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Q5M8T2 (S35D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member D3
Alternative name(s):
Fringe connection-like protein 1
Gene names
Name:SLC35D3
Synonyms:FRCL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TPT transporter family. SLC35D subfamily.

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Solute carrier family 35 member D3
PRO_0000307727

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane64 – 8421Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane155 – 17521Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane280 – 30021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5M8T2 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 7995E3B253757C79

FASTA41644,183
        10         20         30         40         50         60 
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS TAALSLELLR 

        70         80         90        100        110        120 
RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS LPMYVVFKRC LPLVTMLIGV 

       130        140        150        160        170        180 
LVLKNGAPSP GVLAAVLITT CGAALAGAGD LTGDPIGYVT GVLAVLVHAA YLVLIQKASA 

       190        200        210        220        230        240 
DTEHGPLTAQ YVIAVSATPL LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN 

       250        260        270        280        290        300 
FTTLHCTYIN SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA 

       310        320        330        340        350        360 
KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE AAGGPAQESR 

       370        380        390        400        410 
QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR YMKKDYLIEN EELPSP 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Corpus callosum.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK295424 mRNA. Translation: BAG58370.1.
AL365223 Genomic DNA. Translation: CAI15712.2.
CH471051 Genomic DNA. Translation: EAW47939.1.
BC067217 mRNA. Translation: AAH67217.1.
BC087842 mRNA. Translation: AAH87842.1.
CCDSCCDS34544.1.
RefSeqNP_001008783.1. NM_001008783.1.
UniGeneHs.369703.

3D structure databases

ProteinModelPortalQ5M8T2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000333591.

Protein family/group databases

TCDB2.A.7.15.5. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ5M8T2.

Polymorphism databases

DMDM74736118.

Proteomic databases

PaxDbQ5M8T2.
PRIDEQ5M8T2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331858; ENSP00000333591; ENSG00000182747.
GeneID340146.
KEGGhsa:340146.
UCSCuc003qhe.3. human.

Organism-specific databases

CTD340146.
GeneCardsGC06P137243.
HGNCHGNC:15621. SLC35D3.
HPAHPA030431.
MIM612519. gene.
neXtProtNX_Q5M8T2.
PharmGKBPA134876893.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317482.
HOGENOMHOG000090215.
HOVERGENHBG106477.
InParanoidQ5M8T2.
KOK15281.
OMAAWTFPGW.
OrthoDBEOG7JMGDN.
PhylomeDBQ5M8T2.
TreeFamTF313307.

Gene expression databases

BgeeQ5M8T2.
CleanExHS_SLC35D3.
GenevestigatorQ5M8T2.

Family and domain databases

InterProIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi340146.
NextBio97707.
PROQ5M8T2.
SOURCESearch...

Entry information

Entry nameS35D3_HUMAN
AccessionPrimary (citable) accession number: Q5M8T2
Secondary accession number(s): B4DI58, Q5QNZ6, Q6NX71
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM