Q5M8T2 (S35D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member D3

Alternative name(s):
Fringe connection-like protein 1

Gene names

Name:	SLC35D3
Synonyms:	FRCL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TPT transporter family. SLC35D subfamily.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Solute carrier family 35 member D3		PRO_0000307727
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	257 – 277	21	Helical; Potential
	Transmembrane	280 – 300	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5M8T2 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 7995E3B253757C79	FASTA	416	44,183
	10 20 30 40 50 60 MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS TAALSLELLR 70 80 90 100 110 120 RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS LPMYVVFKRC LPLVTMLIGV 130 140 150 160 170 180 LVLKNGAPSP GVLAAVLITT CGAALAGAGD LTGDPIGYVT GVLAVLVHAA YLVLIQKASA 190 200 210 220 230 240 DTEHGPLTAQ YVIAVSATPL LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN 250 260 270 280 290 300 FTTLHCTYIN SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA 310 320 330 340 350 360 KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE AAGGPAQESR 370 380 390 400 410 QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR YMKKDYLIEN EELPSP

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Corpus callosum.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PNS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK295424 mRNA. Translation: BAG58370.1. AL365223 Genomic DNA. Translation: CAI15712.2. CH471051 Genomic DNA. Translation: EAW47939.1. BC067217 mRNA. Translation: AAH67217.1. BC087842 mRNA. Translation: AAH87842.1.
IPI	IPI00247490.
RefSeq	NP_001008783.1. NM_001008783.1.
UniGene	Hs.369703.
3D structure databases
ProteinModelPortal	Q5M8T2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000333591.
Protein family/group databases
TCDB	2.A.7.15.5. drug/metabolite transporter (DMT) superfamily.
PTM databases
PhosphoSite	Q5M8T2.
Polymorphism databases
DMDM	74736118.
Proteomic databases
PaxDb	Q5M8T2.
PRIDE	Q5M8T2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331858; ENSP00000333591; ENSG00000182747.
GeneID	340146.
KEGG	hsa:340146.
UCSC	uc003qhe.3. human.
Organism-specific databases
CTD	340146.
GeneCards	GC06P137243.
HGNC	HGNC:15621. SLC35D3.
HPA	HPA030431.
MIM	612519. gene.
neXtProt	NX_Q5M8T2.
PharmGKB	PA134876893.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317482.
HOGENOM	HOG000090215.
HOVERGEN	HBG106477.
InParanoid	Q5M8T2.
KO	K15281.
OMA	AWTFPGW.
OrthoDB	EOG4W6NW8.
PhylomeDB	Q5M8T2.
Gene expression databases
Bgee	Q5M8T2.
CleanEx	HS_SLC35D3.
Genevestigator	Q5M8T2.
Family and domain databases
InterPro	IPR004853. DUF250. [Graphical view]
Pfam	PF03151. TPT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	340146.
NextBio	97707.
SOURCE	Search...

Entry information

Entry name

S35D3_HUMAN

Accession

Primary (citable) accession number: Q5M8T2
Secondary accession number(s): B4DI58, Q5QNZ6, Q6NX71

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.