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Q5M8T2

- S35D3_HUMAN

UniProt

Q5M8T2 - S35D3_HUMAN

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Protein

Solute carrier family 35 member D3

Gene

SLC35D3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.By similarity

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.7.15.5. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member D3
Alternative name(s):
Fringe connection-like protein 1
Gene namesi
Name:SLC35D3
Synonyms:FRCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:15621. SLC35D3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876893.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Solute carrier family 35 member D3PRO_0000307727Add
BLAST

Proteomic databases

PaxDbiQ5M8T2.
PRIDEiQ5M8T2.

PTM databases

PhosphoSiteiQ5M8T2.

Expressioni

Gene expression databases

BgeeiQ5M8T2.
CleanExiHS_SLC35D3.
GenevestigatoriQ5M8T2.

Organism-specific databases

HPAiHPA030431.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333591.

Structurei

3D structure databases

ProteinModelPortaliQ5M8T2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317482.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000090215.
HOVERGENiHBG106477.
InParanoidiQ5M8T2.
KOiK15281.
OMAiAWTFPGW.
OrthoDBiEOG7JMGDN.
PhylomeDBiQ5M8T2.
TreeFamiTF313307.

Family and domain databases

InterProiIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5M8T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS
60 70 80 90 100
TAALSLELLR RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS
110 120 130 140 150
LPMYVVFKRC LPLVTMLIGV LVLKNGAPSP GVLAAVLITT CGAALAGAGD
160 170 180 190 200
LTGDPIGYVT GVLAVLVHAA YLVLIQKASA DTEHGPLTAQ YVIAVSATPL
210 220 230 240 250
LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN FTTLHCTYIN
260 270 280 290 300
SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA
310 320 330 340 350
KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE
360 370 380 390 400
AAGGPAQESR QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR
410
YMKKDYLIEN EELPSP
Length:416
Mass (Da):44,183
Last modified:February 1, 2005 - v1
Checksum:i7995E3B253757C79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295424 mRNA. Translation: BAG58370.1.
AL365223 Genomic DNA. Translation: CAI15712.2.
CH471051 Genomic DNA. Translation: EAW47939.1.
BC067217 mRNA. Translation: AAH67217.1.
BC087842 mRNA. Translation: AAH87842.1.
CCDSiCCDS34544.1.
RefSeqiNP_001008783.1. NM_001008783.1.
UniGeneiHs.369703.

Genome annotation databases

EnsembliENST00000331858; ENSP00000333591; ENSG00000182747.
GeneIDi340146.
KEGGihsa:340146.
UCSCiuc003qhe.3. human.

Polymorphism databases

DMDMi74736118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295424 mRNA. Translation: BAG58370.1 .
AL365223 Genomic DNA. Translation: CAI15712.2 .
CH471051 Genomic DNA. Translation: EAW47939.1 .
BC067217 mRNA. Translation: AAH67217.1 .
BC087842 mRNA. Translation: AAH87842.1 .
CCDSi CCDS34544.1.
RefSeqi NP_001008783.1. NM_001008783.1.
UniGenei Hs.369703.

3D structure databases

ProteinModelPortali Q5M8T2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000333591.

Protein family/group databases

TCDBi 2.A.7.15.5. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q5M8T2.

Polymorphism databases

DMDMi 74736118.

Proteomic databases

PaxDbi Q5M8T2.
PRIDEi Q5M8T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331858 ; ENSP00000333591 ; ENSG00000182747 .
GeneIDi 340146.
KEGGi hsa:340146.
UCSCi uc003qhe.3. human.

Organism-specific databases

CTDi 340146.
GeneCardsi GC06P137243.
HGNCi HGNC:15621. SLC35D3.
HPAi HPA030431.
MIMi 612519. gene.
neXtProti NX_Q5M8T2.
PharmGKBi PA134876893.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317482.
GeneTreei ENSGT00390000014204.
HOGENOMi HOG000090215.
HOVERGENi HBG106477.
InParanoidi Q5M8T2.
KOi K15281.
OMAi AWTFPGW.
OrthoDBi EOG7JMGDN.
PhylomeDBi Q5M8T2.
TreeFami TF313307.

Miscellaneous databases

GenomeRNAii 340146.
NextBioi 97707.
PROi Q5M8T2.
SOURCEi Search...

Gene expression databases

Bgeei Q5M8T2.
CleanExi HS_SLC35D3.
Genevestigatori Q5M8T2.

Family and domain databases

InterProi IPR004853. Tpt_PEP_trans_dom.
[Graphical view ]
Pfami PF03151. TPT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Corpus callosum.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.

Entry informationi

Entry nameiS35D3_HUMAN
AccessioniPrimary (citable) accession number: Q5M8T2
Secondary accession number(s): B4DI58, Q5QNZ6, Q6NX71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3