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Protein

Solute carrier family 35 member D3

Gene

SLC35D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32934-MONOMER.

Protein family/group databases

TCDBi2.A.7.15.5. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member D3
Alternative name(s):
Fringe connection-like protein 1
Gene namesi
Name:SLC35D3
Synonyms:FRCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:15621. SLC35D3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi340146.
OpenTargetsiENSG00000182747.
PharmGKBiPA134876893.

Polymorphism and mutation databases

BioMutaiSLC35D3.
DMDMi74736118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077271 – 416Solute carrier family 35 member D3Add BLAST416

Proteomic databases

PaxDbiQ5M8T2.
PeptideAtlasiQ5M8T2.
PRIDEiQ5M8T2.

PTM databases

iPTMnetiQ5M8T2.
PhosphoSitePlusiQ5M8T2.

Expressioni

Gene expression databases

BgeeiENSG00000182747.
CleanExiHS_SLC35D3.
GenevisibleiQ5M8T2. HS.

Organism-specific databases

HPAiHPA030431.

Interactioni

Protein-protein interaction databases

BioGridi131002. 3 interactors.
STRINGi9606.ENSP00000333591.

Structurei

3D structure databases

ProteinModelPortaliQ5M8T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000090215.
HOVERGENiHBG106477.
InParanoidiQ5M8T2.
KOiK15281.
OMAiWAFPGWK.
OrthoDBiEOG091G0AQT.
PhylomeDBiQ5M8T2.
TreeFamiTF313307.

Sequencei

Sequence statusi: Complete.

Q5M8T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS
60 70 80 90 100
TAALSLELLR RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS
110 120 130 140 150
LPMYVVFKRC LPLVTMLIGV LVLKNGAPSP GVLAAVLITT CGAALAGAGD
160 170 180 190 200
LTGDPIGYVT GVLAVLVHAA YLVLIQKASA DTEHGPLTAQ YVIAVSATPL
210 220 230 240 250
LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN FTTLHCTYIN
260 270 280 290 300
SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA
310 320 330 340 350
KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE
360 370 380 390 400
AAGGPAQESR QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR
410
YMKKDYLIEN EELPSP
Length:416
Mass (Da):44,183
Last modified:February 1, 2005 - v1
Checksum:i7995E3B253757C79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295424 mRNA. Translation: BAG58370.1.
AL365223 Genomic DNA. Translation: CAI15712.2.
CH471051 Genomic DNA. Translation: EAW47939.1.
BC067217 mRNA. Translation: AAH67217.1.
BC087842 mRNA. Translation: AAH87842.1.
CCDSiCCDS34544.1.
RefSeqiNP_001008783.1. NM_001008783.2.
UniGeneiHs.369703.

Genome annotation databases

EnsembliENST00000331858; ENSP00000333591; ENSG00000182747.
GeneIDi340146.
KEGGihsa:340146.
UCSCiuc003qhe.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295424 mRNA. Translation: BAG58370.1.
AL365223 Genomic DNA. Translation: CAI15712.2.
CH471051 Genomic DNA. Translation: EAW47939.1.
BC067217 mRNA. Translation: AAH67217.1.
BC087842 mRNA. Translation: AAH87842.1.
CCDSiCCDS34544.1.
RefSeqiNP_001008783.1. NM_001008783.2.
UniGeneiHs.369703.

3D structure databases

ProteinModelPortaliQ5M8T2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131002. 3 interactors.
STRINGi9606.ENSP00000333591.

Protein family/group databases

TCDBi2.A.7.15.5. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ5M8T2.
PhosphoSitePlusiQ5M8T2.

Polymorphism and mutation databases

BioMutaiSLC35D3.
DMDMi74736118.

Proteomic databases

PaxDbiQ5M8T2.
PeptideAtlasiQ5M8T2.
PRIDEiQ5M8T2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331858; ENSP00000333591; ENSG00000182747.
GeneIDi340146.
KEGGihsa:340146.
UCSCiuc003qhe.4. human.

Organism-specific databases

CTDi340146.
DisGeNETi340146.
GeneCardsiSLC35D3.
HGNCiHGNC:15621. SLC35D3.
HPAiHPA030431.
MIMi612519. gene.
neXtProtiNX_Q5M8T2.
OpenTargetsiENSG00000182747.
PharmGKBiPA134876893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000090215.
HOVERGENiHBG106477.
InParanoidiQ5M8T2.
KOiK15281.
OMAiWAFPGWK.
OrthoDBiEOG091G0AQT.
PhylomeDBiQ5M8T2.
TreeFamiTF313307.

Enzyme and pathway databases

BioCyciZFISH:G66-32934-MONOMER.

Miscellaneous databases

GenomeRNAii340146.
PROiQ5M8T2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182747.
CleanExiHS_SLC35D3.
GenevisibleiQ5M8T2. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiS35D3_HUMAN
AccessioniPrimary (citable) accession number: Q5M8T2
Secondary accession number(s): B4DI58, Q5QNZ6, Q6NX71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.