFGGTVY RSGESFQSSC KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF
160 170 180 190 200
PRRVKLPGKC CEEWVCDEPK DQTVVGPALA AYRLEDTFGP DPTMIRANCL
210 220 230 240 250
VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR PCEADLEENI
260 270 280 290 300
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
310 320 330 340
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA
Length:349
Mass (Da):38,069
Last modified:May 10, 2005 - v1
Checksum:i0ECF8470B357EA95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087839 mRNA Translation: AAH87839.1
DQ097843 Genomic DNA Translation: AAZ29611.1
HM015591 Genomic DNA Translation: ADL14512.1
AK290884 mRNA Translation: BAF83573.1
RefSeqiNP_001892.1, NM_001901.2
UniGeneiHs.410037

Genome annotation databases

GeneIDi1490
KEGGihsa:1490

Similar proteinsi

Entry informationi

Entry nameiQ5M8T4_HUMAN
AccessioniPrimary (citable) accession number: Q5M8T4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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